Examples of using Phase reactants in English and their translations into Portuguese
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Medical therapy, cytokines,metalloproteinases and acute phase reactants.
We emphasize that an abdominal and groin pain with elevated acute phase reactants should prompt an evaluation for retroperitoneal fibrosis.
Acute phase reactants used to evaluate systemic inflammation included the Westergren erythrocyte sedimentation rate ESR and C-reactive protein CRP.
White blood cell count can be elevated in 50-60% of cases;acute phase reactants are usually high and muscle enzymes are often normal, as observed in this case.
Table 1 describes demographic features, time since the onset of symptoms attributable to TA,time since diagnosis and acute phase reactants in subgroups of TA patients.
Consistent with the effect on acute phase reactants, treatment with tocilizumab was associated with reduction in platelet count within the normal range.
Significant improvements are seen in the pain, tender joint count,physical function(HAQ score), acute phase reactants and in the patient's and physician's global assessment.
Periodic complete blood count(CBC)and acute phase reactants should be carried out to determine if red blood cell transfusion is necessary and to evaluate the control of inflammation.
Several parameters have been proposed such as serum levels of some autoantibodies,Complement components determination, acute phase reactants, evaluation of urinary sediment and hematimetric index, and others.
Patients with possible active disease i.e. only high acute phase reactants without signs and symptoms of active TA present higher serum IL-6 and IL-18 levels than patients with inactive disease.
Vigilance for the timely detection of serious infection is recommended for patients receiving biological treatments for moderate to severe RA as signs and symptoms of acute inflammation may be lessened,associated with suppression of the acute phase reactants.
Although some studies have shown increased levels of plasma pro-inflammatory cytokines and acute phase reactants in patients with depression, contradictory results also have been described.
TA patients presenting abnormal levels of acute phase reactants i.e. ESR>= 40 mm/h and/or serum CRP levels>= 10 mg/dL without signs and symptoms of active TA or new angiographic lesions were considered a distinct subgroup named as possible active disease.
Treatment with canakinumab resulted in a rapid and sustained improvement of both the articular and the systemic features of SJIA with significant reduction of the number of inflamed joints,prompt resolution of fever and reduction of acute phase reactants in the majority of patients see Clinical efficacy and safety.
Over evolution, the patient presented fever peaks of 41?? C and elevated acute phase reactants, getting three positive blood cultures for methicillin-sensitive staphylococcus aureus, starting antibiotic therapy with parenteral oxacillin.
Disease activity was defined whether the onset or worsening of at least two of the following features was present: a systemic features with no other identified cause; b the onset of features of vascular ischemia or inflammation, such as limb claudication, unequal or absent pulse, bruit, vascular pain carotidynia or asymmetric blood pressure;c elevated acute phase reactants including erythrocyte sedimentation rate ESR; d development of new lesions in previously unaffected vascular territories on serial vascular imaging evaluation.
Increased expression andproduction of cytokines and acute phase reactants such as C-reactive protein CRP, interleukins ILs, tumor necrosis factor? TNF-?, or lipopolysaccharides LPS result in the low degree of inflammation among obese individuals.
Tests used for the diagnosis of LOS: blood culture peripheral and/or central method used for its implementation, interpretation of results taking into account time and growth curve, use of blood count,acute phase reactants, hematological scores, CSF collection indications and repeat lumbar puncture, and interpretation of growth of coagulase-negative staphylococci in blood culture contamination or infection.
The normalization of blood count parameters and acute phase reactants, shown inTable 2, also indicated statistical difference between the initial and resolution parameters for the absolute count of leukocytes p< 0.0001, neutrophils p< 0.0004, lymphocytes p< 0.0001, and platelets p< 0.005, but there was no significant difference between baseline and resolution parameters for hemoglobin, C-reactive protein, and ESR.
Moreover, the weakness of the NIH criteria is highlighted by the fact that TA patients with high acute phase reactants who do not fulfill the NIH criteria for active disease actually present higher serum levels of IL-6 and IL-18 than TA patients considered with inactive disease.
Seen by a colleague who requested further laboratory tests, elevated acute phase reactants was found and now with high titers of antinuclear antibodies 1/640 and anti-DNA antibodies at very high titers by enzyme-immunoassay 190 U normal values below 40 U.
These phenomena are indicated by several hemorheological parameters,including the acute phase reactants erythrocyte sedimentation rate ESR and fibrinogen, which are therefore predictors and biomarkers of major adverse cardiovascular events MACE, acute coronary syndrome, coronary heart disease CHD, and ischemic stroke.
The evaluation of this and other cytokines, such as TGF-?, IFN-?, and IL-10,has not been very informative.A study that identified which acute phase reactants and cytokines would be useful for monitoring therapy with infliximab in AS analyzed 22 cytokines and showed that serum IL-1? distinguished patients responsive to treatment at week 6 with a sensitivity of 84.9% and specificity of 53.8.
There was a good correlation between SAA and ESR, CRP, and BASDAI, and therefore, the authors proposed it as a candidate for activity biomarker. Thus,SAA is among the acute phase reactants that best predict treatment response in SpA, along with CRP and IL-6.A combination of elevated basal levels of CRP and SAA show a greater predictive value for clinical response 81% in patients with AS treated with anti-TNF.
Recently, an additional acute phase reactant, SAA, has been shown to be elevated in SpA and correlated with CRP, ESR, and BASDAI.
The diagnosis of TA is based on the EULAR/PRINTO/PRES criteria, that comprises: angiographic abnormalities, alterations in peripheral arterial pulses, systolic blood pressure BP discrepancy in any limb, arterial hypertension,large artery bruits, and elevated acute phase reactant.
Fibrinogen is a part of homeostasis events, being an acute phase reactant that responds to stress.
Although serum ferritin is a sensitive test for iron load,as an acute phase reactant, it is not a specific test.
MBL is an acute phase reactant that binds to mannose, sugars, and other microbial compounds by way of the lectin domain.
This is due to the ESR being largely dependent on elevation of fibrinogen, an acute phase reactant with a half-life of approximately one week.