Examples of using Phosphorylated in English and their translations into Russian
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Colloquial
RNase H leaves a 5'-phosphorylated product.
When not phosphorylated, DAF-16 is active and present in the nucleus.
Muscle cells use CreatinePhosphate, a phosphorylated form of Creatine, to store energy.
Phosphorylated H2AX(also known as γ-H2AX) is a marker for DNA double strand breaks.
NBS1 relocates to DSB sites by interaction of FHA/BRCT domains with phosphorylated histone H2AX.
The complex produced consists of EJC, UPF3,UPF2, phosphorylated UPF1 and SMG1 and in turn triggers degradation of the mRNA.
Passive immunization with specific antibodies IgG2a/k pS404 resulted in the reduction of plaque deposition and phosphorylated of tau protein 40.
This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
In order for Cdc20 to bind the APC/C,specific APC/C subunits must be phosphorylated by Cdk1 among other Cdks.
Once phosphorylated, E2F activates the transcription of cyclins E and A. Active cyclin E-cdk begins to accumulate and completes pRb phosphorylation.
It cleaves the 3'-end of unpaired C and U residues,ultimately forming a 3'-phosphorylated product via a 2', 3'-cyclic monophosphate intermediate.
Phosphorylated NADH(NADPH) has the same spectral properties as non-phosphorylated NADH, though it is not involved in energy metabolism reactions directly.
This means that FDG is trapped in any cell that takes it up until it decays, since phosphorylated sugars, due to their ionic charge, cannot exit from the cell.
Arrestin linking: The phosphorylated receptor can be linked to arrestin molecules that prevent it from binding(and activating) G proteins, in effect switching it off for a short period of time.
Since there was established a considerable correlation between progressing dementia and the levels of phosphorylated tau protein, further development of treatment methods based on anti-tau immunization is of great interest.
Phosphorylated ephexin1 can then activate the small GTPase, RhoA, leading to subsequent activation of its effector, Rho-kinase(ROCK), which results in the rearrangement of actin filaments.
This tracer is a glucose analog that is taken up by glucose-using cells and phosphorylated by hexokinase whose mitochondrial form is greatly elevated in rapidly growing malignant tumors.
The phosphorylated serine and threonine residues act as binding sites for arrestin proteins that prevent the reassociation of the G proteins with their receptors, thereby preventing reactivation of the signaling pathway.
The end repair treatment converts any damaged or incompatible protruding ends of DNA to 5'-phosphorylated and blunt-ended DNA, enabling immediate blunt-end ligation, while the A-tailing treatment adds an A to the 3' end of the sheared DNA.
NS5A has two phosphorylated forms: p56 and p58, which differ in the electrophoretic mobility. p56 is basally phosphorylated by host cellular protein kinase at the center and near the C terminus, whereas p58 is a form of hyperphorylated NS5A at the center of the serine-rich region.
In patients with this pathology, signs of TGF-β activity are observed in the form of elevated accumulation of nuclear phosphorylated SMAD2 and concentration increase of connective tissue growth factor, which is induced by TGF-β 10, 109.
F-FDG is taken up by cells, phosphorylated by hexokinase(whose mitochondrial form is greatly elevated in rapidly growing malignant tumours), and retained by tissues with high metabolic activity, such as most types of malignant tumours.
Conceptualization and diagnosis of these entities has been evolving from clinical-pathological phenotypes, which could not be resolved until autopsy, to new research diagnostic criteria thatincorporate molecular biomarkers(for example, amyloid-beta(Aβ) and phosphorylated tau), and in vivo structural, functional, and perfusion imaging.
We would like to know how many proteins needs to be phosphorylated how much to bring about this state of affairs, and have been trying to enumerate the mitotic targets for various cyclin-CDK combinations for some time.
These findings combined with the cis-regulatory element analysis allowed to draw the following conclusions: а Nova cis-elements localized within downstream intron are enhancers, whereas localized within exon and upstream intron are splicing silencers; b Nova and Fox factors co-regulate about 100 exons; c Nova executes two-level regulation of protein-protein interactions involved in synaptic contacts: splicing regulation of kinases and phosphatases(25 and 9, respectively) andalso splicing regulation of the exons encoding phosphorylated protein sites 75.
Once within cells,glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate, which then enters glycolysis or is polymerized into glycogen.
Of note, the level of histone H2A expression, phosphorylated by serin residue in position 139(Ser139)(pH2AX), which is a well-known marker of double-strand DNA breaks, increased significantly in GIST T-1 cells after the exposure to chemotherapeutic agents indicated above Figure 5 a.
GSK-3 is responsible for phosphorylating(and thus deactivating) glycogen synthase.
These dimers phosphorylate each other and enhance catalytic activity of the kinase.
Aurora B also phosphorylates myosin II regulatory light chain at the cleavage furrow.