Примери за използване на Major molecular на Английски и техните преводи на Български
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Major molecular response n.
Figure 1: Kaplan-Meier estimate of time to major molecular response(MMR).
(95% CI) Major Molecular Response b.
The secondary efficacy endpoints in CPCML were complete haematological response(CHR) and major molecular response(MMR).
Major molecular response All patients.
The primary efficacy endpoint was major molecular response(MMR) at 12 months.
Most major molecular file formats are supported.
Key efficacy endpoints were: complete cytogenetic response(CCyR),major cytogenetic response(MCyR) and major molecular response(MMR).
The rate of major molecular response(assessed in 41 patients with a CCyR) was 46% at 24 months.
After one year of treatment, 47%(116 out of 246)of patients treated with Bosulif had a major molecular response, compared with 37%(89 out of 241) of patients treated with imatinib.
The rate of major molecular response(all 25 treated patients with a CCyR) was 52% at 24 months.
Similarly, in a randomized, prospective study of 519 patients that compared dasatinib with imatinib,the rate of major molecular response at 12 months was 46% for dasatinib and 28% for imatinib(P< .0001).
The rate of major molecular response at 24 months was 45%(35% for imatinib-resistant patients and 74% for imatinib-intolerant patients).
Patients who re-initiate Tasigna therapy should have their BCR-ABL transcript levels monitored monthly until previous major molecular response or MR4 level is reestablished and every 12 weeks thereafter(see section 4.4).
Loss of major molecular response(MMR=BCR-ABL/ABL≤0.1%IS) will trigger treatment re-initiation within 4 weeks of when loss of remission is known to have occurred.
The effect of stopping treatment on long-term disease outcome after the achievement of a cytogenetic ormolecular response[including complete cytogenetic response(CCyR), major molecular response(MMR) and MR4.5] has not been investigated.
The rate of major molecular response(defined as BCR-ABL/control transcripts≤ 0.1% by RQ-PCR in peripheral blood samples) prior to crossover was 29% for dasatinib and 12% for imatinib.
Patients with confirmed loss of MR4(MR4= BCR-ABL/ABL≤0.01%IS) during the treatment-free phase(two consecutive measures separated by at least 4 weeks showing loss of MR4)or loss of major molecular response(MMR=BCR-ABL/ABL≤0.1%IS) must re-initiate treatment within 4 weeks of when loss of remission is known to have occurred.
Loss of major molecular response(MMR=BCR-ABL/ABL≤0.1%IS) or confirmed loss of MR4(two consecutive measures separated by at least 4 weeks showing loss of MR4(MR4=BCR-ABL/ABL≤0.01%IS)) will trigger treatment re-initiation within 4 weeks of when loss of remission is known to have occurred.
The main measure of effectiveness was the number of patients who had a‘major molecular response'(where the amount in the bone marrow of BCR-ABL, the protein produced by the Philadelphia chromosome, is greatly lowered).
Loss of major molecular response(MMR=BCR-ABL/ABL≤0.1%IS) in CML patients who received nilotinib as first- or second-line therapy, or confirmed loss of MR4(two consecutive measures separated by at least 4 weeks showing loss of MR4(MR4=BCR-ABL/ABL≤0.01%IS)) in CML.
The primary efficacy endpoint was the proportion demonstrating a major molecular response(MMR) at 12 months(48 weeks) in the bosutinib treatment group compared with that in the imatinib treatment group in the mITT population.
Major Components: large molecular weight silk fibroin protein.
Using a well-designed technique anda large-scale international collaborative process, we were able to answer one of the major questions in molecular geobiology”, says Hallmann.
Major targets are molecular complexes that readily give up or acquire a single electron, e.g., those with sulfhydryl/disulfides or with paramagnetic metals(iron, copper).
The following courses fulfill some of the requirements for a bachelor's degree with a major in biochemistry and molecular biology.
This is due to the lower molecular weight of the major fatty acids in coconut oil, which give it a lower melting point; typically right around room temperature.
Life Sciences major focuses on applied scientific research into molecular biological processes of'life' mostly from a biomedical angle.
Major cytogenetic response, haematological response, molecular response(evaluation of minimal residual disease), time to accelerated phase or blast crisis and survival are main secondary endpoints.
Beyond proving its safety, another major hurdle is how to deliver the molecular machinery to cells that need it in sufficient amounts to treat a disorder.