Примери за използване на P-gp inducers на Английски и техните преводи на Български
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P-gp inducers.
Strong CYP3A and P-gp inducers.
P-gp inducers.
Interaction with P-gp inducers.
Potent P-gp inducers(e.g. rifampicin, carbamazepine, phenytoin, and St. John's Wort) may decrease exposure to nintedanib.
Use with potent P-gp inducers.
Other P-gp inducers(including but not limited to carbamazepine, phenytoin, and St. John's wort) may decrease talazoparib exposure.
Use with strong P-gp inducers.
No dose adjustment is needed for mirabegron when administered with therapeutic doses of rifampicin orother CYP3A or P-gp inducers.
Use with moderate P-gp inducers.
Concomitant administration of P-gp inducers is expected to result in decreased dabigatran plasma concentrations, and should be avoided(see sections 4.5 and 5.2).
Edoxaban should be used with caution when co-administered with P-gp inducers.
Effects of P-gp inducers on afatinib.
Harvoni is contraindicated with carbamazepine, phenobarbital and phenytoin,potent intestinal P-gp inducers(see section 4.3).
Use with moderate P-gp inducers or moderate CYP inducers. .
Medicinal products that are P-gp inducers(e.g., rifampicin, rifabutin, carbamazepine, phenobarbital or St. John's wort) are expected to decrease plasma concentrations of tenofovir alafenamide, which may lead to loss of therapeutic effect of Vemlidy.
Thus full efficacy of linagliptin in combination with strong P-gp inducers might not be achieved, particularly if these are administered long-term.
Medicinal products that are strong P-gp inducers in the intestine(carbamazepine, phenobarbital, phenytoin, rifampicin and St. John's wort) may significantly decrease sofosbuvir plasma concentration leading to reduced therapeutic effect of Sovaldi and thus are contraindicated with Sovaldi(see section 4.3).
Co-administration of P-gp inhibitors(e.g.,ketoconazole or cyclosporine) or P-gp inducers(e.g., rifampicin) could affect the pharmacokinetics of tigecycline.
Medicinal products that are moderate P-gp inducers in the intestine(e.g. modafinil, oxcarbazepine and rifapentine) may decrease sofosbuvir plasma concentration leading to reduced therapeutic effect of Sovaldi.
Co-administration of P-gp inhibitors(e.g.,ketoconazole or cyclosporine) or P-gp inducers(e.g., rifampicin) could affect the pharmacokinetics of tigecycline(see section 5.2).
Medicinal products that are potent P-gp inducers in the intestine(rifampicin, rifabutin, St. John's wort, carbamazepine, phenobarbital and phenytoin) may significantly decrease sofosbuvir plasma concentration leading to reduced therapeutic effect of Sovaldi and thus are contraindicated with Sovaldi(see section 4.3).
However, the effect of other P-gp inducers on talazoparib exposure has not been studied.
Medicinal products that are strong P-gp inducers(carbamazepine, phenobarbital, phenytoin, rifampicin, rifabutin and St. John's wort) may significantly decrease ledipasvir and sofosbuvir plasma concentrations leading to reduced therapeutic effect of ledipasvir/sofosbuvir and thus are contraindicated with Harvoni(see section 4.3).
Co-administration of rifampicin, rifabutin, and rifapentine,all of which are P-gp inducers, may decrease tenofovir alafenamide plasma concentrations, which may result in loss of therapeutic effect and development of resistance.
Medicinal products that are potent P-gp inducers(rifampicin, rifabutin, St. John's wort, carbamazepine, phenobarbital and phenytoin) may significantly decrease ledipasvir and sofosbuvir plasma concentrations leading to reduced therapeutic effect of ledipasvir/sofosbuvir and thus are contraindicated with Harvoni(see section 4.3).
Co-administration of oxcarbazepine, phenobarbital, or phenytoin,all of which are P-gp inducers, may decrease tenofovir alafenamide plasma concentrations, which may result in loss of therapeutic effect and development of resistance.
Medicinal products that are moderate P-gp inducers in the intestine(e.g. oxcarbazepine) may decrease ledipasvir and sofosbuvir plasma concentrations leading to reduced therapeutic effect of Harvoni.
The concomitant use of edoxaban with other P-gp inducers(e.g. phenytoin, carbamazepine, phenobarbital or St. John's Wort) may lead to reduced edoxaban plasma concentrations.
Medicinal products that are moderate P-gp inducers and/or moderate CYP inducers(e.g. efavirenz, modafinil, oxcarbazepine or rifapentine) may decrease sofosbuvir or velpatasvir plasma concentration leading to reduced therapeutic effect of Epclusa.