Examples of using Accelerated phase in English and their translations into Danish
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Accelerated phase CML at 400 mg twice daily.
Adult patients with accelerated phase disease were enrolled.
The recommended dosage of Glivec is 600 mg/ day for patients in accelerated phase.
Chronic, accelerated phase and blast crisis.
Tasigna is used in the‘ chronic' and‘ accelerated' phases of CML.
Paediatric accelerated phase CML and blast.
Major cytogenetic response, haematological response, molecular response(evaluation of minimal residual disease),time to accelerated phase or blast crisis and survival are main secondary endpoints.
In the study of accelerated phase CML, 50(42%) of the 119 patients had a haematological response, after having received Tasigna for an average of 202 days around seven months.
The second study included a total of 119 patients whose disease was in the‘ accelerated phase', four fifths of whom had stopped responding to imatinib.
The primary efficacy variable was the rate of haematological response, reported as either complete haematological response, no evidence of leukaemia, orreturn to chronic phase CML using the same criteria as for the study in accelerated phase.
Progression was defined as any of the following events:progression to accelerated phase or blast crisis, death, loss of CHR or MCyR, or in patients not achieving a CHR an increasing WBC despite.
However, the occurrence of these cytopenias is likely to be related to the stage of the disease being treated andthey were more frequent in patients with accelerated phase CML or blast crisis as compared to patients with.
Accelerated phase is defined by the presence of any of the following: blasts≥ 15% but< 30% in blood or bone marrow, blasts plus promyelocytes≥ 30% in blood or bone marrow(providing< 30% blasts), peripheral blood basophils≥ 20%, platelets< 100 x 109/ l unrelated to therapy.
Treatment was discontinued for adverse reactions in 11% of patients in chronic phase CML,12% in accelerated phase CML, 15% in myeloid blast phase CML, and 8% in lymphoid blast phase CML or Ph+ ALL.
In clinical trials in CML, drug discontinuation for drug-related adverse reactions was observed in 2.4% of newly diagnosed patients, 4% of patients in late chronic phase after failure of interferon therapy,4% of patients in accelerated phase after failure of interferon therapy and 5% of blast crisis patients after failure of interferon therapy.
The Committee decided that Tasigna' s benefits are greater than its risks for the treatment of adults with chronic phase and accelerated phase Philadelphia chromosome positive CML with resistance or intolerance to prior therapy including imatinib.
Three large, international, open-label, non-controlled phase II studies were conducted in patients with Philadelphia chromosome positive(Ph+)CML in advanced, blast or accelerated phase disease, other Ph+ leukaemias or with CML in the chronic phase but failing prior interferon-alpha(IFN) therapy.
Let me now turn to the proposal for the accelerated phasing in of double-hull oil tankers.
The scenarios were based on an accelerated phasing in of electric vehicles for passenger transport, increased blending percentages in biofuels for all vehicles, and the introduction of biogas primarily for heavy transport, relative to a situation without new national biogas initiatives.