Примери за използване на Methaemoglobin на Английски и техните преводи на Български
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Formation of methaemoglobin.
Description of selected adverse reactions Inhaled nitric oxide therapy may cause an increase in methaemoglobin.
In blood of healthy persons methaemoglobin in minor amounts.
Methaemoglobin concentrations increase during the first 8 hours of nitric oxide exposure.
Overdose with INOmax will be manifest by elevations in methaemoglobin and NO2.
The concentrations of methaemoglobin in the blood should be monitored, see section 4.2.
Acute toxicity is related to anoxia resulting from elevated methaemoglobin levels.
At chronic overdosage increased methaemoglobin levels were measured of which the clinical relevance is controversial.
In vivo, in low concentration, methylthioninium chloride speeds up the conversion of methaemoglobin to haemoglobin.
Methaemoglobin levels> 7% were attained only in patients receiving 80 ppm, where they comprised 35% of the group.
Of the 97 patients treated with INOmax, 2(2%)were withdrawn from study drug due to methaemoglobin levels> 4%.
Methaemoglobin is a protein similar to hemoglobin, from which it differs due to the different state of iron oxidation.
Thus, the end products of nitric oxide that enter the systemic circulation are predominantly methaemoglobin and nitrate.
Methaemoglobin binds with hydrocyanic(senile) acid and other substances, so is used in medicine in such poisoning.
The end medicinal products of nitric oxide that enter the systemic circulation are predominantly methaemoglobin and nitrate.
In adults undergoing heart surgery, methaemoglobin level should be measured within one hour of the initiation of INOmax therapy.
At this level of oxygen saturation, nitric oxide combines predominantly with oxyhaemoglobin to produce methaemoglobin and nitrate.
The patient should be maintained under observation, the methaemoglobin level should be monitored and appropriate supportive measures taken as necessary.
In preterm newborn infants with a gestational age less than 37 weeks as they are at risk of developing increased methaemoglobin levels.
In fact, the iron present in the-EME group of methaemoglobin is oxidized to ferric ion(Fe3+), while in hemoglobin it is found in the form of ferrous ion(Fe2+).
The passage of iron oxidation from a bivalent state to a trivalent state, makes the methaemoglobin incapable of carrying oxygen in our body.
In methaemoglobinaemia, your blood contains too much methaemoglobin(an abnormal form of haemoglobin that is not able to transport oxygen around your body effectively).
Treatment of nitrate poisoning in the hospital includes the neutralization of methaemoglobin, oxygen therapy, the use of cardiac drugs and hepatoprotectors for the liver.
Methaemoglobin formation is related to the cumulative amount of prilocaine percutaneously absorbed, and may therefore increase with prolonged application times of EMLA.
In clinical studies, NO2 levels> 3 ppm or methaemoglobin levels> 7% were treated by reducing the dose of, or discontinuing, INOmax.
The passage of iron oxidation from a bivalent state to a trivalent state, makes the methaemoglobin incapable of carrying oxygen in our body.
Substances known to cause increased methaemoglobin levels should thus be used with caution during therapy with inhaled nitric oxide.
At low oxygen saturation, nitric oxide can combine with deoxyhaemoglobin to transiently form nitrosylhaemoglobin,which is converted to nitrogen oxides and methaemoglobin upon exposure to oxygen.
The average time to reach peak methaemoglobin was 10± 9(SD) hours(median, 8 hours) in these 13 patients; but one patient did not exceed 7% until 40 hours.