Compared with infected wild-type mice, heterozygous Eprs+/- mice infected with PR8 had decreased amounts of antiviral cytokines and increased amounts of virus.
Even in the wild type background, the analogous de novo increase of DNA methylation can be induced in trans by chromosomes with reduced DNA methylation.
In both wild-type and ErbB-mutation-positive cohorts, afatinib gave rise to superior PFS(Figure) and OS compared to erlotinib, although this effect was more pronounced in the mutant group.
Compared with the wild-type protein, the R47H and R62H TREM2 mutant proteins were less effective at promoting microglial survival or stimulating cytokine production.
LSST gene knockout mice revealed that lymphocyte homing of theperipheral lymph nodes decreased to about 50% of that in wild type mice. The number of lymphocytes in peripheral lymph nodes also decreased in the knockout mice.
In addition, there were no significant differences between wild-type and KO mice in locomotor activity, social interaction, hot plate test performance, fear conditioning, depression-like behavior, and Y-maze test performance.
WT: wild type, HT: transgenic In addition, the result of gene-expression analysis revealed that seven genes in the life-related gene cluster had reduced expression.
Zebrafish Retina Development| Okinawa Institute of Science andTechnology Graduate University OIST This figure shows the differences between a wild type zebrafish, labeled wt, and the SLBP mutant used in this experiment.
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