Примери за използване на Based on in vitro на Английски и техните преводи на Български
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Based on in vitro data.
Artenimol and piperaquine were not genotoxic/clastogenic based on in vitro and in vivo testing.
Based on in vitro data, alectinib is not a substrate of P-gp.
Although no formal drug-drug interaction studies have been performed for other AEDs, phenytoin andlamotrigine are addressed based on in vitro data.
Based on in vitro data, gilteritinib is primarily metabolised via CYP3A4.
Хората също превеждат
Lurasidone is not expected to have a clinically relevant inhibitory potential on transporters OATP1B1, OATP1B3, OCT2, OAT1, OAT3, MATE1,MATE2K or BSEP based on in vitro data.
Based on in vitro data, ceritinib is a substrate of the efflux transporter P-glycoprotein(P-gp).
Based on in vitro data, ceritinib also inhibits CYP2A6 and CYP2E1 at clinically relevant concentrations.
Conflicting reports in the literature, based on in vitro findings from human tumour samples, suggest erythropoietins may play a role as tumour proliferators.
Based on in vitro results, ivacaftor and its M1 metabolite have the potential to inhibit CYP3A and P-gp.
Conflicting reports in the literature, based on in vitro findings from human tumour samples, suggest erythropoietins may play a role as tumour proliferators.
Based on in vitro data, CYP2D6, and to a lesser extent CYP1A2 and CYP3A4, were able to metabolize rucaparib.
Furthermore, based on in vitro studies, guanfacine may be an inhibitor of OCT1 at maximal portal vein concentrations.
Based on in vitro data, at clinically relevant concentrations avanafil could be an inhibitor of BCRP.
These reports are based on in vitro findings from human tumour samples, but are of uncertain significance in the clinical situation.
Based on in vitro data brexpiprazole showed little to no inhibition of other CYP450 isozymes.
Based on in vitro data pasireotide appears to be a substrate of efflux transporter P-gp(P-glycoprotein).
Based on in vitro studies it is not expected that doripenem will inhibit or induce the activities of CYP450.
Based on in vitro data, sonidegib is not a substrate of P-gp, BCRP or multi-resistance protein 2(MRP2).
Based on in vitro data, ceritinib is predicted to inhibit intestinal P-gp and BCRP at clinically relevant concentrations.
Based on in vitro studies the activity of dalbavancin is not affected by other classes of vancomycin resistance genes.
Based on in vitro data, ceritinib competitively inhibits the metabolism of a CYP3A substrate, midazolam, and a CYP2C9 substrate, diclofenac.
Based on in vitro data, repaglinide appears to be a substrate for active hepatic uptake(organic anion transporting protein OATP1B1).
Based on in vitro data, betaine might interact with amino acids mixtures and medicinal products containing vigabatrin and GABA analogues.
Based on in vitro studies, empagliflozin is considered unlikely to cause interactions with active substances that are P-gp substrates.
Based on in vitro studies, empagliflozin is considered unlikely to cause interactions with medicinal products that are P-gp substrates.
Based on in vitro studies, the degree of plasma protein binding has been reported to range from 88 to 98%.
Based on in vitro bazedoxifene plasma protein binding characteristics, drug interactions with warfarin, digoxin and diazepam are unlikely.
Based on in vitro studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalysed by CYP3A4.