Примеры использования Phosphorylates на Английском языке и их переводы на Русский язык
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Once activated, PI 3-kinase phosphorylates PIP2 to form PIP3.
Cdk1 phosphorylates the nuclease Sae2, allowing resection to initiate.
Upon activation of the SAC Bub1 directly phosphorylates APC/C's coactivator Cdc20.
Aurora B also phosphorylates myosin II regulatory light chain at the cleavage furrow.
AKT, which is referred to as protein kinase B, phosphorylates FOXO1 and accumulates in the cytosol.
PKB then phosphorylates several target proteins, including glycogen synthase kinase 3 GSK-3.
This kinase translocates to the nucleus of the stimulated cells,where it phosphorylates nuclear targets.
It is thought that PINK1 phosphorylates Parkin ubiquitin ligase at S65 which initiates Parkin recruitment at the mitochondria.
ATM directly interacts with the NBS1 subunit and phosphorylates the histone variant H2AX on Ser139.
It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis.
In a further step, some NAD+ is converted into NADP+ by NAD+ kinase, which phosphorylates NAD.
Mps1 phosphorylates Mad1 both in vitro and in vivo and is thought to regulate Mad1 and Mad2 localization to kinetochores and their interaction dynamics.
This rise activates AMP-activated protein kinase, which phosphorylates ACC and thereby inhibits fat synthesis.
Activated CHK2 phosphorylates phosphatase CDC25A, which is degraded thereupon and can no longer dephosphorylate CDK1-cyclin B, resulting in cell-cycle arrest.
Rb can be downregulated by activating the sonic hedgehog pathway, which phosphorylates the proteins and reduces gene transcription.
Moreover, Bub1 phosphorylates and thus inhibits Cdc20 directly, while in yeast Mad2 and Mad3, when bound to Cdc20, trigger its autoubiquitiniation.
IFNAR2 gene stimulates binding andactivation of protein kinase Janus receptor, which phosphorylates several proteins for example, STAT and STAT1.
Once localized at the mitochondria, PINK1 phosphorylates Parkin at S65, homologous to the site where ubiquitin was phosphorylated, which activates Parkin by inducing dimerization and an active state.
It is caused by point mutation in c.899C>T gene coding for FAM20C protein that binds calcium and phosphorylates proteins involved in bone and teeth mineralization.
BUB3 also phosphorylates: CDC20(activator) and thereby inhibits the ubiquitin ligase activity of APC/C. MAD1L1, which usually interacts with BUB1 and BUBR1, and in turn the BUB1/BUB3 complex interacts with MAD1L1.
When the cell is treated with TGF-β, HIPK2,a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway see"The Daxx Pathway" figure.
An exception to the general mechanism of regulation are receptors for tumor growth factor TGF- β( tumor growth factor)- Kinase TGF- β phosphorylates serine or threonine, but not tyrosine.
There are two types of CaM kinase: Specialized CaM kinases,such as the myosin light chain kinase that phosphorylates myosin, causing smooth muscles to contract Multifunctional CaM kinases, also collectively called CaM kinase II, which play a role in neurotransmitter secretion, transcription factor regulation, and glycogen metabolism.
This protein then begins a phosphorylation cascade, culminating in the activation of mitogen-activated protein kinase(MAPK),which enters the nucleus and phosphorylates various nuclear transcription factors such as Elk1.
If the DSB can not be repaired during this rapid response,ATM additionally phosphorylates MDM2 and p53 at Ser15. p53 is also phosphorylated by the effector kinase CHK2.
These family members function in a protein kinase signal transduction cascade,where an activated MAPK kinase kinase(MAP3K) phosphorylates and activates a specific MAPK kinase(MAP2K), which then activates a specific MAPK.
Muscle cells use CreatinePhosphate, a phosphorylated form of Creatine, to store energy.
GSK-3 is responsible for phosphorylating(and thus deactivating) glycogen synthase.
These dimers phosphorylate each other and enhance catalytic activity of the kinase.
Active cyclin D-cdk complexes phosphorylate retinoblastoma protein(pRb) in the nucleus.