Examples of using Polymorphic forms in English and their translations into Portuguese
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A number of methods can be used to characterize the polymorphic forms of an API.
Crystalline solids and polymorphic forms can be characterized, detected and identified.
For this, we built a ternary mixture design with 21 samples of polymorphic forms of mbz.
All polymorphic forms of mbz have been reported in pharmaceutical raw materials and commercial formulae.
Raman, and solid-state nuclear magnetic resonance(ssNMR)are helpful for further characterization of polymorphic forms.
However, the influence of polymorphic forms of these genes has shown conflicting results in different populations.
Knowing that these ingredients can exhibit the phenomenon of polymorphism,this technique is efficient to differentiate among polymorphic forms.
On the other hand, the different MTHFR A1298 C polymorphic forms were not associated with RA, or serum levels of TNF-?, OPN or BAFF.
Polymorphic forms of methylene tetrahydrofolate reductase MTHFR gene and some cytokine genes have been studied as possible markers of susceptibility, severity, and/or protection in RA.
On studying the association between rheumatoid arthritis and different polymorphic forms of MTHFR C677 T, MTHFR A1298 C, TGF-? 1 T869 C and LT-? A252G Table 3.
It can be obtained from different polymorphic forms of chitin, of which the form¿has proven advantageous because it promotes more homogeneous and chemical modifications leads to a final product less allergenic.
Moreover, no significant association has been detected between different polymorphic forms of TGF-? 1 T869 C polymorphism and rheumatoid arthritis Table 3.
Polymorphic forms of the same chemical compound differ in internal solid-state structure and, therefore, may possess different chemical and physical properties, including packing, thermodynamic, spectroscopic, kinetic, interfacial and mechanical properties.
We found that serum TNF-?level differs significantly in the different polymorphic forms of all tested genes except MTHFR A1298 C as shown in Table 4.
The investigation of polymorphism associated with oxycans, a group belonging to the class of non-steroidal anti-inflammatory drugs(nsaids), has grown in recent years, andit is reported that there are four polymorphic forms for tenoxycam the literature.
The literature references orstudies performed to identify the potential polymorphic forms of the API, including the study results, should be provided in section 3.2.
The concentration distribution maps of the polymorphic forms i and iii of carbamazepine in the tablet were estimated by partial least squares(pls), multivariate curve resolution(mcr) and parallel factor analysis(parafac), as well as the concentration profile as a function of the heating time and the results were compared regarding the efficacy in quantification of the polymorphic forms.
Rubini et al. reported association of CC genotype of MTHFR A1298 C butnot any of MTHFR C677 T polymorphic forms with susceptibility to RA in Italian population.
Thus, the aim of this work is to quantify the polymorphic forms of mebendazole in raw material using mid infrared(mir), near infrared(nir) and terahertz(thz) spectroscopies.
Among these additives there are emulsifiers, which unlike its usual application can be used to alter the crystal structure andalso contribute to the stability of desired polymorphic forms in the oil and fat where they are applied.
The identification and control of polymorphic forms can be performed using various techniques, among which thermal analysis, infrared spectroscopy, raman spectroscopy and x-ray powder diffraction.
The present work included the characterization of venlafaxine hydrochloride, development and validation of a method to quantify the drug in extended-release capsules by high performance liquid chromatography(hplc), as well as the study of different crystalline forms of venlafaxine hydrochloride, evaluation of the presence of different polymorphs in raw materials and development andvalidation of a quantification method for polymorphic forms 1 and 2 by x-ray diffraction using the rietveld refinement.
Interpret how changes to chemical reactions,concentrations, polymorphic forms, and heat flow affect the particle distribution through seamless communication with iC PVM, iC IR, iC Raman, iControl RC1e, iControl LabMax, and iControl software.
Results of previous studies were heterogeneous; some showed no association between risk of RA and different polymorphic forms of MTHFR C677 T and A1298 C. Others reported association of T allele, but not any of the MTHFR C677 T polymorphic forms with RA.
When the difference of solubility is considerable between polymorphic forms, the bioavailability of the drug can be affected i.e., it can affect the rate in which the active ingredient becomes available at the site of action, and thus change the efficacy of a pharmaceutical compound.
Decision tree 4 of ICH Q6A can be used where screening is necessary and 4(2)can be used to investigate if different polymorphic forms have different properties that may affect performance, bioavailability and stability of the FPP and to decide whether a preferred polymorph should be monitored at release and on storage of the API.
If a polymorphic form is to be defined or limited e.g.
The polymorphic form was present in the samples i and the mixture of nimesulide with¿-cyclodextrin increased the solubility of the drug by more than 10 times.
The unexpected appearance or disappearance of a polymorphic form may lead to serious pharmaceutical consequences.
The polymorphic form(s) present in the proposed API should be listed in section 3.2.