Sta Znaci INTEGRASE na Hrvatskom - Hrvatski Prijevod

• integraze
• integrazi

Primjeri korištenja Integrase na Engleski i njihovi prijevodi na Hrvatskom

Integrase Strand Transfer Inhibitors.
Inhibitori prijenosa niza transferaze.

Hiv antiviral agents: integrase inhibitors.
Hiv antivirusni lijekovi: inhibitori integraze.

HIV-1 integrase inhibitor(e.g. raltegravir);
HIV-1 inhibitori integraza(npr. raltegravir);

Hiv antiviral agents: integrase inhibitors.
Antivursni lijekovi za hiv: inhibitori integraze.

The virus produces an enzyme called HIV integrase.
Virus proizvodi enzim koji se naziva HIV integraza.

Hiv antiviral agents: integrase strand transfer inhibitors.
Antivirotici za liječenje infekcije hiv-om: inihibitori prijenosa lanca integraze.

Integrase is an HIV-1 encoded enzyme that is required for viral replication.
Integraza je HIV-1 kodirani enzim koji je potreban za replikaciju virusa.

DUTREBIS also helps stop the production of an enzyme called“HIV integrase”.
DUTREBIS također pomaže zaustaviti stvaranje enzima koji se zove"HIV integraza.

It blocks an enzyme called integrase, which is involved in a step in the reproduction of HIV.
Inhibira enzim naziva integraza koji je uključen u koraku reprodukcije HIV-a.

Patients were either given the Triumeq combination or a different three-drug combination(Atripla) that did not include an integrase inhibitor.
Bolesnici su primali ili kombinaciju lijeka Triumeq ili različitu kombinaciju od tri lijeka(Atripla) koja nije uključivala inhibitor integraze.

It blocks an enzyme called integrase that is needed for the subsequent stage of virus replication.
Inhibira enzim naziva integraza koji je potreban za naredne faze umnožavanja virusa.

The dose depends on whether the infection is known or suspected to be resistant to medicines of the class to which Tivicay belongs integrase inhibitors.
Doza ovisi o tome je li poznato ili se sumnja da je infekcija otporna na lijekove klase, u koju se ubraja Tivicay inhibitori integraze.

Inhibition of integrase prevents the covalent insertion, or integration, of the HIV genome into the host cell genome.
Inhibicija integraze sprječava kovalentno umetanje, odnosno integraciju, genoma HIV-a u genom stanice domaćina.

Patients with prior treatment failure that included an integrase inhibitor and integrase class resistance.
Bolesnici s neuspješnim odgovorom na prethodno liječenje koje je uključivalo inhibitor integraze i rezistencija na skupinu inhibitora integraze.

Additional integrase mutations observed in cell culture selection included H51Y, F121Y, S147G, S153Y, E157Q, and R263K.
Dodatne mutacije integraze zapažene u izdvojenoj staničnoj kulturi bile su H51Y, F121Y, S147G, S153Y, E157Q i R263K.

This is an antiviral medicine that blocks an enzyme called integrase that is needed by the HIV virus to make new copies of itself in the body.
To je antivirusni lijek koji blokira enzim zvan integraza koja je potrebna kako bi se virus HIV-a kopirao u nove kopije u tijelu.

The second study involved 833 patients given either a combination of Tivicay with two NRTIs or a different three-drug combination(Atripla) that did not include an integrase inhibitor.
Drugo ispitivanje obuhvatilo je 833 bolesnika koji su primili kombinaciju lijeka Tivicay s dva NRTI-a ili kombinaciju tri različita lijeka(Atripla) koja nije uključivala inhibitor integraze.

In subtype C(n=2) and A/G(n=2) isolates the integrase substitution R263K was selected in one isolate, and G118R in two isolates.
U izolatima podvrste C(n=2) i A/G(n=2), supstitucija R263 na integrazi izdvojena je u jednom izolatu, a supstitucija G118R u dvama izolatima.

With the exception of Y143C/R/H, HIV-1 with the primary raltegravir-associated substitutions T66K, Q148H/K/R, or N155H in integrase is associated with reduced susceptibility to elvitegravir.
Uz iznimku Y143/C/R/H, HIV-1 s primarnim supstitucijama povezanih s raltegravirom, T66K, Q148H/K/R ili N155H u integrazi povezan je sa smanjenom osjetljivošću na elvitegravir.

