Voorbeelden van het gebruik van Braf in het Engels en hun vertalingen in het Nederlands
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BRAF mutations, all in exon 15,
The majority of subjects had a BRAF V600E mutation 85.
CRAF-1, and BRAF.
Vemurafenib is an inhibitor of BRAF serine-threonine kinase.
All patients with BRAF mutant tumours were previously treated with a BRAF inhibitor.
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Mutations of the BRAF gene can cause certain inherited diseases and birth defects.
Patients were enrolled regardless of their baseline BRAF mutation status.
The majority of subjects had BRAF V600E mutation-positive melanoma 89.
Therefore other treatment options should be considered before treatment with the combination in this prior BRAF inhibitor treated population.
Oncogenic mutations in BRAF lead to constitutive activation of the RAS/RAF/MEK/ERK pathway.
Before taking trametinib, patients must have confirmation of BRAF V600 mutation using a validated test.
The incidence of BRAF exon 15 mutation in the wild-type KRAS(exon 2) population was approximately 8.
Trametinib inhibits activation of MEK by BRAF and inhibits MEK kinase activity.
Patients with BRAF V600E mutant melanoma were not required to have received prior BRAF inhibitor therapy.
for BRAF mutant with prior BRAF treatment.
Only patients with BRAF V600E or V600K mutation positive tumours were eligible for study participation.
The safety of Cotellic in combination with vemurafenib has also been evaluated in 129 patients with advanced BRAF V600 mutated melanoma in Study NO25395.
Estimated from 16,403 melanomas with annotated BRAF codon 600 mutations in the public COSMIC database,
whose melanoma had a BRAF V600 mutation.
Most patients(87%) in the ITT population had BRAF V600E mutation and 12% of patients had BRAF V600K.
metastatic melanoma with a BRAF V600 mutation see sections 4.4 and 5.1.
All patients were required to have advanced melanoma with BRAF V600 mutations according to the cobas 4800 BRAF V600 Mutation Test.
safety of dabrafenib have not been established in patients with wild-type BRAF melanoma therefore dabrafenib should not be used in patients with BRAF wild-type melanoma see sections 4.4 and 5.1.
Non-clinical and clinical studies with retrospective sequencing analyses have shown that the test also detects the less common BRAF V600D mutations and V600K mutations with lower sensitivity.
The most commonly observed BRAF mutation is V600E which accounts for approximately 90% of the BRAF mutations that are seen in melanoma.
in a gene called BRAF, and that has spread to other parts of the body
In patients with BRAF and NRAS mutation positive melanoma, administration of trametinib resulted
