Примери за използване на Cmax decreased на Английски и техните преводи на Български
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Cmax decreased by 31%.
The AUC of pioglitazone increased by 20% while Cmax decreased by 18%.
Tenofovir Cmax decreased by 12% and AUC increased by 27% with a high fat meal.
Clarithromycin: the AUC and Cmin of clarithromycin were unaltered and the Cmax decreased by 10% when given with amprenavir.
Lamivudine Cmax decreased by 19% with a high fat meal, while AUC was not significantly affected.
For metformin, AUC decreased by 12% and Cmax decreased by 26% compared to fasting conditions.
In patients with ESRD undergoing haemodialysis,the AUC0-∞ of total aprepitant decreased by 42% and Cmax decreased by 32%.
The AUC of ertugliflozin decreased by approximately 13%, and Cmax decreased by approximately 21% compared to subjects with normal hepatic function.
Co-administration of lamivudine with food results in a delay of tmax and a lower Cmax(decreased by 47%).
The AUC and Cmin of amprenavir were increased by 64% and 508% respectively and the Cmax decreased by 30% when ritonavir(100 mg twice daily) was coadministered with amprenavir(600 mg twice daily) compared to values achieved after 1200 mg twice daily doses of amprenavir.
For the sum of unbound enzalutamide plus the unbound active metabolite,the AUC increased by 77% while Cmax decreased by 19%.
Ritonavir: the AUC and Cmin of amprenavir were increased by 64% and 508% respectively and the Cmax decreased by 30% when ritonavir(100 mg twice daily) was co-administered with amprenavir capsule(600 mg twice daily) compared to values achieved after 1200 mg twice daily doses of amprenavir capsules.
Co-administration of lamivudine with food resulted in a delay of tmax and a lower Cmax(decreased by up to 47%).
Comparable bioavailability(AUC) of fentanyl was achieved with and without oxymetazoline, while fentanyl Cmax decreased and Tmax increased by a factor two when oxymetazoline was administered.
A single dose administration of lisinopril 20 mg with liraglutide resulted in a reduction of lisinopril AUC by 15%; Cmax decreased by 27%.
Similarly, for CGP52421 and CGP62221 AUC increased to 19000 and29200 ng*h/ml and Cmax decreased to 172 and 455 ng/ml, respectively.
A single dose administration of digoxin 1 mg with liraglutide resulted in a reduction of digoxin AUC by 16%; Cmax decreased by 31%.
Following coadministration with 2 consecutive doses of dulaglutide,sitagliptin AUC(0-τ) and Cmax decreased by approximately 7.4% and 23.1%, respectively.
In a clinical pharmacokinetic study in patients, co-administration with 200 mg itraconazole twice daily(a strong CYP3A4 inhibitor) had no clinically significant effect on the exposure of osimertinib(area under the curve(AUC)increased by 24% and Cmax decreased by 20%).
For the active moieties(sum of apalutamide plusthe potency adjusted active metabolite), Cmax decreased by 22% while AUC was again similar.
Following dulaglutide coadministration, S- and R-warfarin exposure andR-warfarin Cmax were unaffected, and S-warfarin Cmax decreased by 22%.
For the active moieties(sum of apalutamide plusthe potency adjusted active metabolite), Cmax decreased by 21% while AUC increased by 45%.
After coadministration of steady state digoxin with 2 consecutive doses of dulaglutide, overall exposure(AUCτ) andtmax of digoxin were unchanged; and Cmax decreased by up to 22%.
In patients with severe renal impairment, the AUC0-∞ of total aprepitant(unbound andprotein bound) decreased by 21% and Cmax decreased by 32%, relative to healthy subjects.
In patients with ESRD undergoing haemodialysis,the AUC0- of total aprepitant decreased by 42% and Cmax decreased by 32%.
Following coadministration of multiple dose dulaglutide with steady state metformin(immediate release formula[IR]),metformin AUCτ increased up to 15% and Cmax decreased up to 12%, respectively, with no changes in tmax.
Administration of a single dose of 1.5 mg cariprazine with a high-fat meal(900 to 1,000 calories) did not significantly affect the Cmax orAUC of cariprazine(AUC0-∞ increased by 12%, Cmax decreased by< 5% under fed condition versus fasting).
However the objecting EU Member States argued that the effect of food on Cmax may be formulationdependent in the case of diclofenac, andthat from the available evidence the potential difference in bioavailability(Cmax decrease of up to 70%) may reach such a high level so as to compromise the safe and effective use of the drug.
When taking the drug with fatty foods, the how to buy viagra pharmacokinetic index of Cmax decreases by at least 20%(sometimes up to 40%), it takes from 1.5 to 3 hours to achieve it.
Administration of vildagliptinwith food resulted in a decreased Cmax(19%).