In the presence of integrase inhibitor resistance, there are insufficient data to recommend a dose for Tivicay in children and adolescents.
U slučaju rezistencije na inhibitore integraze, nema dovoljno podataka za preporuku doze lijeka Tivicay u djece i adolescenata.

In this study, Vitekta was at least as effective as raltegravir(another integrase inhibitor) when taken in combination with other anti-HIV medicines.
U ovom ispitivanju lijek Vitekta bio je barem jednako učinkovit kao raltegravir(drugi inhibitor integraze) ako se uzima zajedno s drugim lijekom protiv HIV-a.

Other substitutions in integrase that occurred in addition to a primary INSTI resistance substitution each in single cases were H51Y, L68V, G140C, S153A, E157Q, and G163R.
Ostale supstitucije u integrazi koje su nastale pored primarne supstitucije rezistencije na INSTI u svakom pojedinačnom slučaju bile su H51Y, L68V, G140C, S153A, E157Q i G163R.

The most common substitutions that emerged in HIV-1 isolates from elvitegravir-treated subjects were T66I/A(n 8), E92Q/G(n 7), T97A(n 4), S147G(n 4), Q148R(n 4), and N155H(n 5) in integrase.
Najčešće supstitucije koje su nastale u izolatima HIV-1 u ispitanika liječenih elvitegravirom bile su T66I/A(n 4), E92Q/G(n 7), T97A(n 4), S147G(n 4), Q148R(n 4) i N155H(n 5) u integrazi.

Cross-resistance between nevirapine and either HIV protease inhibitors, HIV integrase inhibitors or HIV entry inhibitors is unlikely because the enzyme targets involved are different.
Ukrižena rezistencija na nevirapin i inhibitore proteaza HIV-a, inhibitore integraza HIV-a ili inhibitore ulaska HIV-a nije vjerojatna budući da ti lijekovi djeluju na različite enzime.

SVR rates were> 94% across combination antiretroviral therapy(cART) regimens, including boosted-PI-, NNRTI-, and integrase inhibitor(INSTI)-based therapies.
Stope SVR-a bile su> 94% uz sve režime kombinirane antiretrovirusne terapije, uključujući terapije utemeljene na pojačanom inhibitoru proteaze, nenukleozidnom inhibitoru reverzne transkriptaze(NNRTI) i inhibitoru integraze INSTI.

Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral Deoxyribonucleic acid(DNA) integration which is essential for the HIV replication cycle.
Dolutegravir inhibira HIV integrazu vezanjem za aktivno mjesto integraze i blokiranjem koraka prijenosa lanca u sklopu integracije retrovirusne deoksiribonukleinske kiseline(DNK), koji je ključan za ciklus replikacije HIV-a.

The first of these involved 715 patients whose previous treatment had not included an integrase inhibitor and whose infection was therefore not expected to be resistant to this class of medicines.
Prvo od ova dva ispitivanja uključilo je 715 bolesnika čije prethodno liječenje nije uključivalo inhibitor integraze, te se stoga za njihovu infekciju nije moglo očekivati da će biti otporna na ovu klasu lijekova.

Lamivudine has been widely used as a component of antiretroviral combination therapy with other antiretroviral agents of the same class(NRTIs) or different classes PIs, non-nucleoside reverse transcriptase inhibitors, integrase inhibitors.
Lamivudin se široko primjenjuje kao dio kombinirane antiretrovirusne terapije zajedno s drugim antiretrovirusnim lijekovima iste skupine(NRTI) ili drugih skupina IP, nenukleozidni inhibitori reverzne transkriptaze, inhibitori integraze.

Since the recommended dose of dolutegravir is 50 mg twice daily for patients with resistance to integrase inhibitors, the use of Triumeq is not recommended for patients with integrase inhibitor resistance.
Budući da preporučena doza dolutegravira za bolesnike s rezistencijom na inhibitore integraze iznosi 50 mg dvaput na dan, primjena lijeka Triumeq ne preporučuje se u bolesnika s rezistencijom na inhibitore integraze.

An integrase inhibitor- dolutegravir Tivicay also available in pill"Triumeq"(a combination with abacavir and lamivudine), raltegravir(Isentress) or elvitegravircobicistat(Vitekta and Tybost also available in tablet Stribild combination with tenofovir and emtricitabine);
Integraza inhibitora- dolutegravir Tivicay također dostupan u pilulu"Triumeq"(kombinacija s abakavir i lamivudin), raltegravira(Isentress) ili elvitegravircobicistat(Vitekta i Tybost također dostupan u tabletama Stribild kombinaciji s tenofovir i emtricitabina);