Примери за използване на Cmax and cmin на Английски и техните преводи на Български
{-}
-
Medicine
-
Colloquial
-
Official
-
Ecclesiastic
-
Ecclesiastic
-
Computer
The AUC, Cmax and Cmin of phenytoin were decreased by 22%, 20% and 29% respectively.
At therapeutic dosages a dosage of 300 mg twice daily, the mean(CV)steady state Cmax and Cmin of abacavir are approximately 3.00 µg/ml(30%)and 0.01 µg/ml(99%), respectively.
The AUC, Cmax and Cmin of amprenavir were increased by 130%, 40% and 125% respectively.
When APTIVUS, co-administered with low dose ritonavir, was co-administered with 20 ml of aluminium- and magnesium-based liquid antacid,tipranavir AUC12h, Cmax and Cmin were reduced by 25-29%.
The steady-state AUC, Cmax and Cmin of the active carbamazepine epoxide metabolite remained unchanged.
Co-administration of omeprazole(40 mg once daily)with atazanavir 300 mg/ritonavir 100 mg to healthy volunteers resulted in a substantial reduction in atazanavir exposure(approximately 75% decrease in AUC, Cmax and Cmin).
Delavirdine: the AUC, Cmax and Cmin of delavirdine were decreased by 61%, 47%and 88% respectively when given with amprenavir.
As demonstrated in a doseranging evaluation in 113 HIV-negative healthy male and female volunteers,ritonavir increases AUC012h, Cmax and Cmin and decreases the clearance of tipranavir.
CYP3A4 and CYP2B6 induction The steady-state AUC, Cmax and Cmin of the active carbamazepine epoxide metabolite remained unchanged.
Cmax and Cmin at steady-state are 4.2and 0.3 ng/ml, respectively, for a dose of 0.5 mg, and 8.2 and 0.5 ng/ml, respectively, for 1 mg.
Assessment of bioequivalence will be based on AUCτ, Cmax and Cmin applying similar statistical procedures as for the immediate release formulations.”.
As compared to a non-matched historical control group, co-administration of methadone and amprenavir resulted in a 30%, 27% and 25% decrease in serum amprenavir AUC, Cmax and Cmin respectively.
The decrease in AUC, Cmax, and Cmin was not mitigated when an increased dose of REYATAZ/ ritonavir(400/ 100 mg once daily) was temporally separated from omeprazole by 12 hours.
Digoxin: co-administration for 7 days of bosentan 500 mg twice daily with digoxin decreased the AUC, Cmax and Cmin of digoxin by 12%, 9% and 23%, respectively.
In the same study, the AUC, Cmax, and Cmin of amprenavir were increased 72%, 12%, and 483%, respectively, when compared to values after standard doses of amprenavir(1200 mg twice daily).
Co-administration of omeprazole(40 mg once daily)with atazanavir 300 mg/ritonavir 100 mg to healthy volunteers resulted in a substantial reduction in atazanavir exposure(approximately 75% decrease in AUC, Cmax, and Cmin).
Mean(% CV) AUC, Cmax and Cmin of saquinavir in patients following multiple dosing of Invirase, saquinavir soft capsules, Invirase/ritonavir, and saquinavir soft capsules/ritonavir.
Concomitant administration of omeprazole(40 mg, once daily) with atazanavir 300 mg/ ritonavir 100 mg in healthy volunteers resulted in a substantial decrease in atazanavir plasma concentrations(a decrease in approximately 75% of the AUC, Cmax and Cmin).
Steady state AUC, Cmax and Cmin increased in a less-than dose-proportional mannerand individual exposures overlapped substantially at 800 mg and 1,200 mg, suggesting diminished absorption at higher doses.
Based on data derived from a study in healthy volunteers, at a therapeutic dose of150 mg twice daily, mean(CV) steady-state Cmax and Cmin of lamivudine in plasma are 1.2 µg/ml(24%)and 0.09 µg/ml(27%), respectively.
In an open-label, non-fasting pharmacokinetic study,the AUC, Cmax and Cmin of lopinavir were decreased by 38%, 28% and 52% respectively when amprenavir(750 mg twice daily) was given in combination with Kaletra(400 mg lopinavir+ 100 mg ritonavir twice daily).
Based on data derived from a study in healthy volunteers, at a therapeutic dose of 150 mg twice daily,mean(CV) steady-state Cmax and Cmin of lamivudine in plasma are 1.2 µg/ml(24%)and 0.09 µg/ml(27%), respectively.
Percentiles and PK parameter values at clinically relevant concentrations(Cmax and Cmin) for MBC, EBC and AGC patients treated with the approved q1w and q3w dosing regimens are shown in Table 14(Cycle 1), Table 15(steady-state), and Table 16(PK parameters).
Based on data derived from a study in healthy volunteers, at a therapeutic dose of 150 mg twice daily, mean(CV)steady-state Cmax and Cmin of lamivudine in plasma are 1.2 μg/ml(24%)and 0.09 μg/ml(27%), respectively.
The population predicted PK exposure values(median with 5th- 95th Percentiles) and PK parameter values at clinically relevant concentrations(Cmax and Cmin) for MBC, EBC and AGC patients treated with the approved q1w and q3w dosing regimens are shown in table 14(cycle 1), table 15(steadystate), and table 16(PK parameters).
Children 6 to 11 years of age(n=9) receiving fosamprenavir/ ritonavir 18/ 3 mg/kg twice daily had 26% higher AUC(0-24)and similar Cmax and Cmin values when compared to the historical adult population receiving fosamprenavir/ ritonavir 700/ 100 mg twice daily.
The Cmax, AUC and Cmin of amprenavir were unchanged.
The Cmax, AUC and Cmin of amprenavir were unchanged.
The Cmin, Cmax and AUC0-24 were all significantly higher with the BID regimen compared with the TID regimen.
Daclatasvir Cmax, AUC, and Cmin increased in a near dose-proportional manner.