Examples of using Cuscc in English and their translations into Romanian
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Colloquial
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Official
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Medicine
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Ecclesiastic
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Ecclesiastic
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Computer
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Programming
It has not been determined whether cuSCC is related to Odomzo treatment.
Cases of cuSCC have been reported in patients treated with vemurafenib.
Patients with advanced BCC have an increased risk of developing cuSCC.
It has not been determined whether cuSCC is related to Erivedge treatment.
Cases of cuSCC have been reported in advanced BCC patients treated with Erivedge.
Monitoring for skin lesions should occur as described for cuSCC.
Cases of cuSCC have been reported in advanced BCC patients treated with Odomzo.
The prescriber should examine the patient monthly during and up to six months after treatment for cuSCC.
CuSCC was very commonly reported and was most commonly treated by local excision.
Therefore, all patients should be monitored routinely while taking Erivedge, and cuSCC should be treated according to the standard of care.
Cases of cuSCC can be managed with excision and do not require treatment modification.
Older patients(≥ 65 years) may be more likelyto experience adverse reactions, including cuSCC, decreased appetite, and cardiac disorders.
The incidence of cuSCC in vemurafenib-treated patients across studies was approximately 20%.
Therefore, all patients should be monitored routinely while taking Odomzo, and cuSCC should be treated according to the standard of care.
In patients who develop cuSCC, it is recommended to continue the treatment without dose adjustment.
Dose modifications are not recommended for adverse reactions of cutaneous squamous cell carcinoma(cuSCC) or new primary melanoma(see dabrafenib SmPC for further details).
CuSCC usually occurred early in the course of treatment with a median time to the first appearance of 7 to 8 weeks.
Ninety-six percent of patients on dabrafenib monotherapy in the integrated safety population andall patients on combination therapy in the Phase III studies who developed cuSCC continued on treatment without dose modification.
Cases of cuSCC(including keratoacanthoma) have been reported in patients treated with trametinib in combination with dabrafenib.
Of the patients who experienced cuSCC, approximately 33% experienced> 1 occurrence with median time between occurrences of 6 weeks.
In the Phase III study MEK115306, cuSCC occurred in 3%(6/209) of patients receiving trametinib in combination with dabrafenib and 10%(22/211) of patients receiving dabrafenib as a single agent.
In the Phase III study MEK116513, cuSCC occurred in 1%(5/350) of patients receiving trametinib in combination with dabrafenib and 18%(63/349) of patients receiving vemurafenib as a single agent.