Examples of using Comt in English and their translations into Hungarian
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Metabolism(by extraneuronal MAO and COMT).
Entacapone inhibits the COMT enzyme mainly in peripheral tissues.
Medicinal products metabolised by COMT.
Tasmar blocks COMT and slows the breakdown of levodopa.
The researchers also focused on a variant of a gene called COMT.
Tasmar, as a COMT inhibitor, is known to increase the bioavailability of the co-adminstered levodopa.
No effects were seen on the pharmacokinetics of the COMT substrate carbidopa.
Tasmar, as a COMT inhibitor, is known to increase the bioavailability of the co-adminstered levodopa.
Rhodiola also works toblock the breakdown of serotonin by inhibiting the enzyme COMT.
With 200 mg tolcapone, maximum inhibition of erythrocyte COMT activity is, on average, greater than 80%.
In Irkutsk, for example, a small town, but the key for Eastern Siberia, was the so-called Comt Lodge.
Transient elevation above pretreatment levels of erythrocyte COMT activity was observed after withdrawal of tolcapone.
Entacapone belongs to a new therapeutic class, catechol-O-methyl transferase(COMT) inhibitors.
Comtess 200 mg film-coated tablets are brownish-orange,oval tablets with"COMT" engraved on one side.
Entacapone decreases the metabolic loss of levodopa to 3- O-methyldopa(3-OMD) by inhibiting the COMT enzyme.
Entacapone is a reversible, specific and mainly peripherally acting COMT inhibitor designed for concomitant administration with levodopa.
The consequent increase in dopaminergic stimulationcan lead to the dopaminergic side effects observed after treatment with COMT inhibitors.
It is a reversible, specific, and mainly peripherally acting COMT inhibitor designed for concomitant administration with levodopa preparations.
The consequent increase indopaminergic stimulation can lead to the dopaminergic side effects observed after treatment with COMT inhibitors.
The effect of tolcapone on the pharmacokinetics of other drugs metabolised by COMT such as α-methyldopa, dobutamine, apomorphine, adrenaline and isoprenaline have not been evaluated.
COMT inhibition in red blood cells closely follows the plasma concentrations of entacapone, thus clearly indicating the reversible nature of COMT inhibition.
There are many other genes that affect THCsensitivity,including CNR1 which encodes the CB1 receptor and COMT, which encodes another metabolic protein.
In the presence of a DOPA decarboxylase inhibitor(DDCI), COMT becomes the major metabolising enzyme for levodopa, catalysing its conversion to 3-O-methyldopa(3-OMD) in the brain and periphery.
Tasmar is indicated in combination with levodopa/ benserazide or levodopa/ carbidopa for use in patients with levodopa-responsive idiopathic Parkinson' s disease and motor fluctuations,who failed to respond to or are intolerant of other COMT inhibitors(see 5.1).
Opicapone may interfere with the metabolism of medicinal productscontaining a catechol group that are metabolised by COMT, e.g. rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dopexamine or dobutamine, leading to potentiated effects of these medicinal products.
Because of the risk of rare but potentially fatal acute liver injury, Tasmar is only indicated for use in patients with levodopa-responsive idiopathic Parkinson's disease and motor fluctuations,who failed to respond to or are intolerant of other COMT inhibitors.
However, the experience of the clinical use of entacapone with several medicinal products, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine,and medicinal products that are metabolised by COMT( e. g. catechol- structured compounds: rimiterol, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa, apomorphine, and paroxetine) is still limited.
A significant number of Parkinson's disease patients have been treated with the combination of levodopa, carbidopa and entacapone with several active substances including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine,maprotiline and venlafaxine and medicinal products that are metabolised by COMT(e.g. catechol-structured compounds, paroxetine).
In research8 published in 2012, Ted Kaptchuk and Kathryn Hall at the Beth Israel Deaconess Medical Center in Bostonfound that different versions of a gene called COMT could predict placebo response in people with irritable bowel syndrome(IBS).