Examples of using Metformin has in English and their translations into Swedish
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Metformin has been available in the EU since the 1950s.
In humans, independently of its action on glycaemia, metformin has favourable effects on lipid metabolism.
Long term treatment of metformin has been associated with a decrease of vitamin B12 absorption with decrease of serum levels.
In humans, independently of its action on glycaemia, metformin has favourable effects on lipid metabolism.
Metformin has a much better safety profile,
In humans, independently of its action on glycaemia, metformin has favourable effects on lipid metabolism.
Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption
Bioequivalence of Glubrava with co-administered pioglitazone and metformin has also been demonstrated see section 5.2.
Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption, which may very rarely result in clinically significant vitamin B12 deficiency e.g., megaloblastic anaemia.
However, bioequivalence of Eucreas with co-administered vildagliptin and metformin has been demonstrated see section 5.2.
Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption which may very rarely result in clinically significant vitamin B12 deficiency e.g. megaloblastic anaemia.
Vildagliptin on its own was approved by the EU in September 2007 under the name Galvus, and metformin has been available in the EU since 1959.
In other studies, vildagliptin in combination with metformin has been shown to be more effective than placebo when used with a sulphonylurea or insulin.
There have been no therapeutic clinical trials conducted with Janumet tablets however bioequivalence of Janumet with co-administered sitagliptin and metformin has been demonstrated(see section 5.2).
Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption which may very rarely result in clinically significant vitamin B12 deficiency(e.g., megaloblastic anaemia).
in combination with metformin has been evaluated in over 6800 patients with type 2 diabetes mellitus.
Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption(table 3)
There have been no therapeutic clinical trials conducted with Komboglyze tablets, however, bioequivalence of Komboglyze with co-administered saxagliptin and metformin has been demonstrated see section 5.2.
The co-administration of alogliptin and metformin has been studied as dual therapy in patients initially treated with metformin alone, and as add-on therapy to a thiazolidinedione or insulin.
The co-administration of canagliflozin and metformin has been studied in patients with type 2 diabetes inadequately controlled on metformin either alone or in combination with other glucose-lowering medicinal products.
The efficacy of nateglinide in combination with metformin has been compared to the combination of gliclazide
The coadministration of dapagliflozin and metformin has been studied in subjects with type 2 diabetes inadequately controlled on metformin alone
The co-administration of saxagliptin and metformin has been studied in patients with type 2 diabetes inadequately controlled on metformin alone
The CHMP concluded that the combination of linagliptin and metformin has been shown to be effective at lowering HbA1c levels,
Reported cases of lactic acidosis in patients on metformin have occurred primarily in diabetic patients with impaired renal failure or acute worsening of renal function.
Saxagliptin and metformin have a negligible influence on the ability to drive
The benefits of canagliflozin used in combination with metformin have been shown in several main studies that were evaluated at the time of the authorisation of Invokana.
Studies in animals performed with vildagliptin and metformin have not shown evidence of teratogenicity,
The CHMP considered that adding alogliptin to existing treatment with pioglitazone with or without metformin had shown to produce modest
Some patients taking metformin have experienced the following side effects after starting sitagliptin.