Examples of using Prasterone in English and their translations into Vietnamese
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Prasterone is a steroid hormone.
It is not known whether prasterone is safe for long-term use.
Prasterone can be used to increase DHEA and DHEA sulfate levels in adrenal insufficiency and older age.
For several decades now, DHEA, marketed under the name Prasterone, has been used in Europe to treat menopause related depression.
Prasterone and prasterone sulfate are readily available in the United States, where they are sold as over-the-counter dietary supplements.[64].
Estradiol valerate is also widely available in combination with prasterone enantate(DHEA enantate) under the brand name Gynodian Depot.[1].
Acolbifene/prasterone List of investigational hormonal agents§ Estrogenics.
It is a component of Gynodian Depot, a combination formulation of 4 mg estradiol valerate and200 mg prasterone enanthate in oil for depot intramuscular injection that is used in the treatment of menopausal symptoms and is marketed in Europe and South America.
Prasterone enanthate is available only as a combination formulation of 4 mg estradiol valerate and 200 mg prasterone enanthate in oil for depot intramuscular injection.[12][2][3].
A positional isomer of prasterone which may have similar biological activity is 4-dehydroepiandrosterone(4-DHEA).[45].
Prasterone sulfate is available in Japan, Italy, Portugal, Argentina, and China.[1][13] Brand names include Astenile, Dastonil, Di Luo An, Dinistenile, Levospa, Mylis, Sinsurrene, and Teloin.[9][13].
A long-lasting ester prodrug of DHEA, prasterone enanthate, is used in combination with estradiol valerate for this indication.
Prasterone is the generic name of DHEA in English and Italian and its INN, USAN, and DCIT,[ 1][ 61][ 62][ 63] while its generic name is prasteronum in Latin, prastérone in French and its DCF, and prasteron in German.[62].
Some researchers believe prasterone supplements might actually raise the risk of breast cancer, prostate cancer, heart disease, diabetes,[1] and stroke.
Prasterone enanthate, in combination with estradiol valerate at the dosages used clinically, has no masculinizing side effects.[1] This is in contrast to combinations of estrogens with other androgens, such as testosterone esters.
In the United States, prasterone or prasterone sulfate have been advertised, under the names DHEA and DHEA-S, with claims that they may be beneficial for a wide variety of ailments.
Prasterone enanthate is a prodrug of prasterone in the body.[1][2][3] It is completely hydrolyzed into prasterone and heptanoic acid(enanthic acid) following absorption from the tissue depot after intramuscular injection.
Within 30 days, 91% of a dose of prasterone enanthate is eliminated.[1] Approximatley 94% is excreted in urine and 6% in feces.[1] Prasterone enanthate is eliminated mainly in the form of metabolites and conjugates.[1].
Prasterone may stimulate tumor growth in types of cancer that are sensitive to hormones, such as some types of breast, uterine, and prostate cancer.[27] Prasterone may increase prostate swelling in men with benign prostatic hyperplasia(BPH), an enlarged prostate gland.[2].
The combination of estradiol valerate and prasterone enanthate was developed as early as 1966 and was introduced for medical use in 1975.[1][2] The formulation is marketed widely throughout Europe, and is also available in several Latin American countries and in Egypt.[ 3][ 4][ 5][ 6][ 7] It is not available in any predominantly English-speaking countries.
Prasterone has been reported to possess few or no side effects even at very high dosages(e.g., 50 times the recommended over-the-counter supplement dosage).[33] However, it may cause masculinization and other androgenic side effects in women and gynecomastia and other estrogenic side effects in men.[33].
Levels of DHEA peak at about 9 ng/mL within 1 to 4 days of an injection of prasterone enanthate.[1] Subsequently, DHEA levels return to baseline by about 18 days following the injection.[1] Prasterone enanthate has an elimination half-life of about 9 days.[1] The plasma half-life of DHEA/prasterone enanthate following an intravenous injection is about 44 minutes.[1] The half-lives of DHEA metabolites range up to 3.6 days.[1].
Although prasterone can reliably increase testosterone levels in women, this isn't similarly the case in men.[1] A high dosage of 1,600 mg/day prasterone in men for 4 weeks was found to increase DHEA and androstenedione levels but did not significantly affect testosterone levels.
Prasterone may promote tamoxifen resistance in breast cancer.[26] It may also increase the risk of uterine and prostate cancers due to metabolism into estrogens and androgens, respectively.[2] Patients on hormone replacement therapy may have more estrogen-related side effects when taking prasterone.
Prasterone is sometimes used as an androgen in menopausal hormone therapy.[9] In addition to prasterone itself, a long-lasting ester prodrug of prasterone, prasterone enanthate, is used in combination with estradiol valerate for the treatment of menopausal symptoms under the brand name Gynodian Depot.[ 10][ 11][ 12][ 13][ 14][ 15].