Примери за използване на Signalling pathways на Английски и техните преводи на Български
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A reduction of both VEGF and bFGF signalling pathways and subsequent angiogenesis/.
Sirtuins are enzymes that regulate the expression of genes that control the function of cells through key cellular signalling pathways.
Cyclin D1 andCDK4/6 are downstream of multiple signalling pathways which lead to cellular proliferation.
These activate signalling pathways from the gut to the brainstem and the hypothalamus to stop food consumption.
The responsible gene is called NLRP12(or NALP12),which has a role in inflammatory signalling pathways.
Inhibition of these signalling pathways can result in cell growth arrest and apoptosis, respectively.
They measured the production of important pro-inflammatory mediators and signalling pathways in the cells after treatment with the extract.
EGFR signalling pathways are involved in the control of cell survival, cell cycle progression, angiogenesis, cell migration and cellular invasion/metastasis.
They analysed the material to determine which genes and signalling pathways were activated as compared to a non-injured lamprey.
Molecular signalling pathways are not unlike a cascade of dominos- when the first domino falls(in this case, the biological molecule activates), it triggers more that trigger more and so on.
PARP enzymes are involved in cellular DNA damage response signalling pathways such as DNA repair, gene transcription, and cell death.
Exenatide has been shown to bind to and activate the known human GLP-1 receptor in vitro,its mechanism of action mediated by cyclic AMP and/or other intracellular signalling pathways.
These kinases are activated upon binding to D-cyclins andplay a crucial role in signalling pathways which lead to cell cycle progression and cellular proliferation.
Baricitinib modulates these signalling pathways by partially inhibiting JAK1 and JAK2 enzymatic activity, thereby reducing the phosphorylation and activation of STATs.
The post will require the culturing of chicken stem cells,development of serum-free culture conditions, and analysis of cell signalling pathways controlling stem cell self-renewal.
New research using human minibrains has revealed that a hallucinogenic compound known as 5-MeO-DMT triggers changes in neuronal signalling pathways associated with inflammation, neural plasticity, and neurodegeneration.
These resultant novel chimeric oncogenic proteins are aberrantly expressed,driving constitutive kinase activity subsequently activating downstream cell signalling pathways involved in cell proliferation and survival leading to TRK fusion-positive cancer.
Idelalisib inhibits phosphatidylinositol 3-kinase p110δ(PI3Kδ), which is hyperactive in B-cell malignancies andis central to multiple signalling pathways that drive proliferation, survival, homing, and retention of malignant cells in lymphoid tissues and bone marrow.
Co-author of the study Dr Daniel Lamport,attributed this improvement to the naturally occurring‘flavonoids' in orange juice that have been proven to improve cognitive ability through the activation of signalling pathways in the hippocampus, a part of the brain that is associated with learning and memory.
These non-clinical studies show that dasatinib can overcome imatinib resistance resulting from BCR-ABL overexpression, BCR-ABL kinase domain mutations,activation of alternate signalling pathways involving the SRC family kinases(LYN, HCK), and multidrug resistance gene overexpression.
The goal is to create accurate real-time models of a system's response to environmental and internal stimuli, such as a model ofa cancer cell in order to find weaknesses in its signalling pathways, or modelling of ion channel mutations to see effects on cardiomyocytes and in turn, the function of a beating heart.
In repeat dose studies in rodents, effects in a variety of tissues(bone, teeth, nail beds, reproductive organs, haematological tissues, kidney and pancreas)appear related to the pharmacology of VEGFR inhibition and/or disruption of VEGF signalling pathways, with most effects occurring at plasma exposure levels below those observed in the clinic.
The biomarker is normally regulated through signaling pathways called EGFR and ERK.
EGFR mutations may lead to constitutive activation of anti-apoptotic and proliferation signaling pathways.
This includes chronic inflammation, DNA damage anddisruption of cell signaling pathways.
Calcium signaling pathways play a vital role in the survival of neurons in the brain.
This includes chronic inflammation, DNA damage anddisruption of cell signaling pathways.
They found that EGCG may hamper the signaling pathways involved in colitis inflammation.
Beside, Pterostilbene does also activate a SIRT1 signaling pathway that protects against cellular damage.
Researchers find the signaling pathway is'main switch' for all scleroderma triggers.