Примери за използване на Rnas на Английски и техните преводи на Български
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There is likely a good reason why genes that make RNAs rather than proteins exist.
The DNA has as main function the storage of the information necessary to construct proteins and RNAs.
For example, we don't know why some guide RNAs work really well and some guide RNAs don't.
Noncoding RNAs are a newly discovered class of molecules that are emerging as a master regulator or facilitator of cancer.
Nematodes that were not able to produce small RNAs in their neurons exhibited defective food identification skills.
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This has revealed that the largest changes occur in genes which regulate how“messenger RNAs” are made.
Short bits of ribonucleic acids(RNAs) prevent the production of the protein from the faulty genes.
What he knew was a sequence of just six nucleotides(6mers)present in small RNAs made them toxic to cancer cells.
We can use these small RNAs directly, introduce them into cells and trigger the kill switch,” said lead author Marcus E.
The researchers then“loaded” the aptamers with large,fluorescent RNAs generating nucleic-acid nanostructures.
The researchers said micro RNAs could be developed as medicines that might prevent, slow or reverse arthritis.
Peter's group found about three percent of all protein-coding large RNAs in the genome can be processed in this way.
Certain RNAs ferry information from DNA to structures(which themselves are largely built of other kinds of RNA) that construct proteins.
This effect was maintained for multiple generations even thoughthe progeny did not have the ability to produce small RNAs themselves.
The paper describing that protein-coding large RNAs can be converted into toxic small RNAs was published Oct. 16 in eLife.
The Lu and Wilkinson teams found that NMD is deficient in IMT,which leads to increased levels of RNAs normally degraded by NMD.
We can use these small RNAs directly, introduce them into cells and trigger the kill switch,” said lead author Marcus E. Peter, the Tomas D.
He did discover, however, that a sequence of just six nucleotides, or 6mers,found in small RNAs made them toxic to cancer cells.
After mice eat, it looks as ifNONO brings all these RNAs together and processes them so they can be used to make proteins," says Panda.
This effect was maintained for multiple generations even thoughthe progeny did not have the ability to produce small RNAs themselves.
But when the researchers restored the ability to produce small RNAs in neurons, the nematodes moved toward food efficiently once again.
Secreted RNAs have already been shown to be involved in cell-cell communication between different tissues/organs and to serve as biomarkers for human disorders, such as cancer.
The researchers believe the results support the hypothesis that small RNAs could help transmit parental environmental information to the next generation.
We found that small RNAs convey information derived from neurons to the progeny and influence a variety of physiological processes, including the food-seeking behavior of the progeny.
Before they arrived at the winning formula consisting of six nucleotides(6mers)present in small RNAs, the researchers tested 4,096 different combinations of nucleotide bases.
They discovered that shards of DNA called enhancer RNAs(eRNAs)- which had previously been considered by scientists to have no functional purpose- contain"instructions" for making molecules that help cancer spread.
Direct repeat sequences and spacers containing complementary sequences[…]could generate complex secondary RNA structures affecting the maturation of CRISPR RNAs in cells," the team writes in their paper.
Specifically, they used small-interfering(si)RNAs to trigger toxicity in cancer cells, a process normally activated by chemotherapy.
RNAs are the direct products of genes, and these small RNAs can bind to other specific mRNA molecules and either increase or decrease their activity, for example by preventing a mRNA from producing a protein.
Scientists are keenly interested in investigating the repertoire of RNAs in motor axons of healthy individuals and ALS patients to gain deeper insight into disease processes.