Примери за използване на Juvenile rats на Английски и техните преводи на Български
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However, juvenile rats are more sensitive.
Studies have been conducted in juvenile rats and dogs.
Juvenile rats seemed to be more sensitive to lymphocytic inflammation of thyroid.
In addition, the toxicity profile in juvenile rats was comparable to that observed in adult rats. .
Juvenile rats are more sensitive than adult rats to ruxolitinib toxicity.
A single dose study was conducted in juvenile rats aged 14, 21, 24, 28, 31 or 36 days post-partum.
In juvenile rats the types of toxicity do not differ qualitatively from those observed in adult rats. .
Pharmacologically mediated effects were observed in juvenile rats treated with ertugliflozin(see section 5.3).
Evaluations in juvenile rats(comparable to a< 2 year old pediatric population) have not been performed.
The general toxicity profile of duloxetine in juvenile rats was similar to that in adult rats. .
Treatment of juvenile rats for 30 day beginning at 21 days of age delayed the puberty onset.
Other than bone development,the effects of ruxolitinib in juvenile rats were similar to those in adult rats. .
In juvenile rats and dogs, the types of toxicity do not differ qualitatively from those observed in adult animals.
No alogliptin-related effects were observed in juvenile rats following repeat-dose administration for 4 and 8 weeks.
In juvenile rats receiving darunavir up to days 23-26, increased mortality was observed with convulsions in some animals.
Decitabine administration to neonatal/juvenile rats showed a comparable general toxicity profile as in older rats. .
In juvenile rats, a reduced body weight was observed at systemic exposure levels similar to the expected clinical exposure.
Dulaglutide dosing of male and female juvenile rats did not produce memory deficits at 91-fold the human exposure.
In juvenile rats treated with sacubitril(postnatal days 7 to 70), there was a reduction in age-related bone mass development and bone elongation.
Reduced acoustic startle response was observed in juvenile rats 1-2 weeks after exposure at> 2 times the human therapeutic exposure.
In juvenile rats receiving darunavir up to days 23-26(equivalent to less than 2 years of age in humans), increased mortality was observed with convulsions in some animals.
Results from a mechanistic study showed that the MDR1(P-gp)gene expression in juvenile rats was significantly lower when compared to adult rats. .
Dalbavancin toxicity profile in juvenile rats was consistent with that previously observed in adult rats at the same dose(mg/kg/day) levels.
It is likely that the increased susceptibility to opportunistic infections observed in juvenile rats is associated with the exposure to abatacept before development of memory responses.
A study in juvenile rats administered canagliflozin from day 1 through day 90 postnatal did not show increased sensitivity compared to effects observed in adults rats. .
Following intravenous injection of methylnaltrexone bromide, juvenile rats were found to be more sensitive than adult rats to methylnaltrexone-related toxicity.
Studies in juvenile rats reveal transient effects on neurobehaviour, as well as significantly decreased body weight and food consumption; hepatic enzyme induction; and hepatocellular vacuolation at 45 mg/kg/day.
The main effects reported after repeated administration of propranolol in adult and juvenile rats were a transient decrease in body weight and body weight gain associated with a transient decrease in organ weight.
In juvenile rats, the changes consisted of thickening of trabecular bone and of hyperostosis and remodeling of metaphyseal and diaphyseal bone, whereas in adolescent rats an overall increase of bone mass was observed.
At this higher dose level, juvenile rats showed a decrease in growth, learning, and developmental parameters.