Examples of using Telithromycin in English and their translations into Vietnamese
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Telithromycin- the first and only approved ketolide.
Prolonged QTc intervals may also be caused by telithromycin.[2].
Telithromycin- the first and only approved ketolide Cethromycin Solithromycin.
During active phagocytosis, large concentrations of telithromycin is released.
Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin.
Azithromycin- unique;does not extensively inhibit CYP3A4 Clarithromycin Erythromycin Fidaxomicin Telithromycin.
Telithromycin prevents bacteria from growing, by interfering with their protein synthesis.
The only previously marketed ketolide, telithromycin, suffers from rare but serious side effects.
Telithromycin was approved by the European Commission in July 2001 and subsequently went on sale in October 2001.
Also bactericidal are daptomycin, fluoroquinolones, metronidazole, nitrofurantoin,co-trimoxazole, telithromycin.
Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek.
Like many other protein synthesis inhibitors, telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.
Telithromycin binds to the subunit 50S of the bacterial ribosome,[7] and blocks the progression of the growing polypeptide chain.
The concentration of verapamil in the blood can be increased by clarithromycin,erythromycin, telithromycin, and antiviral drugs for treating HIV infection.
In the US, telithromycin received U.S. Food and Drug Administration(FDA) approval on April 1, 2004.
French pharmaceutical company Hoechst Marion Roussel(later Sanofi-Aventis)began phase II/III clinical trials of telithromycin(HMR-3647) in 1998.
Telithromycin is metabolized mainly in the liver, the main elimination route being the bile, a small portion is also excreted into the urine.
Dapoxetine should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole,ritonavir, and telithromycin.
Telithromycin must not be taken by people taking any of the following medicines, because the combination may result in an increased risk of serious side effects.
Recent studies[16] have shown this to belikely due to the presence of the pyridine-imidazole group of the telithromycin side chain acting as an antagonist towards various nicotinic acetylcholine receptors.
In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain.
In the United States, the FDA's Office of Epidemiology and Surveillance identified 12 cases of acute liver failure, resulting in four deaths, and an additional 23 cases of acute, serious liver injury,among 5.2 million patients taking telithromycin through April 2006.[4][5].
Some types of antibiotics such as clarithromycin, telithromycin, erythromycin(several brand names exist, please contact your healthcare provider to determine if you are taking this medicine).
Solithromycin differs from telithromycin because the side chain does not significantly antagonize nicotinic acetylcholine receptors.[17] Instead of the pyridine-imidazole group used on telithromycin, this molecule has a triazole-phenylamine moiety.
In July 2006, according to the New York Times, unpublished e-mails from FDAsafety official David Graham argued telithromycin had not been proven safe, that safer drugs were available for the same indications, and that the approval was a mistake and should be immediately withdrawn.[13].
The concentration of telithromycin in the tissues is much higher than in plasma. Telithromycin fulfills a role that has arisen due to the rise of microbial resistance to existing macrolides and appears to be effective against macrolide-resistant Streptococcus pneumoniae.
The study showed that a pyridine moiety that is part of the telithromycin molecule acts as an antagonist on cholinergic receptors located in the neuromuscular junction, the ciliary ganglion of the eye and the vagus nerve innervating the liver.