Examples of using Integrase in English and their translations into Hungarian
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Integrase Inhibitors.
And 24% were on integrase inhibitors.
Integrase Inhibitors.
The newly formed viral DNA is then integrated with human host cellDNA using a viral enzyme called integrase.
Integrase is an HIV-1 encoded enzyme that is required for viral replication.
People also translate
In subtype C(n=2) and A/G(n=2) isolates the integrase substitution R263K was selected in one isolate, and G118R in two isolates.
Vitekta has been investigated in one main study involving 712 patients withHIV-1 who had not been treated before with an integrase inhibitor.
All three had taken integrase inhibitors and integrase and had several resistance mutations.
At the beginning of the study, half were taking NNRTI-based schemes,one-third were taking integrase inhibitors and 17% were in protease inhibitors.
It blocks an enzyme called integrase that is needed for the subsequent stage of virus replication.
Predictors of efficacy included drug choice,with results favoring both tenofovir/ entricibin and integrase inhibitors.
(MedPage Today)- The integrase inhibitor raltegravir(Isentress) can be used to treat HIV in children and adolescents ages two through 18, the FDA announced.
In this study,Vitekta was at least as effective as raltegravir(another integrase inhibitor) when taken in combination with other anti-HIV medicines.
Predictors of efficacy included choice of drug,with outcomes favouring both tenofovir/emtricibine and integrase inhibitors.
This is an antiviral medicine that blocks an enzyme called integrase that is needed by the HIV virus to make new copies of itself in the body.
The second study involved 833 patients given either a combination of Tivicay with two NRTIs or a different three-drug combination(Atripla)that did not include an integrase inhibitor.
By blocking an enzyme called integrase, elvitegravir stops the virus's genetic material from integrating into the genetic material of the cells it has infected.
Therefore, Tivicay is recommended to betaken with food by patients infected with HIV with integrase class resistance(see section 4.2).
An update in 2012 showed that treatment based on an integrase inhibitor was superior to treatment including either a boosted protease inhibitor or NNRTI.
The major classes of anti-HIV drugs are nucleoside reverse transcriptase inhibitors(NRTIs), non-nucleoside reverse transcriptase inhibitors(NNRTIs),increased protease inhibitors, and integrase inhibitors.
It also showed that differences in results according to viral load were lower for the integrase inhibitors than the potentiated protease inhibitors and NNRTIs.
HIV transmission with integrase inhibitor resistance é very rare, and in particular resistance to all drugs except raltegravir, the first integrase inhibitor.
Most had a signature mutation at amino acid 155(N155 changed to H), amino acid 148(Q148 changed to H, K, or R), or amino acid 143(Y143 changed to H, C, or R),along with one or more additional integrase mutations.
Cross-resistance between nevirapine and either HIV protease inhibitors, HIV integrase inhibitors or HIV entry inhibitors is unlikely because the enzyme targets involved are different.
Other substitutions in integrase that occurred in addition to a primary INSTI resistance substitution each in single cases were H51Y, L68V, G140C, S153A, E157Q, and G163R.
Whereas dolutegravir monotherapy was not inferior to the ART combination at week 24,virological failure continued to occur after week 24 and led to the integrase resistance of associated mutations in 3 patients," the researchers concluded.
In the Platform ACE system(Figure 1A), an ACE Integrase expression vector is co-transfected with an ACE-targeting vector(ATV) into a cell line harboring the Platform ACE(Figure 1B).
Since four of the five first-line regimens are recommended by the Department of Health and Human Services, are based on integrase inhibitors, and that this class of drugs is being evaluated for use as PrEP, it would be the concern that more resistant viruses to resistant integrase inhibitors began to circulate.
De novo resistance was not detected to the integrase class or the NRTI class in any patients who were treated with dolutegravir+ abacavir/lamivudine in the three studies mentioned.
Tivicay®- Dolutegravir® is a potent and well tolerated integrase inhibitor with a high genetic barrier to resistance, making it a good candidate for simplified therapy.
