CD4 and CD6 biomarkers and nodal microenvironment, February 2010, p. 3-6.
ウイルスサイズのスマートナノマシンが、体内の微小環境を自律巡回し、24時間治療・診断を行います。
Smart nanomachines of a virus size will autonomously patrol the microenvironments in the body and provide diagnostic and therapeutic services 24 hours a day.
High tumor microenvironment expression of CD7 and dietary lifestyle factors in fNHL patients linked to increased survival time, December 2012 Newsletter, p. 8-10.
多発性骨髄腫治療におけるマルチカラー・フローサイトメトリーの有用性~MRD・微小環境の変動~。
Utility of multicolor flow cytometry for treatment of multiple myeloma-MRD measurement and fluctuation of microenvironment-.
近年、がんの転移と再発の双方を支持する微小環境(転移ニッチ)の概念が提唱されている。
In recent years, metastatic niches, which are microenvironments that support both metastasis and relapse of cancer, are proposed.
さらに、腫瘍細胞はまた、微小環境およびその先への相互作用をも修正する。
In addition the tumor cells also modify the interaction with the microenvironment and beyond.
Spread throughout it are small reservoirs of stem cells,nested within supportive microenvironments called niches, which keep a tight rein on this repair process.
These findings reveal that multiplecell types contribute to the immunosuppressive tumor microenvironment and will inform therapeutic cancer vaccine design.
Understanding the crosstalk between acinar cells with Kras mutations and the microenvironment of those cells is key to developing targeted strategies to prevent and treat this cancer,” he says.
We should be able to be dealing with these things at this level, and these conclusions say that growth and malignant behavior is regulated at the level of tissue organization andthat the tissue organization is dependent on the extracellular matrix and the microenvironment.
Massimiliano Mazzone(VIB-KU Leuven):“To fully understand all the ins and outs of these processes,we also need to take a closer look at the tumor microenvironment and the immune system.
And it was recently shown experimentally that restoring themetabolic balance in the tumor microenvironment-- that is, making sure immune cells get their food-- can give them, the predators, back their edge in fighting cancer.
Basically, patients who were receiving the treatment had no TGF-beta in their samples,” Dr. Gulley said, noting that the drug appeared to be trapping the protein andremoving it from the tumor microenvironment.
We further postulate that the same mechanisms by which hyaluronan regulates stem cell quiescence and differentiation in stem cell niches may block progenitor cell differentiation andmaturation in the microenvironments of CNS lesions, thus preventing the repair of the CNS.
The developed nanomachine contrast agent detects the microscopic environment of cancer tissue and has a previously unknown feature of amplifying MRI signal strength. The research team has shown that it makes possible tumor-specific imaging superior to existing MRI contrast agents.
We aim to realize a"In-Body Hospitals", which provides necessary diagnosis and treatment inside the required parts of the body at the precise time, by creating"smart nanomachines the size of a virus size,which autonomously patrol the microenvironments in the body". This has been mere science fiction until now, but will be made a reality by self-organization of macromolecules integrated with functionals elements required for pin-point diagnosis and targeted therapy.
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