Примери за използване на Decreased plasma на Английски и техните преводи на Български
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Significantly decreased plasma concentrations of simeprevir are expected.
Etravirine without boosted protease inhibitors decreased plasma dolutegravir concentration.
Atorvastatin significantly decreased plasma levels of totalC, LDL-C, triglycerides, and apolipoprotein B during the 26 week double-blind phase.
Growth hormone deficiency is associated with decreased plasma and extracellular volumes.
A risk of decreased plasma concentrations resulting in a loss of efficacy could be observed with coadministration of topiramate and St John's Wort.
Isavuconazole is a mild CYP2B6 inducer; co-administration of CRESEMBA may result in decreased plasma concentrations of CYP2B6 substrates.
St John's Wort decreased plasma concentrations of midazolam by about 20-40% associated with a decrease in terminal half life of about 15-17%.
Compounds that are substrates of these enzymes may have decreased plasma concentrations when co-administered with efavirenz.
Concomitant administration of dexamethasone with substances that are metabolised via CYP3A4 ortransported by P-gp could lead to increased clearance and decreased plasma concentrations of these substances.
In some studies chronic marijuana use has been shown to be associated with decreased plasma testosterone levels, but other studies have failed to reproduce these findings.
AUC:↓ 52%(↓ 33 to↓ 66) Cmax:↓ 45%(↓ 25 to↓ 59)(CYP3A4 induction) In a study of HIV infected intravenous drug users,co-administration of efavirenz with methadone resulted in decreased plasma levels of methadone and signs of opiate withdrawal.
Taking EDURANT in fasted condition orwith only a nutritional drink may result in decreased plasma concentrations of rilpivirine, which could potentially reduce the therapeutic effect of EDURANT(see section 4.2).
In a study of HIV infected intravenous drug users,co-administration of efavirenz with methadone resulted in decreased plasma levels of methadone and signs of opiate withdrawal.
Dosing recommendations for such combinations havenot been established and may result in decreased plasma concentrations of atazanavir, darunavir and/or the other antiretroviral agents that require pharmacoenhancement leading to loss of antiviral activity and development of resistance.
Administration of a single dose of eltrombopag 75 mg with a polyvalent cation-containing antacid(1524 mg aluminium hydroxide and1425 mg magnesium carbonate) decreased plasma eltrombopag AUC0- by 70%(90% CI: 64%, 76%) and Cmax by 70%(90% CI: 62%, 76%).
It is unknown whether a potential interaction would result in increased or decreased plasma concentrations, and thus patients should be monitored both for signs of toxicity and lack of efficacy of the narrow therapeutic index drug.
The coadministration of saxagliptin and CYP3A4/5 inducers, other than rifampicin(such as carbamazepine, dexamethasone, phenobarbital, and phenytoin) has not been studied andmay result in decreased plasma concentration of saxagliptin and increased concentration of its major metabolite.
Co-administration of EVOTAZ with medicinal products that are moderate to weak inducers of CYP3A may result in decreased plasma concentration of atazanavir and/or cobicistat, leading to loss of therapeutic effect and possible development of resistance to atazanavir.
EVOTAZ should not be used in combination with another antiretroviral that requires pharmacokinetic enhancement(i.e., another protease inhibitor or elvitegravir) since dosing recommendations for such combinations have not been established andmay result in decreased plasma concentrations of atazanavir and/or the other antiretroviral leading to loss of therapeutic effect and development of resistance.
In the first study(in prepubertal boys),Lescol 20 to 80 mg daily doses decreased plasma levels of total-C and LDL-C by 21% and 27%, respectively.
Taking INCIVO without food orwithout regard to the dosing interval may result in decreased plasma concentrations of telaprevir which could reduce the.
In the second study(in pubertal or postpubertal girls and boys),Lescol 20 to 80 mg daily doses decreased plasma levels of total-C and LDL-C by 22% and 28%, respectively.
Herbal preparations containing St John's wort(Hypericum perforatum)due to the risk of decreased plasma concentrations and reduced clinical effects of lopinavir and ritonavir(see section 4.5).
John' s wort(Hypericum perforatum)must not be used while taking efavirenz due to the risk of decreased plasma concentrations and reduced clinical effects of efavirenz(see section 4.5).
Herbal preparations containing St John's wort(Hypericum perforatum)due to the risk of decreased plasma concentrations and reduced clinical effects of ritonavir(see section 4.5).
Co-administration of rilpivirine with medicinal products that increase gastric pH may result in decreased plasma concentrations of rilpivirine which could potentially reduce the therapeutic effect of EDURANT.
In a 21-day study in HFrEF patients, Neparvis significantly increased urine ANP and cGMP andplasma cGMP, and decreased plasma NT-proBNP, aldosterone and endothelin-1 compared to baseline.
Hydrochlorothiazide should not be used for gestational oedema, gestational hypertension orpreeclampsia due to the risk of decreased plasma volume and placental hypoperfusion, without a beneficial effect on the course of the disease.
Concomitant treatment with strong CYP inducers(e.g. rifampicin, carbamazepine or phenytoin)should be avoided, as a risk for decreased plasma concentrations and decreased efficacy of vismodegib cannot be excluded(see also section 4.5).
Herbal preparations containing St John' s wort(Hypericum perforatum) must not be used while taking lopinavir andritonavir due to the risk of decreased plasma concentrations and reduced clinical effects of lopinavir and ritonavir(see section 4.5).