Using lentiviral vectors to replace mutated genes in blood stem cells, scientists successfully treat two rare diseases apparently without causing harmful side effects.
FLT3在造血细胞和祖细胞的细胞膜上,并参与血细胞的增殖和分化。
FLT3 is expressed on the cell membranes of hematopoietic cells and progenitor cells, and is involved in the differentiation and proliferation of blood cells.
脐带血是造血干细胞(HSC)的丰富来源,主要负责补充血液和促进免疫系统再生。
Cord blood is a rich source of Haematopoietic Stem Cells(HSCs), which are primarily responsible for replenishing blood and regenerating the immune system.
异基因造血干细胞移植:可以大大提升治疗效果,主要用于有合适提供者的年轻患者。
Allogeneic hematopoietic stem cell transplantation: can greatly improve the treatment effect and is mainly used to young patients who have suitable providers.
这些造血干细胞非常稀有,分裂缓慢,而且同时具有自我更新和分化成其他各种类型血细胞的能力。
These blood stem cells were rare, slow to divide, and capable of both self-renewal and differentiation into any of the blood's more specialized cell types.
UM171是一种造血干细胞自我更新激动剂,已显示可在小鼠中扩增脐带血干细胞并增强多谱系血细胞重构。
UM171, a haematopoietic stem cell self-renewal agonist, has been shown to expand cord blood stem cells and enhance multilineage blood cell reconstitution in mice.
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