Примери за използване на Aneuploidy на Английски и техните преводи на Български
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Aneuploidy occurs in group S.
It will also identify aneuploidy.
Aneuploidy is a common characteristic of cancer cells.
Fetal ultrasonographic findings indicating an increased risk of aneuploidy.
If aneuploidy is present, small excesses or deficits in counts of the affected chromosome will be detected.
Additional markers are used to detect aneuploidy of the sex chromes.
If there is an extra or a missing chromosome inany of these pairs, it is known as an aneuploidy.
However it is still controversial if aneuploidy is a contributing cause or merely a consequence of neoplastic transformation.
Arrested embryos: The major chromosomal abnormality detected in arrested monospermic embryos is polyploidy(43%),followed by mosaicism and aneuploidy.
Aneuploidy is an established risk factor for teratogenicity, embryotoxicity or spontaneous abortion, and impaired male fertility.
To create the model, the scientists mixed eight cell-stage mouse embryos with normal cells with embryos with abnormal cells,using the molecule“reversine” to achieve aneuploidy.
This sort of abnormality,called aneuploidy, is the most common cause of miscarriages, accounting for 50 percent, and the risk of it rises with age.
The CHMP considers that the clinical evidence within the cases reported by the MAHs concerning the consequences of aneuploidy in humans does not allow drawing definitive conclusions.
Aneuploidy is a risk factor for harm to the developing fetus, reduced fertility in men and in theory could increase the risk of developing cancer.
These include polyploidy, that is, the formation of a genome with a triple ormore chromosome set, and aneuploidy- the number of chromosomes in the genome is not a multiple of the haploid.
Genotoxic mechanisms, such as aneuploidy, involving cell division and non-DNA targets, are known to occur above a certain threshold of exposure.
This allows the embryologist screen for a wide range of genetic mutations known as aneuploidy(missing or extra chromosomes) that could cause implantation failure.
A range of product for aneuploidy testing provides different combinations of STR markers for the detection of the most common trisomies.
These PSURs should include a report compiling continuous monitoring of any safety signal correlated with aneuploidy and pregnancy on accidental exposure to the drug.
Aneuploidy is considered as a risk factor for teratogenicity, embryo/foeto-toxicity, spontaneous abortion, and impaired male fertility and a potential risk factor for cancer.
Taking the totality of data into account,the CHMP considered that causality cannot be excluded and that aneuploidy should be considered as a cancer risk factor on theoretical grounds.
Aneuploidy, the presence of an abnormal number of chromosomes, is one genomic change that is not a mutation, and may involve either gain or loss of one or more chromosomesthrough errors in mitosis.
It was concluded that M1(SL18.0740) is devoid of mutagenic(gene mutations) and clastogenic(structural chromosome damage) potential, butis able to induce aneuploidy(numerical chromosome damage).
Italy requested the CHMP,under Article 31 of Directive 2001/83/EC, to assess the above concerns regarding aneuploidy and its impact on the benefit-risk balance for TCC containing medicinal products for systemic use.
Aneuploidy is a modification in the number of chromosomes and loss of heterozygosity, which is recognized as a risk factor for teratogenicity, embryotoxicity/ spontaneous abortion, impaired male fertility, when impacting germ cells and a potential risk factor for cancer when impacting somatic cells.
In the majority of cases of full trisomy 16(where the trisomy occurs in all of the body's cells), this aneuploidy results in spontaneous miscarriage during the first trimester and has been shown to account for 12% of chromosomally abnormal miscarriages.
Since no relevant genetic toxicology studies were previously performed with the aglycone metabolite SL59.0955, complementary studies(chromosome damage assays) were performed in order to investigate the genotoxic profile of this metabolite andits ability to induce aneuploidy in nonclinical in vitro(up to 600 µg/mL) and in vivo(up to 150 mg/kg).
The CHMP reviewed the evidence, including the opinions of experts in the field of medicines safety,and concluded that aneuploidy could occur with M2 at levels not much greater than those seen after recommended doses of thiocolchicoside taken by mouth.
Continuous monitoring of any safety signal correlated with aneuploidy(i.e. teratogenicity, embryo-foetal toxicity/ spontaneous abortion, impaired male fertility and cancer) and pregnancy reporting to collect structured data on accidental exposure to the drug should be performed.