Примери за използване на Prolonged half-life на Английски и техните преводи на Български
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Refixia has a prolonged half-life compared to unmodified factor IX.
This process causes the gradual release rate and the prolonged half-life of the steroid.
Due to the prolonged half-life, accelerated elimination with cholestyramine or charcoal may be considered.
Due to the modification of this amazing steroid,gives it a prolonged half-life.
Due to the prolonged half-life, significant serum concentrations may persist for weeks after cessation of therapy.
Binding to hepatic receptors is, however, reduced compared to native t- PA,resulting in a prolonged half-life.
If a repeat dose is required to control the bleed, the prolonged half-life of ALPROLIX should be taken into account(see section 5.2).
Patients with renal impairment Renal impairment is associated with slightly decreased CL/ F and prolonged half-life.
Elderly patients may have a reduced clearance, a prolonged half-life and higher sensitivity to fentanyl than younger patients.
Data from intravenous studies with fentanyl suggest that the elderly patients may have reduced clearance and a prolonged half-life.
Compared to native GLP-1, semaglutide has a prolonged half-life of around 1 week making it suitable for once weekly subcutaneous administration.
Mitotane tissue accumulation: Fat tissue can act as a reservoir for mitotane,resulting in a prolonged half-life and potential accumulation of mitotane.
Caffeine has a prolonged half-life in premature newborn infants and there is potential for accumulation which may necessitate monitoring infants treated for an extended period see section.
Elderly patients Data from intravenous studies with fentanyl suggest that the elderly patients may have reduced clearance and a prolonged half-life.
These engineering features result in a soluble formulation and a prolonged half-life of 4.7 days, which makes it suitable for once-weekly subcutaneous administration.
Measurement of epoetin alfa following multiple dose intravenous administration revealed a half-life of approximately 4 hours in normal volunteers anda somewhat more prolonged half-life in renal failure patients, approximately 5 hours.
When switching from a hypoglycaemic sulphonylurea with a prolonged half-life, a treatment free period of a few days may be necessary to avoid an additive effect of the two products, which might cause hypoglycaemia.
Due to the limited pharmacokinetic data in patients with hepatic impairment,posaconazole should be used with caution in patients with severe hepatic impairment since the prolonged half-life that may occur will lead to increased exposure.
Vyxeos liposomal exhibits a prolonged half-life(%CV) of 31.5 h(28.5%) for daunorubicin and 40.4 h(24.2%) for cytarabine with greater than 99% of the daunorubicin and cytarabine in the plasma remaining encapsulated within the liposomes.
Data from intravenous studies with fentanyl suggest that elderly patients may have reduced clearance, a prolonged half-life, and they may be more sensitive to the drug than younger patients.
However, since decreased clearance of diazepam, with a prolonged half-life have been reported during co-administration of ciprofloxacin and diazepam, and in very rare cases with midazolam, careful monitoring of benzodiazepine therapy is recommended.
Data from intravenous studies with fentanyl suggest that elderly patients may have reduced clearance, a prolonged half-life and they may be more sensitive to the active substance than younger patients.
In patients with severe hepatic impairment, monitoring should be performed every 5 to 7 days until 3 consecutive trough levels have shown stable concentrations of sirolimus after dose adjustment orafter loading dose due to the delay in reaching steady-state because of the prolonged half-life.
In patients with severe hepatic impairment, monitoring should be performed every 5 to 7 days until 3 consecutive trough levels have shown stable concentrations of sirolimus after dose adjustment orafter loading dose due to the delay in reaching steady-state because of the prolonged half-life.
The PK data demonstrate that ELOCTA has a prolonged circulating half-life.
Ritonavir significantly prolonged the half-life of Levitra to 25.7 hours(see section 4.3).
Its half-life is prolonged, and the release of tissue is slow.
In liver failure, the half-life is prolonged, and bioavailability is increased.
Half-life is prolonged if renal function is impaired as shown in table 23.
The half-life was prolonged from 3.7 to 6.0 hours with concurrent ketoconazole administration.