We further showed that knockdown of PP2A or inhibition of PKCζ orceramide synthesis prevented glucocorticoid-induced glucose intolerance in wild-type mice.
左列)野生型マウスの骨髄は丸い血液細胞で構成されている。
The bone marrow of wild-type mice is formed of round blood cells(right column).
After parabiosis, secreted PCSK9 was transferred to the circulation of wild-type mice and reduced the number of hepatic LDLRs to nearly undetectable levels.
The chimeric mouse is bred with a wild-type mouse, and the offspring that are capable of passing the targeting vector-derived mutation to the next generation is the knockout mouse..
The cell that has incorporated the targeting vector into its gene is selected by screening,mixed with the embryo of wild-type mouse through aggregation method, and implanted into the recipient female mouse..
In our investigation of the protein targets and functional impact of S-nitrosylation in the CNS under physiological conditions,we identified 269 S-nitrosocysteine residues in 136 proteins in the wild-type mouse brain.
When the mouse is raised in a light-dark cycle, the peak of its body temperature and spontaneous activity during the phases of its circadianrhythm appears 2-3 hours later than that of wild-type mouse(hence"eveningness").
Return to the Top Page Collagen XVII is indispensable for maintenance of hair follicle stem cells As mice usually have a life expectancy of 24 to 34 months,the hair follicles of wild-type mice that can live longer were examined for a long time, such as for 12, 24, and 28 months.
D, it can be seen that, at Hour 4 after the CLP, the BMMCs derived from a CD300D gene-deficient mouse(CD300a- CFSE+ cells) showed production of a significantlylarger amount of TNF-α than the BMMCs derived from a wild-type mouse(CD300a+CFSE+ cells).
When the viral vector carrying a gene for neprilysin, an enzyme responsible for degradation of amyloid-β peptides(Aβ) that cause Alzheimer's disease was administered into Alzheimer's disease model mice, the amounts of amyloids and Aβ oligomers which have strong neurotoxicity were reduced in the brain, and the impaired learning andmemory function was successfully restored to the level of wild-type mice.
In joint research with the Center,our company was unable to obtain antibodies for this marker with an existing wild-type mouse; however, using GANP® mice that we possess, we were able to obtain antibodies with extremely high specificity.
In comparing the number of USV calls measured for 5 minutes from 6 day old mouse pups separated from their mothers,the pups with older wild type father mice aged 12 months or more showed a significant reduction in the number of USV calls than from the pups with young 3 month old wild type father mice.
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