Примери за използване на Further dose reduction на Английски и техните преводи на Български
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Requirement for further dose reduction.
Further dose reduction may be necessary.
When ritonavir is co-administered further dose reduction may be necessary(see section 4.5).
Further dose reduction may be necessary(see section 4.5).
Consider dose escalation to 1.0 mg/m2 or further dose reduction to 0.5 mg/m2.
Consider further dose reduction in these patients.
In patients with creatinine clearance less than 15 mL/min and on dialysis further dose reduction should be considered.
Further dose reduction of rifabutin has not been studied.
Topotecan was discontinued if the dose had been reduced to 1.0 mg/m and a further dose reduction was required to manage adverse effects.
If further dose reduction below 75 mg/day is required, discontinue the treatment.
If patients continue to experience any of these reactions at 20 mg/m2, further dose reduction to 15 mg/m2 or discontinuation of JEVTANA may be considered.
Further dose reduction may be required to manage adverse reactions(see sections 4.2 and 4.4).
Topotecan was discontinued if the dose had been reduced to 1.0 mg/m 2/day and a further dose reduction was required to manage adverse effects.
In the event that further dose reductions are necessary, treatment discontinuation should be considered.
The peculiarity of asthma treatment is that you need to use drugs in the lowest effective dose and to seek for further dose reduction.
Patients who require further dose reduction should discontinue treatment.
The panel's objective is to generate proposals for how manufacturers may continue to develop their technology andto help users better adapt their procedures in order to bring about further dose reduction in CT.
Mg*/day* If further dose reduction below 200 mg/day is required, the treatment should be permanently discontinued.
In such cases there should be close attention to adverse drug reaction, and further dose reduction may be considered if possible drug-related adverse events are observed.
Further dose reductions should be considered on an individual patient basis as limited data are available for doses below 10 mg.
Consider dose escalation to 1.0 mg/m2 or further dose reduction to 0.5 mg/m2 in subsequent cycles based on patient tolerability.
If further dose reduction is needed, a second dose reduction from two hard capsules daily(200 mg) to one capsule daily(100 mg) may be implemented.
If this is unavoidable, patients should be closely monitored and further dose reduction or discontinuation may be considered as clinically indicated(see section 4.5).
If a further dose reduction is required, then reduction to 100 mg twice daily(equivalent to a total daily dose of 200 mg) is recommended.
In patients with creatinine clearance less than 15 mL/min and on dialysis further dose reduction is likely to be required as etoposide clearance is further reduced in these patients(see section 4.4).
If further dose reduction is necessary, then the dose should be modified to 250 mg taken once daily based on individual safety and tolerability.
Consider dose escalation to 1.0 mg/m2 or further dose reduction to 0.5 mg/m2 in subsequent cycles based on patient tolerability.
Patients with moderate or severe hepatic impairment should be started on VELCADE at a reduced dose of 0.7 mg/m2 per injection during the first treatment cycle,and a subsequent dose escalation to 1.0 mg/m or further dose reduction to 0.5 mg/m 2 may be considered based on patient tolerability(see Table 6 and sections 4.4 and 5.2).
CTC grade 3 or 4 toxicity recurrence- a further dose reduction may be considered once the adverse event has resolved to CTC grade< 1.
If a further dose reduction is required, then reduction to 200 mg(two 100 mg tablets) twice daily(equivalent to a total daily dose of 400 mg) is recommended.