Exemplos de uso de Cholera toxin em Inglês e suas traduções para o Português
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Recombinant cholera toxin B subunit(rCTB) 1 mg.
Vibrio cholerae" is a non-toxic strain that can become toxic,producing cholera toxin, when it is infected with the phage CTXφ.
The cholera toxin has a total molecular weight of about 85.2 KDa.
The vaccine contains killed whole V.cholerae O1 bacteria and the recombinant non-toxic B-subunit of the cholera toxin CTB.
The cholera toxin(CT) is a protein that belongs to the family of type AB toxins. .
Dukoral contains small amounts of inactivated(killed)cholera bacteria and a part of the cholera toxin called the‘B subunit.
Recombinant cholera toxin B subunit(rCTB) 1 mg.*bacterial content prior to inactivation.
The other two studies compared Dukoral(containing recombinant cholera toxin) with placebo in over 22,000 people in Peru.
The intracellular target of cholera toxin is the adenyl cyclase, one of the most important systems of regulation of eukaryotic cells.
Mechanism of action The vaccine contains killed whole V.cholerae O1 bacteria and the recombinant non-toxic B-subunit of the cholera toxin CTB.
In this study, Dukoral was made using cholera toxin extracted from cholera bacteria in place of the newer recombinant toxin. .
Cholera toxin is a protein secreted by the bacterium Vibrio cholerae and responsible for the main symptom of cholera, an acute diarrhoea.
WC-rBS(marketed as"Dukoral") is a monovalent inactivated vaccine containing killed whole cells ofV. cholerae O1 plus additional recombinant cholera toxin B subunit.
The anti-toxin intestinal antibodies prevent the cholera toxin from binding to the intestinal mucosal surface, thereby preventing the toxin-mediated diarrhoeal symptoms.
Inaba classical biotype(heat inactivated), Inaba El Tor biotype(formalin inactivated), Ogawa classical biotype(heat inactivated),Ogawa classical biotype(formalin inactivated).- Recombinant cholera toxin B subunit(rCTB) 1 mg.
Trophic effects on enterocytes===The hypersecretion of water and electrolytes(including chloride ions),caused by cholera toxin during a"Vibrio cholerae" infection, can be reduced significantly with the introduction of"S. boulardii.
The cholera toxin is encoded by a transcription unit, containing the CtxA gene that encodes the subunit A and the CtxB gene that encodes the subunit B, present in the genome of the CTXΦ(CTXphi) phage.
The aim of this study was to describe and to compare cytoarchitectural and neurochemical features of the md of the rock cavy and the marmoset(callithrix jacchus) by imunohistochemical techniques to reveal neroactive substances, as well as to map the retinal projection for this nucleus using an anterograde tracer,the b subunit of cholera toxin ctb.
The anti-toxin intestinal antibodies prevent the cholera toxin from binding to the intestinal mucosal surface thereby preventing the toxin-mediated diarrhoeal symptoms.
With less evidence than the previous drugs mentioned, but cited as useful, we have sulfasalazine, methotrexate, penicillin, minocycline, indomethacin, etretinate, cyclophosphamide, chlorambucil, plamaferese, prostaglandin E1, intravenous human immunoglobulin, anti-tumor necrosis factor-alpha, levamisole,peptide linked to cholera toxin, granulocyte and monocyte apheresis, and anti-CD52.
In Dukoral, the cholera toxin is produced by a method known as‘ recombinant DNA technology': it is made by a bacterium that has received a gene(DNA), which makes it able to produce the toxin. .
Other strategies that may avoid potential non-specific effects of pharmacological inhibitors involve co-localization of transported cargo with these determinants using fluorescence or radioisotope labeling,utilization of specific ligands as controls(e.g. transferrin or cholera toxin B, as indicated above), and siRNA to knockdown the expression of regulatory elements of these pathways.
Fusion proteins composed by a genetically modified cholera toxin subunit A1, peptides from the acetylcholine receptor alpha chain and a dimer of the D fragment from Staphylococcus aureus protein A.
The cholera toxin catalyzes the transfer of ADP-ribose from NAD(Nicotinamide Adenine Dinucleotide) to a specific arginine residue in Gs proteina, resulting in the activation of adenyl cyclase and consequently in the increase of intracellular cAMP level.
The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily.
Concept of Cholera Toxin The existence of a toxin responsible for cholera symptoms was proposed in 1884 by Robert Koch, who suspected that the agent responsible for cholera produced"a special poison" that acted on the intestinal epithelium and that the cholera symptoms could be"considered as poisoning.