Примеры использования Cardiomyocytes на Английском языке и их переводы на Русский язык
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Myofibrils were clearly defined in most cardiomyocytes.
Most secretory and contractile cardiomyocytes were in a state of hyperfunction.
Further, in the contracting hEBs,64-89% of cells were cardiomyocytes.
These patient-specific cardiomyocytes recapitulated the clinical presentation of the'Long QT'phenotype 13.
Here we review the current progress in using iPSC-derived cardiomyocytes to model human CVDs.
Shortly after birth, human cardiomyocytes cease proliferating and exhibit a very limited regenerative capacity.
Several studies have focused on developing methologies to obtain more mature cardiomyocytes derived from iPSCs 34.
It is to be noted that iPSC-derived cardiomyocytes are morphologically and electrophysiologically immature compared to human adult counterparts.
The investigated drugs exhibit a normalizing influence on the ratio between sFA and usFA in cardiomyocytes of the hypertensive rats.
These studies clearly established iPSC-derived cardiomyocytes as a powerful tool for drug discovery and personalized medicine 15.
Bava infarction- striated heart muscle,which in turn consists of a fairly dense cluster of specific muscle cells- cardiomyocytes.
Induced pluripotent stem cells(iPS)can differentiate into cardiomyocytes via mechanisms involving the aforementioned cytokines.
A stereological test revealed the post-exercise increase of the relative volume of both conductive,and contractile cardiomyocytes in dogs See the Table.
It remains unclear whether diseased iPSC-derived cardiomyocytes show disease phenotypes in vitro and how similar in vitro phenotypes are to their clinical equivalents.
The phenotype of these channels is discussed in relation with the same channels from other cells, including cardiomyocytes, brain astrocytes and kidney macula densa.
By differentiating the patient-specific iPSCs into cardiomyocytes, scientists can generate iPSC-based"disease in a dish" models and use them to better understand disease mechanism.
It has been established that the implantation of microspheres made from gelatin enables growth of cerebral neurons,skeleton myoblasts and cardiomyocytes to take place 81.
A quantitative analysis of the two types of granules with peptides in atrial cardiomyocytes was performed by counting in fields of vision(38×38 µm) 24, 28.
Newly differentiated cardiomyocytes possess the mechanical and electric properties of functionally cardiomyocytes, which improve cardiac function after MI 12.
After two weeks of salt loading there were detected morphometric changes in granules of the right atrial secretory cardiomyocytes, containing immunoreactive material.
The current pulses produce the so-called«cage drivers», and cardiomyocytes, muscular cells, use them to play cuts and relaxation at the right moments in time.
The increase in fatty acids leads to the change of ionic pump functioning, sodium andcalcium excess in a cell that breaks the capability of cardiomyocytes to relax and contract.
Depletion of mAKAP ordisruption of its targeting to the perinuclear(in cardiomyocytes) region altered the stability of HIF-1 and transcriptional activation of genes associated with hypoxia.
Under suitable conditions, iPSCs could long-term propagate in undifferentiated state or differentiate into many other cell types,including functional cardiomyocytes 16,17.
It is interesting to note that we observed the similar morphological picture when we studying cardiomyocytes of the rat Langendorf isolated heart, Mexidol being administered at the same dose- 25 mg/kg 18.
Pretreatment of cardiac scars with gene transfer of VEGF in addition to the Gata4, Mef2c, and Tbx5(GMT)enhanced the transdifferentiation of rat fibroblasts into(induced) cardiomyocytes 50.
Patient-specific induced pluripotent stem cell cardiomyocytes(iPSC-CMs) from a ten-member family cohort carrying a hereditary HCM missense mutation(Arg663His) in the MYH7 gene were generated.
Such 3D cellular systems applied to human stem cells and their derivatives can be utilized to investigate variousheritable disorders affecting hepatocytes, neurons, cardiomyocytes etc.
HiPS and hES cell-derived cardiomyocytes share similar cardiac gene expression patterns, proliferation, sarcomeric organizations and they exhibited similar responsive pattern to β-adrenergic stimulation.
In the past decades, many cell types have been used for cardiac regeneration, including skeletal myoblast,primary cardiomyocytes, mesenchymal stem cells(MSCs) and embryonic stem cells(ESCs) 5-9.