Ví dụ về việc sử dụng Sulbactam trong Tiếng anh và bản dịch của chúng sang Tiếng việt
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How should I use ampicillin and sulbactam?
Cefoperazone/sulbactam is a combination drug used as an antibiotic.
It contains esterified ampicillin and sulbactam.
The combination cefoperazone/sulbactam(Sulperazon) is available in many countries.[3].
Actively active substance: ampicillin sodium, sodium sulbactam.
Ampicillin/sulbactam is a combination of a β-lactam antibiotic and a β-lactamase inhibitor.
Cefoperazone is also sold as a co-formulation with sulbactam.
Sulbactam is able to inhibit the most common forms of β-lactamase but is not able to interact with the AmpC cephalosporinase.
Sultamicillin is a mutual prodrug of ampicillin and sulbactam.
Ampicillin and sulbactam are both hydrophilic antibiotics and have a volume of distribution(Vd) similar to the volume of extra-cellular body water.
The main active ingredients of the powder are ampicillin and sulbactam.
There is no data on the presence of any pharmacokinetic interaction between sulbactam and cefoperazone with the introduction of cefoperazone/ sulbactam.
Sulbactam is a β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.
Vials of 3.0 g containing 2 g Ampicillin(as sodium salt)and 1 g Sulbactam(as sodium salt).
However, when ampicillin is given in combination with sulbactam, regrowth of bacteria has been seen when sulbactam levels fall below certain concentrations.
Vials of 1.5 g containing 1.0 gAmpicillin(as sodium salt) and 500 mg Sulbactam(as sodium salt);
Bone and Joint infections Ampicillin/sulbactam can be used in the treatment of bone and joint infections caused by susceptible beta-lactamase producing bacteria.[ 8][ 9][ 10][ 11].
It has a molecular weight of 371.39 grams andits chemical formula is C16H18N3NaO4S.[1] Sulbactam sodium is also a derivative of 6-aminopenicillanic acid.
The activity of sulbactam against Acinetobacter spp. seen in in-vitro studies makes it distinctive compared to other β-lactamase inhibitors, such as tazobactam and clavulanic acid.[3].
The double ester ofampicillin readily disintegrates under the influence of beta-lactamases, and sulbactam irreversibly inhibits a group of bacterial enzymes aimed at combating antibiotics of the penicillin series.
Ampicillin-sulbactam only comes in a parenteral formulation to be either used as intravenous or intramuscular injections, and can be formulated for intravenous infusion.[1][13]It is formulated in a 2:1 ratio of ampicillin: sulbactam.
In the second case,a powder containing ampicillin in the amount of 500 mg and sulbactam weighing 250 mg comes complete with water for the preparation of injections(1.8 ml).
Gynecological Infections Ampicillin/sulbactam can be used to treat gynecological infections caused by beta-lactamase producing strains of Escherichia coli, and Bacteroides(including B. fragilis).[1][7].
It is effective for the treatment of urinary tract infections.[2] It contains cefoperazone,a β-lactam antibiotic, and sulbactam, a β-lactamase inhibitor, which helps prevent bacteria from breaking down cefoperazone.[3].
The recommended adult dose of ampicillin/sulbactam is 1.5 grams(1g ampicillin sodium plus 0.5g sulbactam sodium) to 3.0 grams(2g ampicillin sodium plus 1g sulbactam sodium) every six hours.
Cefoperazone exerts its bactericidal effect byinhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms.
Intra-abdominal infections Ampicillin/sulbactam can be used to treat intra-abdominal infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella(including K. pneumonia), Bacteroides fragilis, and Enterobacter.[1][2].
In the second case,a powder containing ampicillin in the amount of 500 mg and sulbactam weighing 250 mg comes complete with water for the preparation of injections(1.8 ml). At the same time, Ampisid is packaged in vials and the solvent in ampoules.