Sta znaci na Engleskom KINAZE - prevod na Енглеском

• kinases
• kinase

Примери коришћења Kinaze на Српском и њихови преводи на Енглески

To je često aktivnost tirozin kinaze.
Often, this is tyrosine kinase activity.

Kinaze se koriste ekstenzivno u prenosu signala i kontroli kompleksnih procesa u ćelijama.
Kinases are used extensively to transmit signals and regulate complex processes in cells.

DAG se takođe može konvertovati u PA posredstvom DAG kinaze.
DAG may also be converted to PA by DAG kinase.

Proteinske kinaze imaju sveobuhvatni i suštinski uticaj na ćelije, i stoga je njihova aktivnost strogo regulisana.
Because protein kinases have profound effects on a cell, their activity is highly regulated.

Za ERK proteine je poznato da aktiviraju mnoge transkripcione faktore, kao što su ELK1, i neke proteinske kinaze.
ERKs are known to activate many transcription factors, such as ELK1, and some downstream protein kinases.

Ova fosfataza može takođe da defosforiliše ciklin-zavisne kinaze, i stoga može da učestvuje u kontroli ćelijskog ciklusa.
This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.

Receptor tirozinske kinaze( RTK) su receptori ćelijske površine visokog-afiniteta za mnoge polipeptidne faktore rasta, citokine, i hormone.
Receptor tyrosine kinases(RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.

Većina kinaza deluje na obe serin i treonin, druge deluju na tirozin, i neke od njih( dualno-specifične kinaze) deluju na sva tri aminokiselinska ostatka.
Most kinases act on both serine and threonine(serine/threonine kinases), others act on tyrosine(tyrosine kinases), and a number act on all three(dual-specificity kinases)..

Fosforilacija ovog proteina posredstvom CDC2 kinaze redukuje DNK helikaznu aktivnost i hromatinsko vezivanje MCM kompleksa.
The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex.

Ove kinaze nastavljaju prenos signala putem fosforilacije prenosioca signala i aktivatora transkripcije( STAT) 1 i 2.
This kinase continues its signal transduction by phosphorylation of signal transducer and activator of transcription(STAT) 1 and 2 via Jak 1 and Tyk2 respectively.

NRP1 je za membranu vezan koreceptor receptora tirozinske kinaze za vaskularni endotelni faktor rasta( VEGF; MIM 192240) i članove familije semaforina( SEMA3A; MIM 603961).
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor(VEGF; MIM 192240) and semaphorin(see SEMA3A; MIM 603961) family members.

Receptor epidermalnog faktora rasta je član ErbB familije receptora, subfamilije sa četiri blisko srodna receptora tirozinske kinaze: EGFR( ErbB-1), HER2/ c-neu( ErbB-2), Her 3( ErbB-3) i Her 4( ErbB-4).
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR(ErbB-1), HER2/neu(ErbB-2), Her 3(ErbB-3) and Her 4(ErbB-4).

Postoje takođe proteinske kinaze koje fosforilišu druge aminokiseline, npr. histidinske kinaze koje fosforilišu histidinski ostatak.
There are also protein kinases that phosphorylate other amino acids, including histidine kinases that phosphorylate histidine residues.

Testovi krvi mogu pokazati povišene nivoe enzima koji učestvuju u mišićnoj i srčanoj aktivnosti( kreatin kinaze) ili povećanje nivoa parametara funkcije bubrega( azot u krvi, kreatinin).
Blood tests may show raised levels of an enzyme that measures the muscle and heart function(creatine kinase) or raised levels of substances that measure kidney function(blood urea nitrogen, creatinine).

Tirozinske kinaze su podgrupa veće klase proteinskih kinaza koje vezuju fosfatne grupe na druge aminokiseline( serin i treonin).
Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids(serine and threonine).

Dok je katalitički domen ovih kinaza veoma konzerviran, niz varijacija koje su primećene u kinomu( podskupu gena u genomu koji kodiraju kinaze) omogućava prepoznavanje različitih supstrata.
While the catalytic domain of these kinases is highly conserved, the sequence variation that is observed in the kinome(the subset of genes in the genome that encode kinases) provides for recognition of distinct substrates.

S818 se fosforiliše posredstvom proteinske kinaze C. Njegova fosforilacija je neophodna za dugotrajnu potencijaciju( LTP; za ulogu GluR1 u LTP, pogledajte ispod).
S818 is phosphorylated by protein kinase C, and is necessary for long-term potentiation(LTP; for GluA1's role in LTP, see below).

Pri aktivaciji, CB1 receptor deluje prvenstveno putem aktivacije Gi, čime se snižava intracelularna cAMP koncentracija putem inhibicije enzima za njegovu produkciju, adenilat ciklaze, i povišava koncentracija mitogenom-aktivirane proteinske kinaze( MAP kinaze).
Upon activation, CB1 receptor exhibits its effects mainly through activation of Gi, which decreases intracellular cAMP concentration by inhibiting its production enzyme, adenylate cyclase, and increases mitogen-activated protein kinase(MAP kinase) concentration.

