Examples of using Conformational in English and their translations into Serbian
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Binding of calcium causes a conformational change to occur in the protein.
Vezivanje kalcijuma uzrokuje konformacionu promenu proteina.Rotation and tilting of transmembrane α-helices may both contribute to these conformational changes.
Rotacija i naginjanje transmembranskih α-heliksa mogu da doprinesu tim konformacionim promenama.Conformational deviations are primarily located in the four loops reaching in the ligand binding site.
Konformacione devijacije su prvenstveno locirane na četiri petlje u blizini mesta gde se ligand vezuje.The sixth residue in the loop is necessarily glycine due to the conformational requirements of the backbone.
Deveti ostatak u petlji je nužno glicin, zbog konformacionih zahteva proteinske osnove.This conformational change results in the increased affinity of the second α subunit for a second ACh ligand.
Ova konformaciona promena dovodi do povećanja afiniteta druge α podjedinice za drugi ACh ligand.The equilibrium can favor either direction depending on ring size and other conformational effects.
Položaj ravnoteže može da bude na jednoj ili drugoj stani, u zavisnosti od veličine prstena i drugih konformacionih efekata.The model that describes the conformational changes associated with the binding of the substrate is the alternating-access model.
Mehanizam koji opisuje konformacione promene usled vezivanja supstrata je model naizmeničnog pristupa.The structures of BtuCD and the BtuCD homolog, HI1470/1,represent two different conformational states of an ABC transporter.
Strukture BtuCD i BtuCD homologa, HI1470/ 1,predstavljaju dva različita konformaciona stanja ABC transportera.Pyrimidine dimers introduce local conformational changes in the DNA structure, which allow recognition of the lesion by repair enzymes.
Pirimidinski dimeri unose lokalne konformacione promene u DNK strukturu, što omogućava enzimima za popravku da prepoznaju oštećenja.During the detection of diatomic gases,the binding of the gas ligand to the heme iron induces conformational changes in the surrounding protein.
Tokom detekcije diatomskih gasova,vezivanje gasovitog liganda za gvožđe hema indukuje konformacione promene okružujućeg proteina.CaM undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response.
CaM podleže konformacionoj promeni nakon vezivanja kalcijuma, što mu omogućava da se veže za specifične proteine za specifične response.Biochemical studies of intact transport complexes suggest that the conformational changes in the NBDs are relatively small.
Biohemijske studije netaknutih transportnih kompleksa sugerišu da su konformacione promene NB domena relativnom male.These interactions induce a conformational change in the receptor structure, which triggers the activation of various intracellular signaling pathways.
Te interakcije indukuju konformacionu promenu strukture receptora, koja inicira aktivaciju raznih intraćelijskih signalnih puteva.The"power stroke", that is, ATP binding that induces NBD dimerization andformation of the ATP sandwich, drives the conformational changes in the TMDs.
ATP vezivanje koje indukuje NBD dimerizaciju i formiranje ATP sendviča,je pogonska sila konformacionih promena u TM domenima.A model that describes the conformational changes in the nucleotide-binding domain(NBD) as a result of ATP binding and hydrolysis is the ATP-switch model.
Model koji opisuje konformacione promene u domenu vezivanja nukleotida( NBD) usled vezivanja ATP i hidrolize je model ATP-prekidača.A specific nonlinear optical technique called second-harmonic generation(SHG)has been recently applied to the study of conformational change in proteins.
Specifična nelinearna optička tehnika koja se naziva sekundarno-harmoničko generisanje( SHG)je nedavno bila primenjena na studiranje konformacionih promena proteina.Reversible phosphorylation results in a conformational change in the structure in many enzymes and receptors, causing them to become activated or deactivated.
Reverzibilna fosforilacija rezultuje u konformacionim promenama strukture mnogih enzima i receptora, što dovodi do njihove aktivacije i deaktivacije.When bound, these metabolites do not participate in catalysis directly, but they are still essential:they lead to conformational changes in a concrete part of the enzyme.
