Примери за използване на Isozymes на Английски и техните преводи на Български
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Cytochrome P450 isozymes.
Other isozymes involved are CYP1A2 and CYP2C9.
Brinzolamide is not an inhibitor of cytochrome P-450 isozymes.
There is also an increased frequency of isozymes of 7, 15, 19 and X in seminoma.
Methylnaltrexone is minimally metabolised by CYP isozymes.
Fluconazole is a selective inhibitor of the isozymes CYP2C9 and CYP3A4(see section 4.5).
In-vitro studies showed that delamanid did not inhibit CYP450 isozymes.
The effect of strong inhibitors of these isozymes on axitinib pharmacokinetics has not been studied.
Naldemedine did not cause significant induction of CYP1A2, CYP2B6 or CYP3A4 isozymes.
Pepsins(of which there are several isozymes) are the principal proteases in gastric secretions of adult mammals.
Based on in vitro data brexpiprazole showed little to no inhibition of other CYP450 isozymes.
For potential interactions with isozymes 1A2, 2C9 and 3A4, see interactions with coumarin-derivative anticoagulation.
Interferon alfa has shown to influence the activity of cytochrome P450(CYP) isozymes CYP1A2 and CYP2D6.
The cytochrome P-450 isozymes responsible for metabolism of brinzolamide include CYP3A4(main), CYP2A6, CYP2C8 and CYP2C9.
In vitro studies indicate that bortezomib is a weak inhibitor of the cytochrome P450(CYP) isozymes 1A2, 2C9, 2C19, 2D6 and 3A4.
The in vitro studies suggest that CYP3A4 andCYP2B6 are the major isozymes responsible for efavirenz metabolism and that it inhibits CYP isozymes 2C9, 2C19, and 3A4.
Methylnaltrexone bromide does not affect the pharmacokinetics of medicinal products metabolised by cytochrome P450(CYP) isozymes.
In vitro data showed that sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4 and CYP1A2.
Caution should be exercised due to the risk of increased axitinib plasma concentrations in patients taking strong inhibitors of these isozymes.
When Atripla is coadministered with an anticonvulsant that is a substrate of CYP isozymes, periodic monitoring of anticonvulsant levels should be conducted.
In vitro studies indicate that irinotecan, SN-38 and another metabolite aminopentane carboxylic acid(APC) do not inhibit cytochrome P-450 isozymes.
The in vitro studies suggest that CYP3A4 and CYP2B6 are the major isozymes responsible for efavirenz metabolism and that it inhibited P450 isozymes 2C9, 2C19, and 3A4.
Linagliptin is a weak competitive and a weak to moderate mechanism-based inhibitor of CYP isozyme CYP3A4, butdoes not inhibit other CYP isozymes.
In vitro studies with human liver microsomes andhuman cDNA-expressed cytochrome P450 isozymes indicate that bortezomib is primarily oxidatively metabolised via cytochrome P450 enzymes, 3A4, 2C19, and 1A2.
Paliperidone is not expected to cause clinically important pharmacokinetic interactions with medicinal products that are metabolised by cytochrome P-450 isozymes.
In vitro studies with human liver microsomes andhuman cDNA-expressed cytochrome P450 isozymes indicate that bortezomib is primarily oxidatively metabolised via cytochrome P450 enzymes, 3A4, 2C19, and 1A2.
There is a potential for reduction or increase in the plasma concentrations of phenytoin, phenobarbital andother anticonvulsants that are substrates of CYP isozymes with efavirenz.
In vitro studies using human cDNA-expressed cytochrome P450 isozymes indicate that no specific CYP isozyme predominantly contributes to ixazomib metabolism and non-CYP proteins contribute to overall metabolism.
In in vitro studies, lixisenatide did not affect the activity of cytochrome P450 isozymes or human transporters tested.
No inhibitory effect was observed in healthy subjects for the cytochrome P450 isozymes CYP2C19(omeprazole, diazepam), CYP3A4/5(ethinyl estradiol, midazolam), CYP2B6(bupropion), CYP2C9(tolbutamide, S-warfarin), CYP1A2(caffeine) or CYP2D6(dextromethorphan).