Examples of using Reverse mutation in English and their translations into Slovak
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Crizotinib was not mutagenic in vitro in the bacterial reverse mutation(Ames) assay.
Latanoprost was found negative in reverse mutation tests in bacteria, gene mutation in mouse lymphoma and mouse micronucleus test.
Eribulin was not mutagenic in vitro in the bacterial reverse mutation assay(Ames test).
In an in vitro bacterial reverse mutation assay(Ames test), increases in the number of revertant colonies were observed in 2 of the 5 strains exposed to florbetapir.
Eribulin mesylate wasnot mutagenic in in vitro bacterial reverse mutation assays(Ames test).
Trametinib was not genotoxic in studies evaluating reverse mutations in bacteria, chromosomal aberrations in mammalian cells and micronuclei in the bone marrow of rats.
Cabazitaxel did not induce mutations in the bacterial reverse mutation(Ames) test.
Carfilzomib was not mutagenic in the in vitro bacterial reverse mutation(Ames) test and was not clastogenic in the in vivo mouse bone marrow micronucleus assay.
The combination of emtricitabine andtenofovir disoproxil fumarate was negative in the bacterial reverse mutation assay(Ames assay).
Ferric citrate was neither mutagenic in the bacterial reverse mutation assay(Ames test) nor clastogenic in the chromosomal aberration test in Chinese hamster fibroblasts.
These studies tested for dozens of adverse effects, including endotoxicity, cytotoxicity,genotoxicity, reverse mutation, chromosomal aberration, and acute toxicity.
Trifluridine was shown to be genotoxic in a reverse mutation test in bacteria, a chromosomal aberration test in mammal-cultured cells, and a micronucleus test in mice.
Rilpivirine has tested negative in the absence and presence of a metabolicactivation system in the in vitro Ames reverse mutation assay and the in vitro clastogenicity mouse lymphoma assay.
A bacterial reverse mutation assay study(“Ames test”) was performed with the cysteamine bitartrate used for PROCYSBI and cysteamine bitartrate did not show any mutagenic effects in this test.
Peginterferon beta-1a was not mutagenicwhen tested in an in vitro bacterial reverse mutation(Ames) test and was not clastogenic in an in vitro assay in human lymphocytes.
No mutagenic response was elicited by cidofovir at dose levels up to 5 mg/plate, in the presence and absence of metabolic activation by rat liver S-9 fraction, in microbial assays involving Salmonella typhimurium for base pair substitutions or frameshift mutations(Ames)and Escherichia coli for reverse mutations.
Maraviroc was not mutagenic or genotoxic in a battery of in vitro andin vivo assays including bacterial reverse mutation, chromosome aberrations in human lymphocytes and rat bone marrow micronucleus.
Sirolimus was not mutagenic in the in vitro bacterial reverse mutation assays, the Chinese Hamster Ovary cell chromosomal aberration assay, the mouse lymphoma cell forward mutation assay, or the in vivo mouse micronucleus assay.
Darunavir was not mutagenic or genotoxic in a battery of in vitro andin vivo assays including bacterial reverse mutation(Ames), chromosomal aberration in human lymphocytes and in vivo micronucleus test in mice.
Temsirolimus was not genotoxic in a battery of in vitro(bacterial reverse mutation in Salmonella typhimurium and Escherichia coli, forward mutation in mouse lymphoma cells, and chromosome aberrations in Chinese hamster ovary cells) and in vivo(mouse micronucleus) assays.
Lopinavir/ ritonavir was not found to be mutagenic or clastogenic in a battery of in vitro andin vivo assays including the Ames bacterial reverse mutation assay, the mouse lymphoma assay, the mouse micronucleus test and chromosomal aberration assays in human lymphocytes.
Bazedoxifene was not genotoxic or mutagenic in a battery of tests,including in vitro bacterial reverse mutation assay, in vitro mammalian cell forward mutation assay at the thymidine kinase(TK/-) locus in L5178Y mouse lymphoma cells, in vitro chromosome aberration assay in Chinese hamster ovary(CHO) cells, and in vivo mouse micronucleus assay.
Ritonavir was not found to be mutagenic or clastogenic in a battery of in vitro andin vivo assays including the Ames bacterial reverse mutation assay using S. typhimurium and E. coli, the mouse lymphoma assay, the mouse micronucleus test and chromosomal aberration assays in human lymphocytes.
Genotoxicity studies demonstratedthat clofarabine was not mutagenic in the bacterial reverse mutation assay, but did induce clastogenic effects in the non-activated chromosomal aberration assay in Chinese Hamster Ovary(CHO) cells and in the in vivo rat micronucleus assay.
In genotoxicity studies with other recombinant growth hormone preparations,there was no evidence of gene mutation in bacterial reverse mutation assays, chromosomal damage in human lymphocyte and mouse bone marrow cells, gene conversion in yeast or unscheduled DNA synthesis in human carcinoma cells.
Bazedoxifene was not genotoxicor mutagenic in a battery of tests, including in vitro bacterial reverse mutation assay, in vitro mammalian cell forward mutation assay at the thymidine kinase(TK±) locus in L5178Y mouse lymphoma cells, in vitro chromosome aberration assay in Chinese hamster ovary(CHO) cells, and in vivo mouse micronucleus assay.
Naltrexone was negative in the following in vitro genotoxicitystudies: bacterial reverse mutation assay(Ames test), the heritable translocation assay, CHO cell sister chromatid exchange assay, and the mouse lymphoma gene mutation assay.
Tedizolid phosphate was negative for genotoxicity in all in vitro assays(bacterial reverse mutation[Ames], Chinese hamster lung[CHL] cell chromosomal aberration) and in all in vivo tests(mouse bone marrow micronucleus, rat liver unscheduled DNA synthesis).
CRISPR applications are far-ranging-from identifying genes associated with cancer and rare diseases to reversing mutations that cause blindness.