Examples of using Modafinil in English and their translations into Russian
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Colloquial
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Official
You hear of modafinil?
Modafinil is becoming increasingly popular among the general population.
This nootropic is similar to adrafinil and modafinil.
Therefore, I am taking modafinil, it was necessary to cope with fatigue.
Fladrafinil is a stronger alternative to adrafinil and modafinil.
Modafinil was screened at a large panel of receptors and transporters in an attempt to elucidate its pharmacology.
The French government indicated that the Foreign Legion used modafinil during certain covert operations.
Modafinil is actually a mixture of two enantiomers, where only the R isomer shows the indicated biological activity.
In vitro measurements indicate that 60% of modafinil is bound to plasma proteins at clinical concentrations of the drug.
Modafinil may be an effective and well-tolerated treatment in patients with seasonal affective disorder/winter depression.
CRL-40, 941 is a white crystalline solid substance that has been described as closely related to both adrafinil and modafinil.
In the United States military, modafinil has been approved for use on certain Air Force missions, and it is being investigated for other uses.
On October 6, 1994, Cephalon filed an additional patent,covering modafinil in the form of particles of defined size.
Modafinil induces the cytochrome P450 enzymes CYP1A2, CYP3A4, and CYP2B6, as well as inhibiting CYP2C9 and CYP2C19 in vitro.
There was weak evidence forthe efficacy of amantadine, pemoline, and modafinil in reducing fatigue in patients with multiple sclerosis.
Modafinil has a considerably smaller list of side effects than caffeine but due to its unknown long-term effects it remains a prescription drug.
The Canadian Medical Association Journal also reports that modafinil is used by astronauts on long-term missions aboard the International Space Station.
Taking adrafinil early in the morning is unlikely to disrupt sleep since about 50% of the active agent(modafinil) will be cleared after 15 hours.
Modafinil is"available to crew to optimize performance while fatigued" and helps with the disruptions in circadian rhythms and with the reduced quality of sleep astronauts experience.
As of 2004,the FDA is not aware of any fatal overdoses involving modafinil alone as opposed to multiple drugs including modafinil.
Modafinil can cause uncomfortable side effects, including nausea, headache, and a dry mouth for some patients, while other patients report no noticeable improvement even on relatively high dosages.
It is a weak dopamine reuptake inhibitor with an IC50 of 9 μM,notably 59% weaker than modafinil(IC50 3.70 μM) despite being a stronger eugeroic, potentially making it even less liable for addiction.
Modafinil- work without sleep? 10 p Modafinil was originally created to treat narcolepsy(a condition when a person falls asleep at inappropriate times), but it spread widely among students and businessmen.
I have over 100 publications and 4 text book chapters in Investigative Neuroimaging in a variety of disorders including Drug Addiction and Obesity, and in the mechanisms of actions of several medications,for example Modafinil.
People that take modafinil and armodafinil probably have a small reduction in sleepiness and an increase in alertness during the night shift, based on evidence at three months' follow-up in people with shift work sleep disorder(moderate quality evidence).
A study published by chemists working for the biopharmaceutical company Cephalon to develop a successor to the eugeroic modafinil reported that the corresponding fluorenol derivative was 39% more effective than modafinil at keeping mice awake over a 4-hour period.
Modafinil and/or its major metabolite,modafinil acid, may be quantified in plasma, serum or urine to monitor dosage in those receiving the drug therapeutically, to confirm a diagnosis of poisoning in hospitalized patients or to assist in the forensic investigation of a vehicular traffic violation.
From the date of initial marketing, December 1998, to January 30, 2007, the US Food andDrug Administration received six cases of severe cutaneous adverse reactions associated with modafinil, including erythema multiforme(EM), Stevens-Johnson syndrome(SJS), toxic epidermal necrolysis(TEN), and DRESS syndrome, involving adult and pediatric patients.
Pertinent questions include whether modafinil may be modified or manufactured to avoid the granularities specified in the new Cephalon patent, and whether patenting particle size is invalid because particles of appropriate sizes are likely to be obvious to practitioners skilled in the art.