Changes in the quantity orthe conformation of tau protein could affect its function as a microtubules stabilizer and some of the processes wherein it is involved.
Two other molecular motors called the kinesin and dynein motors transport various intracellularsubstances over a long distance by their translatory movements on microtubule rails in the cells.
Encounters between individual motor proteins and tau on microtubules were observed directly, which revealed dramatic differences between the effects of tau on the motility of two microtubule-based motors, dynein versus kinesin.
The use of microtubule targeting agents(MTAs) for treatment of multiple tumour types is very common but their effectiveness is often hampared due to drug resistance.
微小管の量子情報は破壊されません、それは破壊されることができません、宇宙に放出して宇宙に消えます。
The quantum information in microtubules is not destroyed, it can not be destroyed; it is simply distributed and dispelled by the universe.”.
Our combined experiments using STED super-resolution microscopy andgenerating Camsap3 gene knockouts has allowed us to analyze microtubule alignment in epithelial cells in greater detail than ever before," explains Takeichi.
As a result, they found that the dynein motor has two long stalks protruding from the AAA+ ring, which is the site for ATP hydrolysis,and that the dynein motor moves on microtubules while changing the structure of its two stalks.
She added:“Recent research in the neurology field has reported that axons[nerve fibres] in women's brains are a lot thinner andthey have fewer microtubules[hollow tubes that give shape to cells].
Unlike that which is possible with larger gold(usually 20-40 nm), even dense accumulations of 5-nm gold, e.g.,on structures such as microtubules, are not visible in the light microscope.
微小管関連。
Microtubule Organization.
エリブリンは、新規の作用機序を有するハリコンドリン系の微小管ダイナミクス阻害剤です。
Eribulin is a halichondrin class microtubule dynamics inhibitor with a novel mechanism of action.
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