Examples of using Initial loading dose in English and their translations into Portuguese
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The recommended initial loading dose is 8 mg/kg body weight.
Part A was a 6-week, randomised, double-blind,placebo-controlled period to evaluate rilonacept at a dose of 160 mg weekly after an initial loading dose of 320 mg.
The recommended initial loading dose of Herceptin is 4 mg/kg body weight.
Although a great variability is observed in the premature population,peak plasma concentrations are measured around 35-40 mg/l after the initial loading dose of 10 mg/kg as well as after the last maintenance dose, whatever gestational and postnatal age.
This initial loading dose is based on body weight and on the pretreatment antithrombin activity level.
As a three-weekly regimen the recommended initial loading dose of Herceptin is 8 mg/kg body weight.
If the initial loading dose was well tolerated, the subsequent doses can be administered as a 30-minute infusion.
In this study, Dex was administered at an intraoperative initial loading dose of 6 µg/kg/h, followed by an infusion at 0.4 µg/kg/h.
As a weekly regimen(initial loading dose of 4 mg/kg followed by 2 mg/kg every week) concomitantly with paclitaxel following chemotherapy with doxorubicin and cyclophosphamide.
This drug should be introduced immediately after the diagnosis in all patients, at an initial loading dose of 162 to 325mg, followed by a daily maintenance dose of 100mg, indefinitely.
The recommended initial loading dose of RIXUBIS was to ensure that during surgery, factor IX activity levels of 80-100% for major surgeries and 30-60% for minor surgeries were maintained.
Patients assigned to receive Herceptin were given an initial loading dose of 8 mg/ kg, followed by 6 mg/ kg every three weeks for one year.
Initial loading dose of 8 mg/ kg body weight, followed by 6 mg/ kg body weight 3 weeks later and then 6 mg/ kg repeated at 3-weekly intervals administered as infusions over approximately 90 minutes.
The recommended initial loading dose of Perjeta is 840 mg administered as a 60 minute intravenous infusion, followed every 3 weeks thereafter by a maintenance dose of 420 mg administered over a period of 30 to 60 minutes.
Patients assigned to receive Herceptin were given an initial loading dose of 8 mg/kg, followed by 6 mg/kg every three weeks for either one or two years.
When administered with Perjeta the recommended initial loading dose of trastuzumab is 8 mg/kg body weight administered as an intravenous infusion followed every 3 weeks thereafter by a maintenance dose of 6 mg/kg body weight.
If the time between two sequential infusions is 6 weeks or more, the initial loading dose of 840 mg Perjeta should be re-administered as a 60-minute intravenous infusion followed every 3 weeks thereafter by a maintenance dose of 420 mg administered over a period of 30 to 60 minutes.
In the adjuvant setting,Herceptin has also been investigated as a weekly regimen(an initial loading dose of 4 mg/ kg followed by 2 mg/ kg every week for one year) concomitantly with paclitaxel(administered weekly(80 mg/ m2) or every 3 weeks(175 mg/ m2) for a total of 12 weeks) following 4 cycles of AC doxorubicin 60 mg/ m2 IV push concurrently with cyclophosphamide 600 mg/ m2 over 20- 30 minutes.
In a study of 276 ACS patients managed with PCI,switching from an initial loading dose of 600 mg clopidogrel or placebo administered upon presentation to the hospital prior to coronary angiography to a 60 mg loading dose of prasugrel administered at the time of percutaneous coronary intervention, resulted in a similar increased inhibition of platelet aggregation for the 72 hour duration of the study.
Patients need to receive an initial higher dose(loading dose) on the first day.
An initial 70 mg loading dose should be administered on Day-1.
When used to treat fungal infections,patients need to receive an initial higher dose(loading dose) on the first day.
In patients weighing more than 80 kg, after the initial 70 mg loading dose, caspofungin 70 mg daily is recommended see section 5.2.
The PIEB pump in group B was programmed to deliver 10 mL of 0.1% Ropivacaine plus Sufentanil 0.2 µg/mL solution every hour beginning 60 min after the administration of the initial epidural loading dose.
If a loading dose is indicated, an initial dose of 100 mg followed by a 50 mg twice daily regimen for the first week should be used.
Initial Therapy(2 to 3 months post-transplant): In most patients receiving Rapamune tablets with a loading dose of 6 mg followed by an initial maintenance dose of 2 mg, whole blood sirolimus trough concentrations rapidly achieved steady-state concentrations within the recommended target range 4 to 12 ng/mL, chromatographic assay.
Initial settings were for administration of a loading dose of 0.4 mg, a lockout interval of 10 minutes, and PCA dose 0.2 mg. If analgesia was inadequate after 1 hour, the bolus dose was increased to 0.4 mg by the PCA team, all of which was blinded to the treatment arm.
In most patients receiving Rapamune tablets with a loading dose of 6 mg followed by an initial maintenance dose of 2 mg, whole blood sirolimus trough concentrations rapidly achieved steady-state concentrations within the recommended target range 4 to 12 ng/ ml, chromatographic assay.