Examples of using Decrease in cmax in English and their translations into Bulgarian
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Medicine
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Ecclesiastic
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Ecclesiastic
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For abacavir there was a decrease in Cmax with 23% and AUC was unchanged.
A pharmacokinetic study with indinavir has shown a 28% decrease in AUC and a 36% decrease in Cmax for indinavir.
There is a 49% decrease in Cmax of nateglinide in dialysis-dependent diabetic patients.
The rate of absorption was affected, resulting in a 36% decrease in Cmax and an increase in Tmax by 2 hours.
There was a decrease in Cmax and AUC, and an increase in the time to reach maximum plasma concentrations when amifampridine phosphate was administered with food as compared to without food.
Food intake led to a decreased exposure by up to 14%, a decrease in Cmax by up to 18% and delayed tmax by 0.5 hours.
Administration of TMZ with food resulted in a 33% decrease in Cmax and a 9% decrease in area under the curve(AUC).
Administration of TMZ with food resulted in a 33% decrease in Cmax and a 9% decrease in area under the curve(AUC).
Antacids Concomitant ingestion of an antacid containing magnesium hydroxide and aluminium hydroxide has been shown to delay absorption of febuxostat(approximately 1 hour) andto cause a 32% decrease in Cmax, but no significant change in AUC was observed.
Less than 20% decrease in AUC and 10% decrease in Cmax were observed in patients with mild and moderate hepatic impairment(Child-Pugh Class A and B).
Administration of a high fat meal resulted in a 1.9% increase in AUC0-last, 28% decrease in Cmax, and 12% decrease in C24 hr.
According to Desjardins et al(2015)1,there was 60% decrease in Cmax for a diclofenac acid capsule, compared to a 43% decrease in Cmax for a potassium tablet, in the fed state vs fasted.
The rate and extent of absorption is reduced when riluzole is administered with high-fat meals(decrease in Cmax of 44%, decrease in AUC of 17%).
AUC was comparable while there was a small decrease in Cmax of lixisenatide of 22-34% compared with separate simultaneous administration of insulin glargine and lixisenatide, which is not likely to be clinically significant.
Administration of a low fat meal with raltegravir 1,200 mg once daily resulted in a 42% decrease in AUC0-last, 52% decrease in Cmax, and 16% decrease in C24hr.
Although there is a 49% decrease in Cmax of nateglinide in dialysis patients, the systemic availability and half-life in diabetic subjects with moderate to severe renal insufficiency(creatinine clearance 15-50 ml/min) was comparable between renal subjects requiring haemodialysis and healthy subjects.
However, there is a delay in the rate of absorption characterised by a decrease in Cmax and a delay in time to peak plasma concentration(tmax).
Co-administration with a high-fat and high-calorie meal in healthy volunteers reduces the extent of absorption, resulting in an approximately 20% decrease in area under the concentration versus time curve(AUC)and 50% decrease in Cmax in plasma.
The rate of pregabalin absorption is decreased when given with food resulting in a decrease in Cmax by approximately 25-30% and a delay in tmax to approximately 2.5 hours.
Although there is a 49% decrease in Cmax of nateglinide in dialysis patients, the systemic availability and half-life in diabetic subjects with moderate to severe renal insufficiency(creatinine clearance 15-50 ml/min) was comparable between renal subjects requiring haemodialysis and healthy subjects.
Ingestion of vorapaxar with a high-fat meal resulted in no meaningful change in AUC with a small(21%) decrease in Cmax and delayed tmax(45 minutes).
When given with a high-fat meal,the rate of absorption of imatinib was minimally reduced(11% decrease in Cmax and prolongation of tmax by 1.5 h), with a small reduction in AUC(7.4%) compared to fasting conditions.
Administration of 0.5 mg entecavir with a standard high-fat meal(945 kcal, 54.6 g fat) or a light meal(379 kcal, 8.2 g fat)resulted in a minimal delay in absorption(1-1.5 hour fed vs. 0.75 hour fasted), a decrease in Cmax of 44-46%, and a decrease in AUC of 18-20%.
Administration of rosiglitazone with food resulted in no change in overall exposure(AUC),although a small decrease in Cmax(approximately 20-28%) and a delay in tmax(approximately 1.75 h) were observed compared to dosing in the fasting state.
The rate and extent of absorption of metformin from Zomarist 50 mg/1000 mg were decreased when given with food as reflected by the decrease in Cmax by 26%, AUC by 7% and delayed Tmax(2.0 to 4.0 h).
Administration of rosiglitazone with food resulted in no change in overall exposure(AUC),although a small decrease in Cmax(approximately 20-28%) and a delay in tmax(approximately 1.75 h) were.
The rate and extent of absorption of metformin from Eucreas 50 mg/1000 mg were decreased when given with food as reflected by the decrease in Cmax by 26%, AUC by 7% and delayed Tmax(2.0 to 4.0 h).
Pretreatment with multiple doses of rifampicin 600 mg followed by a single 400 mg dose of imatinib resulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment.