Examples of using Pregabalin in English and their translations into Vietnamese
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Pregabalin treatment can be started with a dose of 150 mg per day.
The product information for gabapentin and pregabalin contain warnings about cases of abuse and dependence.
Pregabalin steady-state pharmacokinetics are similar in healthy volunteers, patients with epilepsy receiving anti-epileptic medicinal products and patients with chronic pain.
Exceeding this level can lead to severe Pregabalin side effects, which will be hard or costly to reverse.
All Pregabalin forms work in the same way, and your doctor will be the best person to choose the right one for you depending on your condition or what you want to achieve by the end of the dosage cycle.
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The effects of pregabalin appear after 1 week of use and is similar in effectiveness to lorazepam, alprazolam, and venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms.
Doctors may prescribe gabapentin(Neurontin®), pregabalin(Lyrica®) or another anticonvulsant to help control burning and pain.
In all but one case of attempted suicide andthree cases of suicidal thoughts, pregabalin was the sole suspected drug.
Gabapentin and pregabalin for pain- is increased prescribing a cause for concern?
Certain anti-seizure medications, including gabapentin(Gralise, Horizant, Neurontin) and pregabalin(Lyrica), can lessen the pain of postherpetic neuralgia.
Neuropathic pain: Pregabalin treatment can be started at a dose of 150 mg per day.
A small number of adults and children 5 years of age and older(about 1 in 500 people)who took anticonvulsants such as pregabalin to treat various conditions during clinical studies became suicidal during their treatment.
At this point, the Pregabalin dosage can be stretched to a maximum of 300mg per day, but that should be done with time.
There is a risk that you may experience changes in your mentalhealth if you take an anticonvulsant medication such as pregabalin, but there may also be a risk that you will experience changes in your mental health if your condition is not treated.
In trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did require less morphine and had fewer opioid-related side effects.
In 2016,the ASA released a promising study with the combination of dextromethorphan with pregabalin, acetaminophen, and naproxen which showed a decrease in postoperative pain intensity(preemptive analgesia).[12].
The good news is that all these Pregabalin side effects can be controlled if you inform your doctor in time although some conditions will disappear with time when you experience the advanced effects mentioned above don't continue taking the dosage without informing your medic.
Evidence from other animal models of nerve damage andpersistent pain suggest the anti-nociceptive activities of pregabalin may also be mediated through interactions with descending noradrenergic and serotonergic pathways originating from the brainstem that modulate pain transmission in the spinal cord.
Pregabalin is a GABA analogue that is a 3-substituted derivative as well as a γ-amino acid.[74][2] Specifically, pregabalin is S 3-isobutyl-GABA.[75][76][77] Pregabalin also closely resembles the α-amino acids L-leucine and L-isoleucine, and this may be of greater relevance in relation to its pharmacodynamics than its structural similarity to GABA.
In recent years, the FDA has approved pregabalin(Lyrica), duloxetine(Cymbalta) and milnacipran(Savella) for the treatment of fibromyalgia.
Pregabalin is generally not regarded as efficacious in the treatment of acute pain.[25][needs update] In trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did require less morphine and had fewer opioid-related side effects.[2][32] Several possible mechanisms for pain improvement have been discussed.[33].
In other parts of the world, like in Europe, Pregabalin is used in the treatment of anxiety disorder, a condition that other medications are used to treat in the United States of America.
Although the mechanism of action of pregabalin has not been fully elucidated, results with genetically modified mice and with compounds structurally related to pregabalin(such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive and antiseizure effects in animals.
Since the first approved the drug in 2004,millions of patients have benefited from Pregabalin especially in managing nerve pains resulting from various diseases such as Epilepsy, Post-herpetic neuralgia or pains that occur after shingles, Diabetic neuropathy pain and Fibromyalgia.
There were also reports of the negative effects of pregabalin on the activity of the gastrointestinal tract(including the development of paralytic ileus, intestinal obstruction, constipation) when used together with drugs that cause constipation(such as non-narcotic analgesics).
The World Federation of Biological Psychiatry recommends pregabalin as one of several first line agents for the treatment of generalized anxiety disorder, but recommends other agents such as SSRIs as first line treatment for obsessive-compulsive disorder and post-traumatic stress disorder.