Primeri uporabe Decrease in cmax v Angleški in njihovi prevodi v Slovenski
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There is a 49% decrease in Cmax of nateglinide in dialysis-dependent diabetic patients.
The rate of absorption was affected, resulting in a 36% decrease in Cmax and an increase in Tmax by 2 hours.
There was a decrease in Cmax and AUC, and an increase in the time to reach maximum plasma concentrations when amifampridine phosphate was administered with food as compared to without food.
Administration of TMZ with food resulted in a 33% decrease in Cmax and a 9% decrease in area under the curve(AUC).
Indinavir A pharmacokinetic study with indinavir has shown a 28% decrease in AUC anda 36% decrease in Cmax for indinavir.
Administration of TMZ with food resulted in a 33% decrease in Cmax and a 9% decrease in area under the curve(AUC).
Erythromycin: Concomitant use of Sinlip and erythromycin resulted in a 20% decrease in AUC(C-t)and 30% decrease in Cmax of Rosuvastatin.
Mg dose of imatinib resulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment.
Concomitant use of Crestor and erythromycin resulted in a 20% decrease in AUC(0-t) and a 30% decrease in Cmax of rosuvastatin.
Less than 20% decrease in AUC and 10% decrease in Cmax were observed in patients with mild and moderate hepatic impairment(Child-Pugh Class A and B).
Ingestion of vorapaxar with a high-fat mealresulted in no meaningful change in AUC with a small(21%) decrease in Cmax and delayed tmax(45 minutes).
The rate isdecreased when given with food resulting in a decrease in Cmax by approximately 25-30% and a delay in tmax to approximately 2.5 hours.
Total exposure and half-life of azithromycin were unchanged by the coadministration of fluconazole, however,a clinically insignificant decrease in Cmax(18%) of azithromycin was observed.
However, there is a delay in the rate of absorption characterised by a decrease in Cmax and a delay in time to peak plasma concentration(tmax).
Co-administration with a high-fat and high-calorie meal in healthy volunteers reduces the extent of absorption, resulting in an approximately 20% decrease in area under the concentration versus time curve(AUC)and 50% decrease in Cmax in plasma.
The rate and extent of absorption is reduced whenriluzole is administered with high-fat meals(decrease in Cmax of 44%, decrease in AUC of 17%).
Administration of rosiglitazone with food resulted in no change in overall exposure(AUC),although a small decrease in Cmax(approximately 20-28%) and a delay in tmax(approximately 1.75 h) were observed compared to dosing in the fasted state.
Antacids Concomitant ingestion of an antacid containing magnesium hydroxide and aluminium hydroxide has been shown to delay absorption of febuxostat(approximately 1 hour)and to cause a 32% decrease in Cmax, but no significant change in AUC was observed.
Pretreatment with multiple doses of rifampicin 600 mg followed by a single400 mg dose of imatinib resulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment.
The rate and extent of absorption of metformin from Eucreas 50 mg/1000 mg weredecreased when given with food as reflected by the decrease in Cmax by 26%, AUC by 7% and delayed Tmax(2.0 to 4.0 h).
Administration of rosiglitazone with food resulted in no change in overall exposure(AUC),although a small decrease in Cmax(approximately 20% to 28%) and a delay in tmax(ca.1.75 h) were observed compared to dosing in the fasting state.
Against the background of strong CYP3A4 inducer rifampicin(300 mg 2 times a day for 9 days) in healthy female volunteers,a marked decrease in Cmax and AUC figures ulipristala and its active metabolite by over 90%.
Administration of voriconazole did not have a significant effect on mean Cmax and AUCτ of ritonavir in the high dosestudy, although a minor decrease in steady state Cmax and AUCτ of ritonavir with an average of 25% and 13% respectively was observed in the low dose ritonavir interaction study.
Decrease in MPA Cmax and AUC(0-12h) by 30% and 25%, respectively, were observed when CellCept was concomitantly administered with sevelamer without any clinical consequences(i.e. graft rejection).