Examples of using Repressor in English and their translations into Russian
{-}
-
Colloquial
-
Official
The lacI gene synthesizes LacI repressor protein.
Then a repressor protein, that blocks the operating cells?
The unlinked galR gene encodes the repressor for this system.
An example of a repressor protein is the methionine repressor MetJ.
Repression of gene expression works via binding of repressor molecules to the two operators.
RAP1(Repressor/ Activator Protein 1): RAP1 is a stabilizing protein associated with TRF2.
In the presence of the inducer allolactose, the repressor changes conformation and falls off the operator.
A repressor that binds with a corepressor is termed an aporepressor or inactive repressor.
The binding of the inducer to the repressor prevents the repressor from binding to the operator.
A repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers.
One of the genes regulated by trp repressor, trpR,codes for the tryptophan repressor protein itself.
If an inducer, a molecule that initiates the gene expression, is present,then it can interact with the repressor protein and detach it from the operator.
Competition between the activator and repressor ensures that both mRNA types(with and without exon 2) are produced.
In one study, a total absence of TrkA receptor was found in keratoconus-affected corneas,along with an increased level of repressor isoform of Sp3 transcription factor.
The(tryptophan) repressor is a 25 kD protein homodimer which regulates transcription of the tryptophan biosynthetic pathway in bacteria.
In this way activator proteins become active to bind to the DNA to promote RNA Polymerase and repressor proteins become inactive and RNA polymerase can bind to the DNA.
Tryptophan repressor(or trp repressor) is a transcription factor involved in controlling amino acid metabolism.
This causes chromosome looping, allowing the promoter region and the silencer region to come to close proximity. lacZYA transcribes the proteins needed for lactose breakdown.lacI synthesizes the repressor of the lacZYA gene.
When SAM concentration becomes low, the repressor dissociates from the operator site, allowing more methionine to be produced.
A repressor is a DNA-binding protein that regulates the expression of one or more genes by binding to the operator and blocking the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes.
Initially described as a transcription factor able to activate expression of the cytokine Interferon beta,IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes.
In most cases,such as in the Cro repressor, the second helix contributes most to DNA recognition, and hence it is often called the"recognition helix.
The discovery of the helix-turn-helix motif was based on similarities between several genes encoding transcription regulatory proteins from bacteriophage lambda and Escherichia coli: Cro, CAP,and λ repressor, which were found to share a common 20-25 amino acid sequence that facilitates DNA recognition.
This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor.
BHC80 is a component of a BRAF35(MIM 605535)/histone deacetylase(HDAC; see MIM 601241) complex(BHC)that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1(RE1) or neural restrictive silencer(NRS) Hakimi et al., 2002.
For example, the E. coli tryptophan repressor(TrpR) is only able to bind to DNA and repress transcription of the trp operon when its corepressor tryptophan is bound to it.
This may be due to the disorder of let-7 regulation of its target Nr6a1(also known as Germcell nuclear factor- GCNF), an embryonic transcriptional repressor of pluripotency genes that regulates gene expression in adult fibroblasts following micro-RNA miRNA loss.
If there isn't enough tryptophan, the repressor protein breaks off from the operator(where the repressor is normally bound) and RNA polymerase can complete its reading of the strand of DNA.
It also has shown to interact with the NO-saystem,providing endothelium protection and angiogenic effect, even in severely impaired conditions(i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and factor generation and early extracellular matrix(collagen) formation(but also its repressor nerve factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD.
The E. coli lactose operon repressor LacI(PDB: 1lcc chain A) and E. coli catabolite gene activator(PDB: 3gap chain A) both have a helix-turn-helix motif, but their amino acid sequences do not show much similarity.