Examples of using Decrease in AUC in English and their translations into Portuguese
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Administration of fruit juice with aliskiren resulted in a decrease in AUC and Cmax of aliskiren.
A 29% and 56% decrease in AUC and Cmax compared to tablet was reported when rivaroxaban granulate is released in the proximal small intestine.
Grapefruit juice: Administration of grapefruit juice with aliskiren resulted in a decrease in AUC and Cmax of aliskiren.
For zidovudine(200 mg every 8 hours) a 25% decrease in AUC was reported when combined with ritonavir 300 mg every 6 hours.
Co-administration of pioglitazone with rifampicin(an inducer of cytochrome P450 2C8)is reported to result in a 54% decrease in AUC of pioglitazone.
The decrease in AUC, Cmax, and Cmin was not mitigated when an increased dose of REYATAZ/ritonavir(400/100 mg once daily) was temporally separated from omeprazole by 12 hours.
Indinavir A pharmacokinetic study with indinavir has shown a 28% decrease in AUC and a 36% decrease in Cmax for indinavir.
The rate and extent of absorption is reduced when riluzole is administered with high-fat meals decrease in Cmax of 44%, decrease in AUC of 17.
Concomitant use of Crestor and erythromycin resulted in a 20% decrease in AUC(0-t) and a 30% decrease in Cmax of rosuvastatin.
The apparent total body clearance at steady state(CL/F)increased with age over the 3-month period with a corresponding decrease in AUC.
Less than 20% decrease in AUC and 10% decrease in Cmax were observed in patients with mild and moderate hepatic impairment Child-Pugh Class A and B.
Co-administration of pioglitazone with rifampicin(aninducer of cytochrome P450 2C8) is reported to result in a 54% decrease in AUC for pioglitazone.
Administration of dabrafenib 150 mg twice daily and warfarin resulted in a decrease in AUC of S- and R- warfarin and of 37% and 33% compared to administration of warfarin alone.
Repeated administration of rifampin(600 mg once daily),a strong CYP3A inducer, resulted in an increase in cabazitaxel clearance of 21% corresponding to a decrease in AUC of 17.
Although a slight decrease in AUC was observed in patients with Child-Pugh C hepatic insufficiency, the decrease was within the range of population estimates noted for healthy subjects.
Following administration of a dose of 850 mg,a 40% lower plasma peak concentration, a 25% decrease in AUC and a 35 min prolongation of time to peak plasma concentration was observed.
Co-administration of omeprazole(40 mg once daily) with atazanavir 300 mg/ritonavir 100 mg to healthy volunteers resulted in a substantial reduction in atazanavir exposure approximately 75% decrease in AUC, Cmax and Cmin.
Following administration of a dose of 850 mg,a 40% lower plasma peak concentration, a 25% decrease in AUC and a 35 min prolongation of time to peak plasma concentration was observed.
The decrease in AUC, Cmax, and Cmin was not mitigated when an increased dose of REYATAZ/ ritonavir(400/ 100 mg once daily) was temporally separated from omeprazole by 12 hours.
Administration of empagliflozin/metformin 12.5 mg/1,000 mg under fed conditions resulted in 9% decrease in AUC and a 28% decrease in Cmax for empagliflozin, when compared to fasted conditions.
When a single dose of 20 mg vortioxetine was co-administered following 10 days of rifampicin 600 mg/day(a broad inducer of CYP isozymes)in healthy subjects, a 72% decrease in AUC of vortioxetine was observed.
A small decrease in trametinib bioavailability,corresponding to a decrease in AUC of 12%, was estimated when trametinib is administered in combination with dabrafenib, a CYP3A4 inducer, using a population PK analysis.
Following administration of a dose of 850 mg, a 40% lower plasma peak concentration,a 25% decrease in AUC(area under the curve) and a 35 minute prolongation of the time to peak plasma concentration were observed.
In this study, administration of the chewable tablet with a high fat meal led to an average 6% decrease in AUC, 62% decrease in Cmax, and 188% increase in C12hr compared to administration in the fasted state.
Results from a clinical study demonstrated a change in sonidegib exposure(32% and 38% decrease in AUC and Cmax) after co-administration of a single dose of Odomzo 200 mg with esomeprazole(a proton pump inhibitor) at 40 mg daily for 6 days in healthy subjects.
Decreases in AUC(27%) and Cmax(50%), and an increase in tmax(173%) in whole blood were evident.
Rifampicin is a strong CYP3A4 inducer andhas been shown to cause a 72% decrease in atazanavir AUC which can result in virological failure and resistance development.
Co- administration of orange orapple juice with aliskiren 150 mg resulted in a 62% decrease in aliskiren AUC or in a 63% decrease in aliskiren AUC, respectively.
Co-administration of nelfinavir 1250 mg BID with methadone 80+/- 21 mg once a day in HIV negative methadone maintenance patients resulted in a 47% decrease in methadone AUC.
Co- administration of grapefruit juice with aliskiren 150 mg resulted in a 61% decrease in aliskiren AUC and co-administration with aliskiren 300 mg resulted in a 38% decrease in aliskiren AUC. .