Примери за използване на Fatal overdose на Английски и техните преводи на Български
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What pills can be fatal overdose.
It is important to keep iron supplements out of reach of children to reduce the risk of fatal overdose.
The Committee considered the risk of fatal overdose with dextropropoxyphene.
Consider gastric lavage only if within one hour of a potentially fatal overdose.
They said my father's fatal overdose sparked my lifetime of criminal behavior.
Pulmonary edema is almost universal occurrence in fatal overdose.
Fatal overdoses of heroin, oxycodone's close cousin, have been skyrocketing{8} since 2007 across the country.
This characteristic is one of the main reasons that fatal overdoses of cannabinoids do not occur.
Taking benzodiazepines with pain medicine orsleeping pills can also lead to fatal overdose.
Rates of opioid-linked fatal overdoses have nearly doubled over the past decade and topped 70,000 in 2017, according to data released in November by the U.S.
Data assessed by the Committee highlighted that many of the cases of fatal overdoses seen have been accidental.
The risk of a fatal overdose is higher with barbiturates than other drugs as the difference between a safe dose and a deadly one is small.
The effects of PMA can a take a while to kick-in so there's a risk of the user double-dosing to compensate,risking a fatal overdose.
It's hard to get a firm count on fatal overdoses because the drug is new and doesn't always show up on initial post-mortem examinations, Howe said.
However, combining it with other substances, such as alcohol, can increase the sedative effects,possibly leading to a fatal overdose.
The risk of a person suffering a fatal overdose from marijuana is“extremely small,” and there are no reports of fatal overdoses in the scientific literature, according to the review.
As barbiturates are used more,the difference between a dose that causes the desired effect and that of a fatal overdose becomes narrower.
A substantial proportion of the fatal overdoses are accidental- occurring under normal conditions of use, for the licensed indication of painand there is a significant public health impact in relation to these cases alone.
Some people switched to heroin, which was cheaper, and later to synthetic opioids,which are more potent and more likely to lead to a fatal overdose.
A substantial proportion of the fatal overdoses are accidental- occurring under normal conditions of use, for the licensed indication of painand there is a significant public health impact in relation to these cases alone.
However, although illegal barbiturate use is rare,it remains an extremely dangerous drug to abuse because of the high risk of fatal overdose.
Based on the limited efficacy andthe significant risk of fatal overdose(in particular accidental overdose), the CHMP was of the opinion that the benefit/risk balance of dextropropoxyphene containing medicinal products was negative.
Attempt to overcome blockade: The attempt to overcome any naltrexone opioid blockade by administering large amounts of exogenous opioids is very dangerous andmay lead to a fatal overdose or life endangering opioid intoxication(e.g., respiratory arrest, circulatory collapse).
Whilst there is a risk of fatal overdose, the CHMP considered that it is limited for the parenteral dextropropoxyphene medicinal products, given the administration under hospital setting(given by healthcare professionals) and the classification of these medicinal products as narcotic prescription(in the Member State where the product is authorised) and the lack of evidence of fatal overdose particularly of accidental overdose. .
Although spontaneous reporting suggested that the safety signal concerning the overdose was not significant, other more complete data, particularly from forensic centres andnational mortality statistics confirmed that the risk of accidental fatal overdose under normal conditions of use associated with dextropropoxyphene containing products is of major concern, mainly due to their narrow therapeutic index and high case fatality.
In light of differences between Member States in terms of the number of fatal overdoses reported, the Committee also sought data from other sources available in Member States,including case reports of fatal overdose, data from poison centres, data from coroners' services, hospital statistics, national mortality statistics, and toxicology data from forensic services, from both published and unpublished research.
On the basis of evidence of harm from reports of fatal overdose, of divergent safety reviews and previous regulatory action taken in several Member States, the European Commission initiated a referral under Article 31(2) of Directive 2001/83/EC, as amended, to address this public health issue for medicinal products containing dextropropoxyphene and paracetamol, and therefore referred the matter to the CHMP on 30 November 2007.
On the basis of evidence of harm from reports of fatal overdose, of divergent safety reviews and previous regulatory action taken in several Member States, the European Commission initiated a referral under Article 31(2) of Directive 2001/83/EC, as amended, to address this public health issue for medicinal products containing dextropropoxyphene and paracetamol, and therefore referred the matter to the CHMP on 30 November 2007.
In view of the complex context in which cases of fatal overdose occurred under normal conditions of use and in view of the narrow therapeutic index and the potential for rapid death, the CHMP was of the opinion that the above proposed risk minimisation activities of narrowing the indication, reducing the pack sizes and/or introducing further safety warnings and contraindications(including those beyond the Product Information) would not be able to reduce the risks to an acceptable level.