Examples of using Protein function in English and their translations into Japanese
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AS affecting protein function total 24249.
Network-based prediction of protein function.
Protein function is strongly related to its structure.
Table 3. AS affecting protein function and Complex AS pattern.
These conserved amino acids are likely important for protein function.
Study protein function, structure-function relationships, or nucleic acid-protein interactions.
Similarly, methods for determining protein function are well known.
Protein function depends not only on local interactions between amino acids but also on communication between separated sites.
Scientists have alwayslooked to mutant organisms to provide clues about protein function.
Unfortunately, the databases of protein function that are used to make annotations are far from complete.
The appropriate exon(s) for complete disruption of the anticipated protein function is selected.
Because silent mutations do not alter protein function they are often treated as though they are evolutionarily neutral.
We hope that these improvementsenhance the utility of the AID technology for studying protein function in living human cells.
Variants that have strong effects on protein function or diseases can offer insights into the role of particular genes in disease risk.
The study highlights focusing on families of interactiondomains as a productive approach to gain insight into protein function.
For example,molecular biologist Douglas Axe has shown that protein function is lost when DNA sequences are changed at random.
In contrast, the amino acid positions where substitutions have been tolerated by natural selectionindicates that these positions are not critical for protein function.
The accelerated growth of protein databases offers great possibilities for the study of protein function using sequence similarity and conservation.
Synthetic biologists are testing nucleotide andamino acid-level variations in target genes to gain understanding of protein function in oncogenesis.
The impact of ubiquitination on protein function(6), expression, or localization depends on whether a single ubiquitin moiety(monoubiquitination) or a chain(polyubiquitination) has been attached to a protein(Figure 3).
This gold standard was independently conceived by Valle's research group, andcontains 923 human disease genes organized in 14 categories of protein function.
Nevertheless, the Swiss-Prot curators curateonly 35% to 45% of new articles about protein function, and they focus on a few well-studied model organisms(5).
TOPICS(1) Protein structure prediction, de novo design, protein folding A protein sequence folds into a unique three-dimensional structure andthis structure in turn expresses a unique protein function.
Raif Geha and colleagues looked at the molecular basis for DOCK8 protein function in antibody-producing B immune cells. They found that signaling cascades involving the adaptor protein DOCK8 are required for normal antibody production and generation of B cell memory responses.
Molecular geneticists are understandably interested in DNA changes as molecular events,and any that have no effect on protein function may reasonably be called neutral mutations.
In chemical genetics,the technology for high-throughput screening of a bioprobe regulating a protein function is very important. The identification of small-molecule bioprobes for a protein of interest can facilitate not only the functional analysis of the protein but also the development of clinical drugs.
The researchers created and developed the proteins with a specific function andtheir method reveals a possibility that certain protein functions can be created on demand.
Photochemical techniques and findings are applied to biological imaging by a team of researchers from different fields To observe cell membrane structures,organelle distribution, and protein functions in living cells, equipment-based techniques and observation methods should be improved, and novel labeling substances with high sensitivity and high spatial and temporal resolution should be developed.
Cysteine, which is one of the amino acids in protein, is particularly susceptible to the redox environment, and because it is also the key residue for intramolecular covalent bonds, which are important in the determination of protein structure, knowledge of its statehas become important information in the clarification of protein function and its regulation.