Примери за използване на Chromosomal aberration на Английски и техните преводи на Български
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Hereditary chromosomal aberration.
The M27 metabolite was negative for genotoxicity in the bacterial mutagenicity and chromosomal aberration assays.
Carfilzomib was clastogenic in the in vitro chromosomal aberration test in peripheral blood lymphocytes.
Genotoxicity(Chromosomal aberration and mouse lymphoma mutation assay) studies with aztreonam were negative.
This error is often caused by a chromosomal aberration.
Talazoparib was clastogenic in an in vitro chromosomal aberration assay in human peripheral blood lymphocytes and in an in vivo bone marrow micronucleus assay in rats but not mutagenic in Ames assay(see section 5.3), and may cause foetal harm when administered to a pregnant woman.
Guanfacine was not genotoxic in a variety of test models, including the Ames test andan in vitro chromosomal aberration test.
A thickened fold of the neck can indicate a chromosomal aberration, of which Down's syndrome is the most common.
Mutagenicity No evidence of mutagenicity or genotoxicity was observed in in vitro microbial mutagenesis(Ames) tests, in vitro alkaline elution assays for DNA breakage andin vitro and in vivo chromosomal aberration studies.
In vivo mouse micronucleus assay, the chromosomal aberration test in human lymphocytes, and the CHO cell mutation test.
Dimethyl fumarate and mono-methylfumarate were negative in a battery of in vitro assays(Ames, chromosomal aberration in mammalian cells).
Lusutrombopag was not genotoxic when tested in a bacterial reverse mutation test, a chromosomal aberration test with cultured Chinese hamster lung cells, or an in vivo micronucleus test with mouse bone marrow cells.
No evidence of mutagenicity or genotoxicity was observed in in vitro microbial mutagenesis(Ames) tests, in vitro alkaline elution assays for DNA breakage andin vitro and in vivo chromosomal aberration studies conducted with raltegravir.
Non-liposomal irinotecan andSN-38 were genotoxic in vitro in the chromosomal aberration test on CHO-cells as well as in the in vivo micronucleus test in mice.
Ritonavir was not found to be mutagenic or clastogenic in a battery of in vitro and in vivo assays including the Ames bacterial reverse mutation assay using S. typhimurium and E. coli, the mouse lymphoma assay,the mouse micronucleus test and chromosomal aberration assays in human lymphocytes.
Trifluridine was shown to be genotoxic in a reverse mutation test in bacteria, a chromosomal aberration test in mammal-cultured cells, and a micronucleus test in mice.
In a chromosomal aberration in vitro study with cultured human peripheral lymphocyte cells, florbetapir did not increase the percent of cells with structural aberrations with 3 hour exposure with or without activation; however, 22 hour exposure produced an increase in structural aberrations at all tested concentrations.
Rivastigmine was not mutagenic in a standard battery of in vitro andin vivo tests, except in a chromosomal aberration test in human peripheral lymphocytes at a dose 10.
Ceftaroline fosamil and ceftaroline were clastogenic in an in vitro chromosomal aberration assay, however there was no evidence of mutagenic activity in an Ames test, mouse lymphoma and unscheduled DNA synthesis assay.
Ferric citrate was neither mutagenic in the bacterial reverse mutation assay(Ames test)nor clastogenic in the chromosomal aberration test in Chinese hamster fibroblasts.
It was not clastogenic in an in vitro test in human lymphocytes(no induction of structural chromosomal aberration but it increased number of polyploid cells) and induced an increase of micronuclei in the in vivo test in rats.
Darunavir was not mutagenic or genotoxic in a battery of in vitro andin vivo assays including bacterial reverse mutation(Ames), chromosomal aberration in human lymphocytes and in vivo micronucleus test in mice.
Rivastigmine was not mutagenic in a standard battery of in vitro andin vivo tests, except in a chromosomal aberration test in human peripheral lymphocytes at a dose 104 times the maximum clinical exposure.
Enoxaparin sodium has shown no mutagenic activity based on in vitro tests, including the Ames test,mouse lymphoma cell forward mutation test, and no clastogenic activity based on an in vitro human lymphocyte chromosomal aberration test, and the in vivo rat bone marrow chromosomal aberration test.
Rivastigmine was not mutagenic in a standard batteryof in vitro and in vivo tests, except in a chromosomal aberration test in human peripheral lymphocytes at a dose 104 times the maximum clinical exposure.
Alitretinoin was studied for genotoxic potentialusing the Ames test, the in vivo mouse micronucleus assay, the chromosomal aberration test in human lymphocytes, and the CHO cell mutation test.
Talazoparib was not mutagenic in a bacterial reverse mutation(Ames) test. Talazoparib was clastogenic in an in vitro chromosomal aberration assay in human peripheral blood lymphocytes and in an in vivo micronucleus assay in rats at exposures similar to clinically relevant doses.
However, the mutagenic potential has been evaluated, and alitretinoin has tested negativein the Ames test, the in vivo mouse micronucleus assay, the chromosomal aberration test in human lymphocytes, and the CHO cell mutation test.
Drotrecogin alfa(activated) was not mutagenic in an in vivo micronucleusstudy in mice or in an in vitro chromosomal aberration study in human peripheral blood lymphocytes with or without rat liver metabolic activation.
Darunavir was not mutagenic or genotoxic in a battery of in vitro andin vivo assays including bacterial reverse mutation(Ames), chromosomal aberration in human lymphocytes and in vivo micronucleus test in mice.