Mitogenom-aktivirane proteinske kinaze kinaze( MAP2K) je enzim koji fosforiliše mitogenom-aktiviranu proteinsku kinazu( MAPK).
Mitogen-activated protein kinase kinase(also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase(MAPK).

IP3 deluje na IP3 receptore koji su locirani na membrani endoplazmatičnog retikuluma( ER) i pobuđuje oslobađanje Ca2+ iz ER, dok DAG difuzuje duž membrane plazme gde može da aktivira bilo koju formu sekundarne Ser/ Thr kinaze lokalizovane na membrani, takozvane proteinske kinaze C( PKC).
IP3 acts on IP3 receptors found in the membrane of the endoplasmic reticulum(ER) to elicit Ca2+ release from the ER, while DAG diffuses along the plasma membrane where it may activate any membrane localized forms of a second ser/thr kinase called protein kinase C(PKC).

Proteinske kinaze su podložne mutacijama, usled čega mogu da budu zamrznute u uključenoj poziciji, i da uzrokuju neregulisani rast ćelije, što je neophodno za razvoj kancera.
Protein kinases can become mutated, stuck in the"on" position, and cause unregulated growth of the cell, which is a necessary step for the development of cancer.

Dodatni proteini kao što su koaktivatori, remodelatori hromatina, histonske acetilaze, deacetilaze, kinaze, i metilaze, koji takođe učestvuju u regulaciji gena, nemaju DNK-vezujuće domene, i stoga nisu transkripcioni faktori.
Other proteins such as coactivators, chromatin remodelers, histone acetyltransferases, histone deacetylases, kinases, and methylases are also essential to gene regulation, but lack DNA-binding domains, and therefore are not TFs.

Za receptor tirozinske kinaze je bilo pokazano da su ne samo ključni regulatori normalnih ćelijskih procesa, nego i da imaju kritičnu ulogu u razvoju i progresiji mnogih tipova raka.
Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer.

Razni estri forbola imaju značajna biološka svojstva, kao što je sposobnost da deluju kao tumorni promoteri putem aktivacije proteinske kinaze C. Oni oponašaju diacilglicerole, glicerolne derivate kod kojih su dve hidroksilne grupe reagovale sa masnim kiselinama da formiraju estre.
Various esters of phorbol have important biological properties, the most notable of which is the capacity to act as tumor promoters through activation of protein kinase C. They mimic diacylglycerols, glycerol derivatives in which two hydroxyl groups have reacted with fatty acids to form esters.

Dok sve serin/ treonin kinaze fosforilišu serin ili treonin ostatake u svojim supstratima, one biraju specifične ostataka na osnovu ostataka koji okružuju mesto fosfoakceptora, koji zajedno čine konsenzus sekvencu.
While serine/threonine kinases all phosphorylate serine or threonine residues in their substrates, they select specific residues to phosphorylate on the basis of residues that flank the phosphoacceptor site, which together comprise the consensus sequence.

Aktivirani receptor se spreže sa Gq/ 11, aktivira fosfolipazu C i povišava koncentraciju citosolnog Ca2+, čime se zatim inicira ćelijski respons kao što je stimulacija proteinske kinaze C. Aktivirani receptor takođe inhibira adenilat ciklazu i razne tirozinske kinaze.
The activated receptor in turn couples to Gq/11 and Gi/o and thus activates phospholipase C and increases the cytosolic Ca2+ concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. Activated receptor also inhibits adenylate cyclase and activates various tyrosine kinases.

Takođe je prisutan receptor tirozinske kinaze, proteina MuSK, signalni protein uključen u razvoj neuromišićnog spoja, koja se takođe održava u mestu pri rapsinu.
Also present is the receptor tyrosine kinase protein MuSK, a signaling protein involved in the development of the neuromuscular junction, which is also held in place by rapsyn.

Abnormalni kanabidiol( abn-cbd) je sintetički regioizomer kanabidiola, koji za razliku od većine drugih kanabinoida proizvodi vazodilatorne efekte, snižava krvni pritisak, i podstiče ćelijsku migracija, ćelijsku proliferaciju i aktivira mitogenom-aktivirane proteinske kinaze kod mikroglija, ali ne proizvodi psihoaktivne efekte.
Abnormal cannabidiol(Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects.

Termin,„ ekstracelularnim signalom regulisane kinaze", se ponekad koristi kao sinonim za mitogenom-aktivirane proteinske kinaze( MAPK), ali je u skorije vreme bio usvojen za specifičniji podskup sisarske MAPK familije.
The term,"extracellular signal-regulated kinases", is sometimes used as a synonym for mitogen-activated protein kinase(MAPK), but has more recently been adopted for a specific subset of the mammalian MAPK family.

Posledično, ako se dva inhibitora proteinske kinaze vezuju za aktivna mesta sa sličnim afinitetom- a samo jedan od njih treba da se nadmeće sa ATP molekulima, onda će kompetitivni inhibitor na mestu proteinskog vezivanja efektivnije inhibirati enzim.
As a consequence, if two protein kinase inhibitors both bind in the active site with similar affinity, but only one has to compete with ATP, then the competitive inhibitor at the protein-binding site will inhibit the enzyme more effectively.