Examples of using Is a substrate in English and their translations into German
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Medicine
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Colloquial
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Official
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Ecclesiastic
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Financial
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Ecclesiastic
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Political
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Computer
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Programming
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Official/political
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Political
Lesinurad is a substrate of OATP1B1, OAT1, OAT3 and OCT1.
The complement component(protein) C4, is a substrate for activated C1s.
Isavuconazole is a substrate of CYP3A4 and CYP3A5 see section 5.2.
In vitro studies indicate that lenvatinib is a substrate for P-gp and BCRP.
Velpatasvir is a substrate of CYP2B6, CYP2C8, and CYP3A4 with slow turnover.
CYP3A4 or P-gp inhibitors: Ranolazine is a substrate of cytochrome CYP3A4.
Daclatasvir is a substrate of CYP3A4, P-gp and organic cation transporter(OCT) 1.
In vitro studies suggest that crizotinib is a substrate for P-glycoprotein P-gp.
Empagliflozin is a substrate of P-glycoprotein(P-gp) and breast cancer resistance protein BCRP.
The active metabolite of irinotecan, SN-38, is a substrate for OATP1B1 and UGT1A1.
Eltrombopag is a substrate for BCRP, but is not a substrate for P-glycoprotein or OATP1B1.
It is currently unknown whether vemurafenib is a substrate also to other transport proteins.
Tigecycline is a substrate of P-gp based on an in vitro study using a cell line overexpressing P-gp.
Additionally, in vitro studies have shown that saquinavir is a substrate and an inhibitor for P-glycoprotein P-gp.
Teriflunomide is a substrate of the efflux transporter BCRP, which could be involved in direct secretion.
In vitro studies demonstrated that neither oseltamivir nor the active metabolite is a substrate for, or an inhibitor of, the major cytochrome P450 isoforms.
It is a substrate and an inhibitor of the hepatic uptake transporter OATP1B1; and a substrate for the hepatic efflux transporter MRP2.
In vitro studies indicated that trifluridine is a substrate for the nucleoside transporters CNT1, ENT1 and ENT2.
Milbemycin oxime is a substrate for P-glycoprotein(P-gp) and therefore could interact with other P-gp substrates(for example, digoxin, doxorubicin) or other macrocyclic lactones.
In vitro transport studies showed that sitagliptin is a substrate for p-glycoprotein and organic anion transporter-3 OAT3.
Dabrafenib is a substrate for the metabolising enzymes CYP2C8 and CYP3A4, while the active metabolites hydroxy-dabrafenib and desmethyl-dabrafenib are CYP3A4 substrates. .
In vitro studies indicate that tolvaptan is a substrate and competitive inhibitor of P-glycoprotein P-gp.
Z-DEVD-R110, which is a substrate of caspase 3/7, for up to 18 hours.
In vitro and in vivo studies demonstrate that daclatasvir is a substrate of CYP3A, with CYP3A4 being the major CYP isoform responsible for the metabolism.
In vitro: Cysteamine bitartrate is a substrate of P-gp and OCT2, but not a substrate of BCRP, OATP1B1, OATP1B3, OAT1, OAT3 and OCT1.
In vitro studies indicate that lapatinib is a substrate for the transporters BCRP(ABCG1) and p-glycoprotein ABCB1.
Aprepitant(125 mg/ 80 mg) is a substrate, a moderate inhibitor, and an inducer of CYP3A4.
In vitro data indicate that paritaprevir is a substrate for the human hepatic uptake transporters, OATP1B1 and OATP1B3.
In vitro experiments show that simeprevir is a substrate for the drug transporters P-glycoprotein(P-gp), MRP2, OATP1B1/3 and OATP2B1.
On the other hand, the universal substrate CIEMHUS It is a substrate balanced and ready for use in all types of indoor plants, Foreign and horticultural.