Примери за използване на Concentration curve на Английски и техните преводи на Български
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Area under the concentration curve(AUC).
There is a linear relationship between dose and both Cmax andAUC(area under the time/concentration curve).
AUC: Area under the plasma concentration curve from 0 to infinity.
In patients administered 15-90 mg/m2,there is a linear relationship between dose and the area under the concentration curve(AUC).
Area under the plasma concentration curve(AUC) of ertapenem in adults increases nearly doseproportionally over the 0.5 to 2 g dose range.
Various mechanisms of action andhalf-lives can manipulate the concentration curve, achieving optimal anabolic response.
The area under the plasma concentration curve(AUC) for montelukast was decreased approximately 40% in subjects with co-administration of phenobarbital.
Different mechanisms of action andhalf-lives allow us to manipulate the concentration curve for optimal anabolic response.
Pharmacokinetic studies in humans showed that the plasma concentration curve of cladribine fits a 2or 3-compartment model with- and β-half-lives of on average 35 minutes and 6.7 hours, respectively.
Limited data suggest that probenecid increasesthe mean half-life and area under the plasma concentration curve of zidovudine by decreasing glucuronidation.
Pharmacokinetics is nonlinear with the area under the plasma concentration curve(AUC) versus time curve increasing 3.8-fold as dose is doubled from 4.5 g to 9 g. The pharmacokinetics is not altered with repeat dosing.
Increasing doses of raloxifene result in slightly less than proportional increase in the area under the plasma time concentration curve(AUC).
In a single-dose study, serum digoxin area under plasma concentration curve(AUC) decreased 12% due to concomitant administration of Topamax.
Increasing doses of raloxifene result in slightly less than proportional increase in the area under the plasma time concentration curve(AUC).
Following repeat once-daily dosing, apalutamide exposure(Cmax and area under the concentration curve[AUC]) increased in a dose-proportional manner across the dose range of 30 to 480 mg.
AUC= area under the plasma concentration curve(extrapolated to infinity for ONIVYDE pegylated liposomal and AUC24h for non-liposomal irinotecan) Cmax= maximum plasma concentration t1/2 effective= effective half-lives.
The pharmacokinetic part of the above mentioned study showed that the blood concentration curve of carisoprodol increases and falls rapidly.
In cynomolgus monkeys, no effects on embryo-foetal or postnatal(up to 6 months of age)development were observed when brodalumab was dosed subcutaneously throughout pregnancy at exposure levels up to 27-fold higher than those achieved in human patients receiving Kyntheum 210 mg every 2 weeks based on the area under the concentration curve(AUC).
Limited data suggest that probenecid increases the mean half-life and area under the plasma concentration curve of zidovudine by decreasing glucuronidation.
Pharmacokinetics are nonlinear with the area under the plasma concentration curve(AUC) versus time curve increasing 3.8-fold as dose is doubled from 4.5g to 9g.
The ratios of geometric least-square means of ReFacto AF-to-ReFacto were 100.6%, 99.5% and 98.1% for K-value, AUCt andAUC∞(area under the plasma concentration curve from time zero to infinity), respectively.
Vancomycin displays concentration-independent activity with the area under the concentration curve(AUC) divided by the minimum inhibitory concentration(MIC) of the target organism as the primary predictive parameter for efficacy.
Primary variables were AUCδ0-36 and Cδmax of estradiol,i.e. the extent of exposure was estimated as area under the baseline adjusted estradiol concentration curve and the baseline-adjusted maximal plasma concentration of estradiol.
The short half-life of 13 minutes accounts for approximately 80% of the area under the plasma concentration curve and governs the initial rapid accrual of plasma drotrecogin alfa(activated) concentrations towards the steady-state.
Median steady-state maximum concentration(Cmax) is 282.0 ng/mL(CV%= 50.8), and area under the plasma concentration curve during 24-hour dosing interval(AUC0-24) is 6180 ng·h/mL(CV%= 46.4) after once-daily dosing of 120 mg gilteritinib.
A biexponential curve is required to describe the concentration time curve of etanercept.
AUCss= Area under the plasma concentration time curve at steady-state Cmax= Maximum concentration. .
Area under the concentration time curve from 0h data point up to last measurable.
Voriconazole increased tacrolimus(0.1 mg/ kg single dose) Cmax and AUCt(area under the plasma concentration time curve to the last quantifiable measurement) by 117% and 221%, respectively.
The planned sampling schedule should provide an adequate estimation of the Cmax andshould cover the plasma concentration time curve sufficiently to provide a reliable estimate of the extent of absorption.