Kad su vezani, ovi metaboliti ne učestvuju direktno u katalizi, mada su oni esencijalni:oni dovode do konformacionih promena u konkretnom delu enzima.Resonance is distinguished from tautomerism and conformational isomerism, which involve the formation of isomers, thus the rearrangement of the nuclear positions.
Rezonancija se razlikuje od tautomerije i konformacionog izomerizma, koji se sastoje od formiranja izomera, te dolazi do preuređenja pozicija nukleusa.The transport cycle is initiated by binding of substrate to the high-affinity site on the TMDs,which induces conformational changes in the NBDs and enhances the binding of ATP.
Transportni ciklus se inicira vezivanjem supstrata za mesto vezivanja visokog afiniteta na TMD,što indukuje konformacione promene u NBD domenima i pospešuje vezivanje ATP.Changes in quartary structure can occur through conformational changes within individual subunits or through reorientation of the subunits relative to each other.
Промене у кватернарној структури се могу појавити током конформационих промена у појединачној подјединици или током реоријентације једне подјединице у односу на другу.The Q loop is presumed to be involved in the interaction of the NBD and TMD,particularly in the coupling of nucleotide hydrolysis to the conformational changes of the TMD during substrate translocation.
Smatra se da Q petlja učestvuje u interakciji NBD i TMD,posebno u sprezi nukleotidne hidrolize i konformacionih promena TMD tokom translokacije supstrata.They are activated in response to a conformational change in the GPCR, exchanging GDP for GTP, and dissociating in order to activate other proteins in a particular signal transduction pathway.
Oni se aktiviraju u responsu na konformacionu promenu G protein-spregnutog receptora, razmenjuju GDP za GTP, i disociraju se da bi aktivirali druge proteine u putu prenosa signala.This model proposes that the initial interaction between enzyme and substrate is relatively weak, butthat these weak interactions rapidly induce conformational changes in the enzyme that strengthen binding.
Po tom modelu inicijalna interakcija između enzima i supstrata je relativno slaba, alite slabe interakcije brzo indukuju konformacione promene enzima koje pojačavaju vezivanje.Receptor binding induces a global conformational change that involves the movement of the two arrestin domains and the release of its C-terminal tail that contains clathrin and AP2 binding sites.
Vezivanje za receptor indukuje globalnu konformacionu promenu koja obuhvata pomeranje dva domena arestina i oslobađanje njegovog C-terminusa koji sadrži klatrin i AP2 mesto vezivanja.They are notable for their unusual mechanism of action,in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt its active site.
Oni su osobeni po svom neobičnom mehanizmu dejstva, u kome oni ireverzibilnoinhibiraju svoje ciljne proteaze, i pri tom podležu znatnoj konformacionoj promeni da bi se prilagodili obliku aktivnog mesta.The structures indicated that the inhibitory mechanism involved an unusual conformational change and prompted the subsequent structural focus of serpin studies.
Strukture su pokazale da inhibitorni mehanizam obuhvata neobičnu konformacionu promenu i podstakle su dalji strukturni fokus na izučavanju serpina.Although a common mechanism has been suggested, the order of substrate binding,nucleotide binding and hydrolysis, and conformational changes, as well as interactions between the domains is still debated.
Mada je predložen zajednički mehanizam, redosled vezivanja supstrata,nukleotida, hidrolize, i konformacionih promena, kao i interakcija između domena su još uvek predmet aktivne debate.These proteins harness the energy of ATP binding and/or hydrolysis to drive conformational changes in the transmembrane domain(TMD) and consequently transport molecules.
Ovi proteini koriste energiju ATP vezivanja i/ ili hidrolize za izvršavanje konformacionih promena u transmembranskom domenu( TMD) i konsekventno za transport molekula.Dynamins polymerize around the neck of an incoming vesicle, andtheir phosphorylation by c-SRC provides the energy necessary for the conformational change allowing the final"pinching off" from the membrane.
Dinamini se polimerizuju oko vrata ulazećih vezikula, injihova fosforilacija c-SRC kinazom daje energiju koja je neophodna za konformacionu promenu kojom se ostvaruje finalno odvajanje od membrane.
